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Cat. No.: HY-155699

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J27644

J27644 is a potent HDAC inhibitor. J27644 mitigates TGF-β-induced pulmonary fibrosis.

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CAS No.: 3033032-03-7
Formule: C₁₆H₁₂ClN₃O₄
Masse moléculaire:345.74

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

J27644 Chemical Structure

CAS No.: 3033032-03-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

J27644 is a potent HDAC inhibitor. J27644 mitigates TGF-β-induced pulmonary fibrosis^[1].

Voir tous les produits spécifiques à Isoform HDAC :

Cellular Effect

Cell Line	Type	Value	Description	References
Fibroblast	IC₅₀	8.82 μM Compound: 15; J27644	Antiproliferative activity against human Pulmonary fibroblast cells assessed as reduction in cell viability incubated for 3 days by CCK-8 assay Antiproliferative activity against human Pulmonary fibroblast cells assessed as reduction in cell viability incubated for 3 days by CCK-8 assay	[PMID: 37463500]
NIH3T3	IC₅₀	18.55 μM Compound: 15; J27644	Antiproliferative activity against mouse NIH3T3 cells assessed as reduction in cell viability incubated for 3 days by CCK-8 assay Antiproliferative activity against mouse NIH3T3 cells assessed as reduction in cell viability incubated for 3 days by CCK-8 assay	[PMID: 37463500]

Chemical Information

CAS No. 3033032-03-7
Masse moléculaire 345.74
Formule C₁₆H₁₂ClN₃O₄
SMILES

O=C(NC1=O)C2=CC=CC(Cl)=C2N1CC3=CC=C(C=C3)C(NO)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Yu WC, et, al. Discovery of HDAC6, HDAC8, and 6/8 Inhibitors and Development of Cell-Based Drug Screening Models for the Treatment of TGF-β-Induced Idiopathic Pulmonary Fibrosis. J Med Chem. 2023 Aug 10;66(15):10528-10557. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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J27644

Voir tous les produits spécifiques à Isoform HDAC

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

J27644 Related Classifications

HY-155699 Related Classifications