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Cat. No.: HY-164995

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L1BC8

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L1BC8 (compound 13a) is a BRD4 PROTAC degrader with anticancer effects. L1BC8 is also a drug-linker conjugate for ADC that can be used for the synthesis of ADCs. The resulting BRD4-degrader antibody conjugates exhibit potent and antigen-dependent BRD4 degradation and antiproliferation activities in cell-based experiments.
(Pink: BRD4 ligand (HY-129939); Blue: VHL ligand (HY-125845); Black: linker (HY-171663)).

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Pureté: 99.20%
CAS No.: 2417370-68-2
Formule: C₈₆H₉₈F₂N₁₆O₁₈S₂
Masse moléculaire:1745.92

Stockage:

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

L1BC8 Chemical Structure

CAS No.: 2417370-68-2

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Activité biologique

Description

L1BC8 (compound 13a) is a BRD4 PROTAC degrader with anticancer effects. L1BC8 is also a drug-linker conjugate for ADC that can be used for the synthesis of ADCs. The resulting BRD4-degrader antibody conjugates exhibit potent and antigen-dependent BRD4 degradation and antiproliferation activities in cell-based experiments^[1]. (Pink: BRD4 ligand (HY-129939); Blue: VHL ligand (HY-125845); Black: linker (HY-171663)).

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Chemical Information

CAS No. 2417370-68-2
Appearance Solid
Masse moléculaire 1745.92
Formule C₈₆H₉₈F₂N₁₆O₁₈S₂
Color White to off-white
SMILES

O=C(OCC1=CC=C(NC([C@@H](NC(C2(CCC2)C(NCCCCCN3C(C=CC3=O)=O)=O)=O)CCCNC(N)=O)=O)C=C1)NC4=CC(CCOCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)=CC(OCCNC(C8=C(CS(=O)(C)=O)C=C(C(N(C9=NC=C(F)C=C9F)C%10)=C8)C%11=CN(C)C(C%12=C%11C%10=CN%12)=O)=O)=C4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Dragovich PS, et al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
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L1BC8

Voir tous les produits spécifiques à Isoform PROTACs

Voir tous les produits spécifiques à Isoform Epigenetic Reader Domain

Voir tous les produits spécifiques à Isoform Drug-Linker Conjugates for ADC

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

L1BC8 Related Classifications

HY-164995 Related Classifications