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Methicillin

7 Cited Publications

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Based on 7 publication(s) in Google Scholar

Methicillin is a narrow-spectrum β-lactam antibiotic, acts by inhibiting penicillin-binding proteins (PBPs). Methicillin is active against Staphylococcus aureus and Staphylococcus epidermidis that are resistant to other penicillins.Methicillin can be used for the research of skin infections, osteomyelitis, and endocarditis.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 61-32-5
Formule: C₁₇H₂₀N₂O₆S
Masse moléculaire:380.42

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Methicillin Chemical Structure

CAS No.: 61-32-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Essai clinique
Chemical Information
Publications (7)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

β-lactam

Voir tous les produits spécifiques à Isoform Antibiotic :

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Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	116 μM Compound: Methicillin	Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins	[PMID: 23344796]
Vero	CC₅₀	>200 μM Compound: Methicillin	Cytotoxicity against African green monkey Vero cells Cytotoxicity against African green monkey Vero cells	[PMID: 27036520]

In Vitro

Methicillin (20 μg/mL, 24 h) results in a rapid decrease in CFU of S. aureus^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Methicillin (Intramuscular administration, 40 mg/kg every 6 h, 5 days), in S. aureus.-infected rabbits^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 61-32-5
Masse moléculaire 380.42
Formule C₁₇H₂₀N₂O₆S
SMILES

OC([C@@H]1N(C2=O)[C@@](SC(C)1C)([H])[C@@H]2NC(C(C(OC)=CC=C3)=C3OC)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (7)

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Journal Impact Factor

Chem Eng J

2026 Jan 19;529:173215.
Nano Today

2024 Dec.
Nano Today

2022, 47: 101683.
Sci Rep

Anandamide alters the membrane properties, halts the cell division and prevents drug efflux in multidrug resistant Staphylococcus aureus. [Abstract]

2021 Apr 22;11(1):8690. PMID: 33888802

Methicillin purchased from MedChemExpress. Usage Cited in: Sci Rep. 2021 Apr 22;11(1):8690. [Abstract]

Disc diffusion assay using circled Whatman paper containing 50 μg of the indicated antibiotics. M Methicillin sodium salt, G Gentamicin, E Erythromycin.

Methicillin purchased from MedChemExpress. Usage Cited in: Sci Rep. 2021 Apr 22;11(1):8690. [Abstract]

The susceptibility of planktonic growing bacteria to increasing doses of Methicillin sodium salt (0-100 μg/mL). The OD_{595 nm} of the samples was measured after a 24 h incubation.

Methicillin purchased from MedChemExpress. Usage Cited in: Sci Rep. 2021 Apr 22;11(1):8690. [Abstract]

The survival of planktonic growing MDRSA CI-M in the absence or presence of 50 μg/ml Methicillin (Methicillin sodium salt) and increasing concentrations of AEA.

Methicillin purchased from MedChemExpress. Usage Cited in: Sci Rep. 2021 Apr 22;11(1):8690. [Abstract]

A kinetic study of the planktonic growth of MDRSA CI-M in the absence or presence of 50 μg/ml AEA and/or 50 μg/ml Methicillin sodium salt for 20 h.

Methicillin purchased from MedChemExpress. Usage Cited in: Sci Rep. 2021 Apr 22;11(1):8690. [Abstract]

Biofilm formation after a 24 h incubation of MDRSA CI-M in the absence or presence of 25 or 50 μg/ml Methicillin sodium salt and increasing concentrations of AEA as measured by crystal violet staining.
Biomed Res Int

In Vitro Activity of β-Lactams in Combination with β-Lactamase Inhibitors against Mycobacterium tuberculosis Clinical Isolates. [Abstract]

2018 Jul 2:2018:3579832. PMID: 30065936
bioRxiv

2025 Oct 27.
Research Square Print

October 6th, 2022.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Sharon S. Castle. Methicillin. xPharm: The Comprehensive Pharmacology Reference 2007, Pages 1-4.

[2]. Jaime Carrizosa, et al. Treatment of Experimental Staphylococcus aureus Endocarditis: Comparison of Cephalothin, Cefazolin, and Methicillin. Antimicrob Agents Chemother. 1978 Jan; 13(1): 74–77.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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7 Cited Publications

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Methicillin purchased from MedChemExpress. Usage Cited in: Sci Rep. 2021 Apr 22;11(1):8690. [Abstract]

Customer Validation
Disc diffusion assay using circled Whatman paper containing 50 μg of the indicated antibiotics. M Methicillin sodium salt, G Gentamicin, E Erythromycin.

1/16

Methicillin purchased from MedChemExpress. Usage Cited in: Sci Rep. 2021 Apr 22;11(1):8690. [Abstract]

Customer Validation
The susceptibility of planktonic growing bacteria to increasing doses of Methicillin sodium salt (0-100 μg/mL). The OD_{595 nm} of the samples was measured after a 24 h incubation.

1/16

Methicillin purchased from MedChemExpress. Usage Cited in: Sci Rep. 2021 Apr 22;11(1):8690. [Abstract]

Customer Validation
The survival of planktonic growing MDRSA CI-M in the absence or presence of 50 μg/ml Methicillin (Methicillin sodium salt) and increasing concentrations of AEA.

1/16

Methicillin purchased from MedChemExpress. Usage Cited in: Sci Rep. 2021 Apr 22;11(1):8690. [Abstract]

Customer Validation
A kinetic study of the planktonic growth of MDRSA CI-M in the absence or presence of 50 μg/ml AEA and/or 50 μg/ml Methicillin sodium salt for 20 h.

1/16

Methicillin purchased from MedChemExpress. Usage Cited in: Sci Rep. 2021 Apr 22;11(1):8690. [Abstract]

Customer Validation
Biofilm formation after a 24 h incubation of MDRSA CI-M in the absence or presence of 25 or 50 μg/ml Methicillin sodium salt and increasing concentrations of AEA as measured by crystal violet staining.

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Methicillin

Publications Citing Use of MedChemExpress (MCE) Methicillin

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