country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-170674A

Copy Link Print Information

ND-L11B TFA

ND-L11B TFA is an NSD2 degrader with a K_d value of 8.77 μM, degrading the NSD2-long and RE-IIBP isoforms in multiple myeloma cells with DC₅₀ values of 1.48 μM and 0.8 μM, respectively. ND-L11B TFA reduces H3K36me2 levels and inhibits the proliferation of multiple myeloma cells. ND-L11B TFA serves as a starting point for the further development of NSD2-targeted compounds and is also a chemical knockdown tool for elucidating the multiple functions of NSD2 isoforms. ND-L11B TFA can be used for research on multiple myeloma.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₃₉H₅₂F₆N₁₀O₄
Masse moléculaire:838.89

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

ND-L11B TFA Chemical Structure

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

^[1]

NSD2

8.77 μM (Kd)

Voir tous les produits spécifiques à Isoform Histone Methyltransferase :

In Vitro

Anti-cancer

ND-L11B TFA (0.09-5.0 μM; 6-48 h) simultaneously degrades both NSD2-long and RE-IIBP isoforms in KMS11 multiple myeloma cells, with DC₅₀ values of 1.48 μM and 0.80 μM, respectively, and induces time-dependent NSD2 degradation from 6 to 48 h^[1].
ND-L11B TFA (0.63-2.50 μM for KMS11 cells; 2.0-8.0 μM for 22RV1 cells) downregulates H₃K₃₆ methylation levels in KMS11 multiple myeloma cells and 22RV1 prostate cancer cells^[1].
ND-L11B TFA (12-day exposure of KMS11 cells; 8-day exposure of 293T cells) potently inhibits the proliferation of KMS11 multiple myeloma cells with an IC₅₀ of 0.90 μM, while showing very low cytotoxicity against non-malignant human embryonic kidney 293T cells (IC₅₀ > 100 μM)^[1].
ND-L11B TFA (1.25-2.50 μM; 2 days) downregulates the expression of NSD2-regulated cancer-related genes in KMS11 multiple myeloma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

KMS11 multiple myeloma cells
Concentration:

0.09, 0.13, 0.20, 0.29, 0.44, 0.66, 0.99, 1.48, 2.22, 3.33, 5.0 μM; 5 μM (time-dependent assay)
Incubation Time:

6, 12, 24, 36, 48 h (5 μM concentration)
Result:

Induced simultaneous concentration-dependent degradation of NSD2-long and RE-IIBP isoforms, with DC₅₀ values of 1.48 μM (NSD2-long) and 0.80 μM (RE-IIBP), and a maximum degradation (D_max) of approximately 80%.
Induced time-dependent degradation of NSD2 protein over 6 to 48 hours.

Real Time qPCR^[1]

Cell Line:

KMS11 multiple myeloma cells
Concentration:

1.25, 2.50 μM
Incubation Time:

2 days
Result:

Downregulated the expression of NSD2-regulated oncogenes and cancer-related genes including JAM2, MET, PAK1, RRAS2, BACE2, CA2, IGF2BP2, and CR2.

Related Protocols :

Chemical Information

Masse moléculaire 838.89
Formule C₃₉H₅₂F₆N₁₀O₄
SMILES

O=C(NCCCCCCCCCCCN)COC1=CC(C2=NC=C(N3C[C@](CC(F)F)(N)CCC3)C(CN4C=NC5=C(N)N=CN=C45)=C2)=CC=C1F.O=C(O)C(F)(F)F
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (280 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Hu L, et al. Discovery of SET domain-binding primary alkylamine-tethered degraders for the simultaneous degradation of NSD2-long and RE-IIBP isoforms. European journal of medicinal chemistry. 2025 Feb 05;283:117179. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

ND-L11B TFA

Voir tous les produits spécifiques à Isoform Histone Methyltransferase

Activité biologique

Description

IC50 & Target

In Vitro

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

ND-L11B TFA Related Classifications

HY-170674A Related Classifications

Bioz

Keywords

Your Recently Viewed Products

IC₅₀ & Target