Rabelomycin
Rabelomycin is an angucycline antibiotic and inducible nitric oxide synthase (iNOS) inhibitor with an IC50 of 63.9 μM. Rabelomycin can be used in research on bacterial infections, Alzheimer's disease, and Huntington's disease.
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- CAS No.: 28399-50-0
- Formule: C19H14O6
- Masse moléculaire:338.31
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[1]|
iNOS 63.9 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
4.28 μM
Compound: 8
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Cytotoxicity against human MCF7 cells by SRB assay
Cytotoxicity against human MCF7 cells by SRB assay
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[PMID: 23136829] |
| NCI-H460 | IC50 |
9.91 μM
Compound: 8
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Cytotoxicity against human NCI-H460 cells by SRB assay
Cytotoxicity against human NCI-H460 cells by SRB assay
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[PMID: 23136829] |
| SF-268 | IC50 |
5.54 μM
Compound: 8
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Cytotoxicity against human SF268 cells by SRB assay
Cytotoxicity against human SF268 cells by SRB assay
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[PMID: 23136829] |
In Vitro
Rabelomycin (100-10 mM; 30 minutes) dose-dependently inhibits partially purified iNOS enzyme from RAW 264.7 macrophage cell lysate with an IC50 of 63.9 μM[1].
Rabelomycin inhibits the growth of Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213, Bacillus thuringiensis SCSIO BT01 and Bacillus subtilis SCSIO BS01, with MICs of 16 μg/mL, 1 μg/mL, 8 μg/mL and 16 μg/mL, respectively[3].
Rabelomycin inhibits the growth of SF-268, MCF-7, and NCI-H460 cells, with IC50 values of 5.54 μM, 4.28 μM, and 9.91 μM, respectively[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 28399-50-0
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Masse moléculaire 338.31
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Formule C19H14O6
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SMILES
O=C1C2=C(C[C@@](O)(C1)C)C=C(O)C(C(C3=C(O)C=CC=C34)=O)=C2C4=O
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Structure Classification
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Initial Source
Streptomyces sp.
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Alvi KA, et al. Identification of inhibitors of inducible nitric oxide synthase from microbial extracts. J Antibiot (Tokyo). 2000;53(5):496-501. [Content Brief]
[2]. Yang K, et al. Accumulation of the angucycline antibiotic rabelomycin after disruption of an oxygenase gene in the jadomycin B biosynthetic gene cluster of Streptomyces venezuelae. Microbiology (Reading). 1996;142 ( Pt 1):123-132. [Content Brief]
[3]. Zhang W, et al. Fluostatins I-K from the South China Sea-derived micromonospora rosaria SCSIO N160. J Nat Prod. 2012 Nov 26;75(11):1937-43. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Rabelomycin Related Classifications
HY-114798 Related Classifications
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