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Cat. No.: HY-121684

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Ramentaceone

Name: Ramentaceone
Brand: MedChemExpress
SKU: HY-121684
Availability: PreOrder

(Synonyms: 7-Methyljuglon)

Ramentaceone (7-Methyljuglon), a naphthoquinone that can be isolated from Drosera sp., inhibits PI3K activity. Ramentaceone (7-Methyljuglon) reduces the expression of the PI3K protein and inhibits the phosphorylation of the Akt protein in breast cancer cells. Ramentaceone (7-Methyljuglon) induces apoptosis.

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CAS No.: 14787-38-3
Formule: C₁₁H₈O₃
Masse moléculaire:188.18

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Ramentaceone Chemical Structure

CAS No.: 14787-38-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform PI3K :

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	11.9 μM Compound: 1	Cytotoxicity against human DU145 cells assessed as cell survival after 24 hrs by XTT assay Cytotoxicity against human DU145 cells assessed as cell survival after 24 hrs by XTT assay	[PMID: 25059501]
HeLa	IC₅₀	66.6 μM Compound: 1	Cytotoxicity against human HeLa cells assessed as cell survival after 24 hrs by XTT assay Cytotoxicity against human HeLa cells assessed as cell survival after 24 hrs by XTT assay	[PMID: 25059501]
HL-60	IC₅₀	8.75 μM Compound: 1, 7-methyljuglone	Cytotoxicity against human HL60 cells after 24 hrs by MTT assay Cytotoxicity against human HL60 cells after 24 hrs by MTT assay	[PMID: 22250825]
HUVEC	ED₅₀	5.7 μg/mL Compound: 9	Cytotoxicity against human HUVEC Cytotoxicity against human HUVEC	[PMID: 15270571]
KB	ED₅₀	4.1 μg/mL Compound: 9	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 15270571]
LNCaP	ED₅₀	3.7 μg/mL Compound: 9	Cytotoxicity against human LNCAP cells Cytotoxicity against human LNCAP cells	[PMID: 15270571]
Lu1	ED₅₀	13.2 μg/mL Compound: 9	Cytotoxicity against human Lu1 cells Cytotoxicity against human Lu1 cells	[PMID: 15270571]
MCF7	IC₅₀	27.2 μM Compound: 1	Cytotoxicity against human MCF7 cells assessed as cell survival after 24 hrs by XTT assay Cytotoxicity against human MCF7 cells assessed as cell survival after 24 hrs by XTT assay	[PMID: 25059501]
NFF	IC₅₀	7.6 μM Compound: 2	Cytotoxicity against human NFF cells assessed as reduction in cell viability after 48 hrs by resazurin dye based assay Cytotoxicity against human NFF cells assessed as reduction in cell viability after 48 hrs by resazurin dye based assay	[PMID: 33314932]
PBMC	IC₅₀	18.4 μM Compound: 1	Cytotoxicity against human PBMC assessed as cell survival after 24 hrs by XTT assay Cytotoxicity against human PBMC assessed as cell survival after 24 hrs by XTT assay	[PMID: 25059501]
Vero	IC₅₀	15.1 μg/mL Compound: 6	Cytotoxicity against Vero cells after 48 hrs by XTT method Cytotoxicity against Vero cells after 48 hrs by XTT method	[PMID: 17888665]

Chemical Information

CAS No. 14787-38-3
Masse moléculaire 188.18
Formule C₁₁H₈O₃
SMILES

O=C1C=CC(C2=C1C=C(C)C=C2O)=O
Synonyms

7-Methyljuglon
Structure Classification
- Quinones
- Naphthalene Quinones
Initial Source
- Plants
- Droseraceae
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Anna Kawiak, et al. Ramentaceone, a Naphthoquinone Derived from Drosera sp., Induces Apoptosis by Suppressing PI3K/Akt Signaling in Breast Cancer Cells. PLoS One. 2016 Feb 3;11(2):e0147718. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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Chemical Information
Pureté et documentation
Références

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Ramentaceone

Voir tous les produits spécifiques à Isoform PI3K