(S)-Hydroxychloroquine
Based on 2 publication(s) in Google Scholar
(S)-Hydroxychloroquine ((S)-HCQ) is the enantiomer of Hydroxychloroquine. Hydroxychloroquine, a synthetic antimalarial agent, inhibits Toll-like receptor 7/9 (TLR7/9) signaling, and shows efficiently inhibits SARS-CoV-2 infection in vitro.
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- CAS No.: 137433-24-0
- Formule: C18H26ClN3O
- Masse moléculaire:335.87
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Stockage:
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Publications Citing Use of MedChemExpress (MCE) (S)-Hydroxychloroquine
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Activité biologique
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Plasmodium |
TLR7 |
TLR9 |
Chemical Information
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CAS No. 137433-24-0
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Masse moléculaire 335.87
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Formule C18H26ClN3O
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SMILES
CCN(CCO)CCC[C@@H](NC1=CC=NC2=CC(Cl)=CC=C12)C
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Synonyms
(S)-HCQ
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Biochem Pharmacol
Agomelatine alleviates hypoxia-induced pulmonary arterial hypertension by activating mitophagy via the SIRT1/FoxO1/ULK1 signaling pathway. [Abstract]2026 Feb:244:117624. PMID: 41360230 -
J Cell Mol Med
LRP5 regulates cardiomyocyte proliferation and neonatal heart regeneration by the AKT/P21 pathway. [Abstract]2022 May;26(10):2981-2994. PMID: 35429093
Pureté et documentation
Références
[1]. Cardoso CD, et al. Enantioselective analysis of the metabolites of hydroxychloroquine and application to an in vitro metabolic study. J Pharm Biomed Anal. 2005 Apr 1;37(4):703-8. [Content Brief]
[2]. Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6. [Content Brief]
[3]. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40. [Content Brief]
[4]. Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Mar 9. pii: ciaa237. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S)-Hydroxychloroquine Related Classifications
HY-B1370A Related Classifications
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