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Cat. No.: HY-126829

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Coumarin-SAHA

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Coumarin-SAHA is a fluorescent probe for determining the binding affinities (k_d) and the dissociation off-rates (k_off) of the HDAC8-inhibitor complexes.

For research use only. We do not sell to patients.

CAS No.: 1260635-77-5
Formula: C₁₈H₂₂N₂O₅
Molecular Weight:346.38

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Coumarin-SAHA Chemical Structure

CAS No.: 1260635-77-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Coumarin-SAHA is a fluorescent probe for determining the binding affinities (k_d) and the dissociation off-rates (k_off) of the HDAC8-inhibitor complexes^[1].

IC₅₀ & Target

HDAC8

All HDAC Isoforms :

Chemical Information

CAS No. 1260635-77-5
Appearance Solid
Molecular Weight 346.38
Formula C₁₈H₂₂N₂O₅
Color White to off-white
SMILES

O=C(NO)CCCCCCC(NC1=CC=C(C(O2)=C1)C(C)=CC2=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Raushan K Singh, et al. Coumarin-suberoylanilide hydroxamic acid as a fluorescent probe for determining binding affinities and off-rates of histone deacetylase inhibitors. Anal Biochem [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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Coumarin-SAHA

High-Throughput Bioactive Compound Library

All HDAC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Coumarin-SAHA Related Classifications

HY-126829 Related Classifications