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Cat. No.: HY-168148S

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CZL-046

CZL-046 (compund 29) is an oral p300 bromodomain inhibitor.

For research use only. We do not sell to patients.

CAS No.: 3032444-02-0
Formula: C₂₉H₂₆D₃F₃N₄O₃
Molecular Weight:541.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

CZL-046 Chemical Structure

CAS No.: 3032444-02-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

CZL-046 (compund 29) is an oral p300 bromodomain inhibitor^[1].

IC₅₀ & Target

p300^[1]

All Histone Acetyltransferase Isoforms :

All Epigenetic Reader Domain Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Hep 3B2	IC₅₀	2.704 μM Compound: 29; CZL-046	Antiproliferative activity against human Hep3B cells assessed as inhibition of cell proliferation incubated for 6 days by CCK-8 assay Antiproliferative activity against human Hep3B cells assessed as inhibition of cell proliferation incubated for 6 days by CCK-8 assay	[PMID: 39356741]
HepG2	IC₅₀	1.583 μM Compound: 29; CZL-046	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 6 days by CCK-8 assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 6 days by CCK-8 assay	[PMID: 39356741]
MOLT-4	IC₅₀	0.324 μM Compound: 29; CZL-046	Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell proliferation incubated for 6 days by CCK-8 assay Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell proliferation incubated for 6 days by CCK-8 assay	[PMID: 39356741]
OPM-2	IC₅₀	51.5 nM Compound: 29; CZL-046	Antiproliferative activity against human OPM-2 cells assessed as inhibition of cell proliferation incubated for 6 days by CCK8 assay Antiproliferative activity against human OPM-2 cells assessed as inhibition of cell proliferation incubated for 6 days by CCK8 assay	[PMID: 39356741]
RPMI-8226	IC₅₀	0.703 μM Compound: 29; CZL-046	Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell proliferation incubated for 6 days by CCK-8 assay Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell proliferation incubated for 6 days by CCK-8 assay	[PMID: 39356741]

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 3032444-02-0
Molecular Weight 541.58
Formula C₂₉H₂₆D₃F₃N₄O₃
SMILES

O=C1N([C@@H](C[C@@H]1F)C2=NC3=CC(C4=C(ON=C4C)C)=CC=C3N2[C@H]5CC[C@@H](CC5)OC([2H])([2H])[2H])C6=CC(F)=C(C=C6)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen Z, et al. Discovery of CZL-046 with an (S)-3-Fluoropyrrolidin-2-one Scaffold as a p300 Bromodomain Inhibitor for the Treatment of Multiple Myeloma. J Med Chem. 2024 Oct 24;67(20):18606-18628. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- Application
Chemical Information
Purity & Documentation
References

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CZL-046

All Histone Acetyltransferase Isoforms

All Epigenetic Reader Domain Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CZL-046 Related Classifications

HY-168148S Related Classifications