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Referencia número: HY-168148S

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CZL-046

CZL-046 (compund 29) is an oral p300 bromodomain inhibitor.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 3032444-02-0
Fòrmula: C₂₉H₂₆D₃F₃N₄O₃
Peso molecular:541.58

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

CZL-046 Chemical Structure

No. CAS: 3032444-02-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- Aplicación
Chemical Information
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Bioz

Actividad biológica

Descripciòn

CZL-046 (compund 29) is an oral p300 bromodomain inhibitor^[1].

IC₅₀ & Target

p300^[1]

Ver todos los productos específicos de isoformas Histone Acetyltransferase :

Ver todos los productos específicos de isoformas Epigenetic Reader Domain :

Cellular Effect

Cell Line	Type	Value	Description	References
Hep 3B2	IC₅₀	2.704 μM Compound: 29; CZL-046	Antiproliferative activity against human Hep3B cells assessed as inhibition of cell proliferation incubated for 6 days by CCK-8 assay Antiproliferative activity against human Hep3B cells assessed as inhibition of cell proliferation incubated for 6 days by CCK-8 assay	[PMID: 39356741]
HepG2	IC₅₀	1.583 μM Compound: 29; CZL-046	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 6 days by CCK-8 assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 6 days by CCK-8 assay	[PMID: 39356741]
MOLT-4	IC₅₀	0.324 μM Compound: 29; CZL-046	Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell proliferation incubated for 6 days by CCK-8 assay Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell proliferation incubated for 6 days by CCK-8 assay	[PMID: 39356741]
OPM-2	IC₅₀	51.5 nM Compound: 29; CZL-046	Antiproliferative activity against human OPM-2 cells assessed as inhibition of cell proliferation incubated for 6 days by CCK8 assay Antiproliferative activity against human OPM-2 cells assessed as inhibition of cell proliferation incubated for 6 days by CCK8 assay	[PMID: 39356741]
RPMI-8226	IC₅₀	0.703 μM Compound: 29; CZL-046	Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell proliferation incubated for 6 days by CCK-8 assay Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell proliferation incubated for 6 days by CCK-8 assay	[PMID: 39356741]

Aplicación

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

No. CAS 3032444-02-0
Peso molecular 541.58
Fòrmula C₂₉H₂₆D₃F₃N₄O₃
SMILES

O=C1N([C@@H](C[C@@H]1F)C2=NC3=CC(C4=C(ON=C4C)C)=CC=C3N2[C@H]5CC[C@@H](CC5)OC([2H])([2H])[2H])C6=CC(F)=C(C=C6)F
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Chen Z, et al. Discovery of CZL-046 with an (S)-3-Fluoropyrrolidin-2-one Scaffold as a p300 Bromodomain Inhibitor for the Treatment of Multiple Myeloma. J Med Chem. 2024 Oct 24;67(20):18606-18628. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Aplicación
Chemical Information
Pureza y Documentación
Referencias

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CZL-046

Ver todos los productos específicos de isoformas Histone Acetyltransferase

Ver todos los productos específicos de isoformas Epigenetic Reader Domain

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

CZL-046 Related Classifications

HY-168148S Related Classifications