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NEK2 - NIMA related kinase 2 Gene

Also Known as NLK1; RP67; NEK2A; HsPK21; PPP1R111

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4751

About NEK2

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:211,658,256-211,675,621 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues, 8 paralogues and is associated with 3 phenotypes. Biased expression in testis (RPKM 28.1), bone marrow (RPKM 3.8) and 6 other tissues.

Summary

This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011]

NEK2 Products (3)

mRNA	Protein	Name
NM_001204182.2	NP_001191111.1	serine/threonine-protein kinase Nek2 isoform 3
NM_001204183.2	NP_001191112.1	serine/threonine-protein kinase Nek2 isoform 2
NM_002497.4	NP_002488.1	serine/threonine-protein kinase Nek2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9647649	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	10880350	GOA
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	24554434	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	10880350	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in centrosome separation	IDA IDA: Inferred from direct assay	18086858	GOA
involved in chromosome segregation	IDA IDA: Inferred from direct assay	14978040	GOA
involved in negative regulation of centriole-centriole cohesion	IMP IMP: Inferred from mutant phenotype	24554434	GOA
acts upstream of or within positive regulation of telomere maintenance	IMP IMP: Inferred from mutant phenotype	21531765	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	17626005	GOA
involved in protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	10880350	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	21076410	GOA
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	24554434	GOA
involved in regulation of attachment of spindle microtubules to kinetochore	IMP IMP: Inferred from mutant phenotype	18297113	GOA
involved in regulation of mitotic centrosome separation	IMP IMP: Inferred from mutant phenotype	26220856	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
colocalizes with kinetochore	IDA IDA: Inferred from direct assay	17621308	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	14978040	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	10880350	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEK2 Protein Structure

Pkinase

0
100
200
300
400
445 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase Nek2	NIMA (never in mitosis gene a)-related kinase 2

NEK2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	NEK2	P51955	ANAPC4	Homo sapiens	Q9UJX5	Anti Bait CoIP	23288039
Intra	NEK2	P51955	KIF24	Homo sapiens	Q5T7B8	IF	26290419
Intra	NEK2	P51955	KIF24	Homo sapiens	Q5T7B8	Protein Kinase Assay	26290419
Intra	NEK2	P51955	MCC	Homo sapiens	P23508	Y2H	21900206
Intra	NEK2	P51955	PPP1CC	Homo sapiens	P36873-1	Far-WB	24116158
Intra	NEK2	P51955	PPP1CC	Homo sapiens	P36873-1	Y2H	21382349
Intra	NEK2	P51955	NEK11	Homo sapiens	Q8NG66	Pull Down	15161910
Intra	NEK2	P51955	CDC27	Homo sapiens	P30260	Anti Bait CoIP	16648845
Cross	NEK2	P51955	MGC80529	Crosspus laevis	Q6GQ04	Anti Bait CoIP	16648845

Cross: Cross-species interaction Intra: Intraspecies interaction

NEK2 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P82165	NEK2 Antibody (YA1910)	WB	Human

Related Diseases

Diseases	Alias
Retinitis Pigmentosa 67	RP67 Retinitis Pigmentosa, Type 67
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-120356A	T-1101 tosylate	Inhibitor	98.91%	Phase 1

Pre-clinical Phase

Bioactive Molecules (18)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-101029	MBM-55	Inhibitor	99.94%	Unkown
HY-16660	INH1	Inhibitor	99.85%	Unkown
HY-117154	INH154		99.89%	Unkown
HY-156437	NBI-961	Inhibitor	99.73%	Unkown
HY-116423	JH295		98.66%	Unkown
HY-100541	INH6	Inhibitor	99.53%	Unkown
HY-B0790	TAI-1	Inhibitor	98.60%	Unkown
HY-101030A	MBM-17S	Inhibitor	/	Unkown
HY-137046	Nek2-IN-4		/	Unkown
HY-116423A	JH295 hydrate		99.0%	Unkown
HY-153749	Nek2/Hec1-IN-2		98.0%	Unkown
HY-101029A	MBM-55S	Inhibitor	/	Unkown
HY-101030	MBM-17	Inhibitor	/	Unkown
HY-108919	CG-1521	Inhibitor	95.71%	Unkown
HY-111090	GSK461364 analogue 1	Inhibitor	/	Unkown
HY-150046	Nek2-IN-6		/	Unkown
HY-120356	T-1101	Inhibitor	/	Unkown
HY-120330	Nek2-IN-5		99.17%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NEK2	VGNC	VGNC:75308
Mus musculus	NEK2	MGD	MGI:109359
Canis familiaris	NEK2	VGNC	VGNC:43731
Bos taurus	NEK2	VGNC	VGNC:31993
Felis catus	NEK2	VGNC	VGNC:68456
Rattus norvegicus	NEK2	RGD	RGD:619792
Others	NEK2	NCBI