Antioxidant Agent

Hydroxytanshinone IIA is a hydrolytic metabolite of Tanshinone IIA (HY-N0135). Tanshinone IIA inhibits angiogenesis by targeting the protein kinase domain of VEGF/VEGFR2. Hydroxytanshinone IIA exhibits antioxidant and anti-inflammatory activities. Hydroxytanshinone IIA can be used in studies of angina pectoris and myocardial infarction.

Shepherdine, a harmala-type indole and tetrahydro-β-carboline alkaloid, is an antioxidant. Shepherdine scavenges free radicals via single electron transfer from its indole ring, forming an indolyl cation or neutral radical, and may convert to aromatic β-carbolines during this process. Shepherdine can be used for research on antioxidant activity.

Oxalic acid (Ethanedioic acid) diammonium monohydrate is a dicarboxylic acid found in a wide variety of plants.
Oxalic acid diammonium monohydrate shows antioxidant acyivity and suppresses lipid peroxidation.
Oxalic acid diammonium monohydrate is a pathogenicity factor for sclerotinia sclerotiorum, and suppresses the oxidative burst of the host plant. Oxalic acid diammonium monohydrate exerts acaricidal activity. Oxalic acid can be used for the researches of sclerotinia disease varroatosis and inflammatory diseases.

4-Hydroxydiphenylamine (p-Anilinophenol; 4-Hydroxy-DPA; 4-HDPA) is an aromatic amine organic compound. 4-Hydroxydiphenylamine exhibits antioxidant activity, and also acts as a catalyst or intermediate in certain chemical reactions to participate in the synthesis of other compounds. 4-Hydroxydiphenylamine can be used in research in the fields of environmental science and toxicology.

Violaxanthin is a naturally derived diepoxy xanthophyll carotenoid and light-harvesting accessory pigment with biological activities such as antioxidation and anti-inflammation. Violaxanthin transfers excitation energy to chlorophyll a under low-light conditions. Violaxanthin participates in the xanthophyll cycle and dissipates excess light energy in the form of heat, thereby protecting thylakoid membrane lipids from photo-oxidative damage. Violaxanthin exhibits activities including inhibition of lipid peroxidation, quenching of singlet oxygen, scavenging of DPPH free radicals, and scavenging of ABTS⁺ free radicals. Violaxanthin can be used in antioxidant-related research.

MAO-B-IN-64 is an orally active, blood-brain barrier-permeable reversible competitive inhibitor of monoamine oxidase B, with an IC₅₀ of 0.35 nM against human MAO-B and a K_i of 0.22 nM for human MAO-B. MAO-B-IN-64 exhibits antioxidant effects by scavenging free radicals. MAO-B-IN-64 exerts anti-neuroinflammatory effects by inhibiting the release of pro-inflammatory factors. MAO-B-IN-64 acts as an H₂S donor by releasing hydrogen sulfide. MAO-B-IN-64 can be applied in the research of Parkinson's disease.

(E)-m-Coumaric acid (Standard) (trans-3-Hydroxycinnamic acid (Standard)) is the analytical standard of (E)-m-Coumaric acid (HY-N7127). This product is intended for research and analytical applications. (E)-m-Coumaric acid (trans-3-Hydroxycinnamic acid) is a natural phenolic cinnamic acid derivative with antioxidant activity, and it is found in the young shoots of Limonium densiflorum. (E)-m-Coumaric acid upregulates the levels of SOD and GSH and reduces MDA levels, thereby alleviating oxidative stress and lipid peroxidation in liver tissue. (E)-m-Coumaric acid can be used in studies related to oxidative stress-mediated liver injury.

Levocarnitine propionate hydrochloride (Standard) is the analytical standard of Adrenalone (hydrochloride). This product is intended for research and analytical applications. Levocarnitine propionate hydrochloride (L-Propionylcarnitine chloride; ST-261) is a ligand of carnitine acetyltransferase (CAT) with high enzyme affinity. Levocarnitine propionate hydrochloride possesses antioxidant activity. Levocarnitine propionate hydrochloride increases intracellular L-carnitine reserves. Levocarnitine propionate hydrochloride exerts a protective effect against myocardial ischemia-reperfusion injury. Levocarnitine propionate hydrochloride can be used in research related to myocardial ischemia-reperfusion injury and chronic ischemic heart disease.

Mesaconic acid (Standard) is the analytical standard of Mesaconic acid. This product is intended for research and analytical applications. Mesaconic acid (Citronic acid; Methylfumaric acid) is an orally active anti-inflammatory and antioxidant agent. Mesaconic acid reduces the level of NF-κB in colon tissues, downregulates the expression of Keap1 and Bax, upregulates the expression of Nrf2 and Bcl2, and decreases the expression of Caspase-1. Mesaconic acid reduces the levels of NLRP3, ASC and Casp-1 in colon, liver and kidney tissues. Mesaconic acid reduces pro-inflammatory cytokine levels, increases the level of the anti-inflammatory cytokine IL-10, elevates NAD⁺ levels, regulates oxidative stress markers and antioxidant enzyme levels, and upregulates intestinal barrier proteins in colon, liver and kidney tissues. Mesaconic acid increases the abundance of beneficial gut bacteria and reduces the abundance of harmful gut bacteria in rapidly aging mice, and exhibits anti-aging properties. Mesaconic acid acts as a flame retardant and serves as a competitive inhibitor of fumarate reduction. Mesaconic acid can be used in the research of aging-related inflammation.

H-Hyp-Leu-OH is a linear dipeptide of hydroxyproline-leucine with anti-inflammatory and antioxidant activities. H-Hyp-Leu-OH inhibits NO, IL-1β, IL-6, and TNF-α in macrophages, and upregulates IL-10. H-Hyp-Leu-OH extends lifespan, improves exercise capacity, reduces ROS and MDA, and increases SOD, CAT, and GSH-Px. H-Hyp-Leu-OH can be used for epithelial ovarian cancer and antioxidant-related research.

Antibacterial agent 376 is an antibacterial agent. Antibacterial agent 376 exhibits antibacterial efficacy against S. aureus and E. coli. Antibacterial agent 376 induces mild hepatic alterations, including slight inflammatory cell infiltration, moderate vacuolar degeneration, and moderate hepatocyte enlargement, while the overall liver architecture remains largely preserved. Antibacterial agent 376 induces mild renal alterations, including vascular congestion, limited inflammatory cell infiltration, and mild tubular degeneration, while the overall kidney structure remains intact. Antibacterial agent 376 causes a significant decrease in serum antioxidant markers GSH, GPx, and CAT, indicating the induction of oxidative stress in rats. Antibacterial agent 376 can be used for research on bacterial infections (Staphylococcus aureus and Escherichia coli).

Pirenoxine sodium (Catalin K sodium) is an antioxidant with lens-protective activity. Pirenoxine sodium inhibits lens sclerosis, prevents lipid peroxidation and suppresses lens protein opacification. Pirenoxine sodium blocks benzoquinone acetic acid-induced cataract progression. Pirenoxine sodium can be used in research related to presbyopia and cataracts.

BChE-IN-55 is a reversible competitive inhibitor of butyrylcholinesterase (BChE) and acetylcholinesterase (AChE), with IC₅₀ values of 2.91 μM (eqBChE) and 34.42 μM (eeAChE), respectively. BChE-IN-55 exhibits antioxidant activity. BChE-IN-55 can be used for research on Alzheimer's disease.

Antimalarial agent-71 is an antimalarial agent and antioxidant. Antimalarial agent-71 is computationally predicted to bind within the PfNDH2 binding pocket, which is located on the type II NADH dehydrogenase of the mitochondrial electron transport chain. Antimalarial agent-71 inhibits the growth of Plasmodium falciparum 3D7 parasites in whole-cell assays. Antimalarial agent-71 scavenges DPPH free radicals. Antimalarial agent-71 can be used in research on malaria and antioxidation.

Scoparin is a C-glycosylflavone (chrysoeriol-8-C-glucoside) present in the juices of Citrus sinensis cultivars Sanguinello and Moro, as well as Citrus bergamia Risso and Citrus limetta Risso. Scoparin exhibits antioxidant activity.

Eleocharin D is a flavanone isolated from chufa (Eleocharis tuberosa) peels and a DPPH radical scavenging inhibitor. Eleocharin D exhibits weak radical scavenging activity.

Nobilin E is a bibenzyl derivative isolated from the stems of Dendrobium nobile. Nobilin E exerts scavenger effects through DPPH radical scavenging and ORAC peroxyl radical scavenging. Nobilin E inhibits NO production in LPS/IFN-γ-activated mouse macrophages.

Talienbisflavan A is a free radical scavenger found in green tea made from the leaves of Camellia taliensis. Talienbisflavan A mediates DPPH radical scavenging activity. Talienbisflavan A mediates ABTS⁺ radical scavenging activity. Talienbisflavan A exhibits antioxidant activity.

Hexadecyl ferulate is a lipophilic C16 alkyl ferulate synthesized from ferulic acid and cetyl alcohol, possessing free radical-scavenging antioxidant activity. Hexadecyl ferulate inhibits the formation of lipid oxidation products in soybean oil during deep frying and exhibits antioxidant efficacy that increases with alkyl chain length. Hexadecyl ferulate can be used in antioxidant-related research.

Eleocharin A is an isoprenylated flavonoid compound found in the pericarp of Eleocharis tuberosa and the twigs of Artocarpus nigrifolius. Eleocharin A exhibits DPPH radical scavenging activity and reducing power antioxidant activity. Eleocharin A exerts cytotoxic effects on cancer cells. Eleocharin A can be used in research on cervical cancer and gastric cancer.