Antimicrobial agent-54

Antimicrobial agent-54 (compound 10b) inhibits the growth of E. coli ATCC 8739 (MIC = 0.20 μM) in vitro^[1].
Antimicrobial agent-54 activates the SOS DNA damage response in Bacillus subtilis UG10, which is evidenced by the formation of RecA aggregates^[1].
Antimicrobial agent-54 induces cell elongation, nucleoid condensation, nucleoid-free regions and abnormal cell branching in E. coli W3110, a phenotype consistent with topoisomerase inhibition and potential impairment of penicillin-binding protein function^[1].
Antimicrobial agent-54 potently inhibits E. coli DNA gyrase (IC₅₀ = 0.18 μM) and S. aureus topoisomerase IV (IC₅₀ = 3.501 μM), while exhibits low activity against human topoisomerase II (IC₅₀ = 48.05 μM), showing excellent selectivity^[1].
Antimicrobial agent-54 potently inhibits nickel-dependent urease with an IC₅₀ value of 6.254 μM^[1].
Antimicrobial agent-54 potently inhibits E. coli LpxC with an IC₅₀ value of 0.052 μM^[1].
Antimicrobial agent-54 (20 days) exhibits extremely low potential for resistance development against E. coli NCTC 13476 over 20 days, with only a slight increase in its MIC^[1].
Antimicrobial agent-54 exhibits low cytotoxicity against human SH-SY5Y (IC₅₀ = 49.62 μM) and WI-38 (IC₅₀ = 59.35 μM) cells, with a favorable selectivity index of 17^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.