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Cat. No.: HY-168463

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Y16524

Y16524 is a potent inhibitor of CBP/p300 bromodomain , with the IC₅₀ of 0.01 μM. Y16524 has the potential for the research of acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

CAS No.: 3109988-90-8
Formula: C₃₀H₃₄ClN₅O₄
Molecular Weight:564.08

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Y16524 Chemical Structure

CAS No.: 3109988-90-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Y16524 is a potent inhibitor of CBP/p300 bromodomain , with the IC₅₀ of 0.01 μM. Y16524 has the potential for the research of acute myeloid leukemia (AML)^[1].

All Histone Acetyltransferase Isoforms :

All Epigenetic Reader Domain Isoforms :

Chemical Information

CAS No. 3109988-90-8
Molecular Weight 564.08
Formula C₃₀H₃₄ClN₅O₄
SMILES

COC1=CC=C(N([C@H](C2=NC(C3=CC=C(ON=C4C)C4=C3)=CN2C[C@H](C)N5CCOCC5)CCC6)C6=O)C=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jian-Kang Hu, et al. Discovery of 5-imidazole-3-methylbenz[d]isoxazole derivatives as potent and selective CBP/p300 bromodomain inhibitors for the treatment of acute myeloid leukemia. Acta Pharmacol Sin. 2025 Jan 31. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Protocols
Purity & Documentation
References

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Y16524

All Histone Acetyltransferase Isoforms

All Epigenetic Reader Domain Isoforms