2. Epigenetics
  3. Histone Methyltransferase
  4. EPZ028862

EPZ028862 is a selective SMYD3 inhibitor for cancer research.

For research use only. We do not sell to patients.

EPZ028862 Chemical Structure

EPZ028862 Chemical Structure

CAS No. : 1887082-53-2

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Description

EPZ028862 is a selective SMYD3 inhibitor for cancer research[1].

In Vivo

The pharmacokinetic parameters of EPZ028862( IV: 1 mg/kg; PO: 5 mg/kg)

Parameter Mouse Rat Dog Cynomolgus
CLp(mL/min/kg) 79.8 32.7 13.9 21.4
CLr(mL/min/kg) 23.6 21 1.97 1.06
Vss(L/kg) 9.5 4.4 5.8 9.5
t1/2(h) 2 2.1 5.4 5.6
MRT(h) 2 59 7 7.4
tmax(h) 0.33 1 1.5 2
F(%) 100 59 70 62

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

422.54

Formula

C20H30N4O4S
CAS No.
SMILES

O=[S](N([C@H]1C2)[C@@H](CC1)C[C@H]2NC(C3=NOC(C4CC4)=C3)=O)([C@@H](CC5)CC[C@H]5N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EPZ028862 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EPZ0288621887082-53-2EPZ 028862EPZ-028862Histone MethyltransferaseSMYD3cancerInhibitorinhibitorinhibit

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