EPZ032597

Cat. No.: HY-169113: Data Sheet Handling Instructions
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EPZ032597 is a selective and noncompetitive SMYD2 inhibitor with an IC₅₀ value of 16 nM. EPZ032597 is promising for research of pancreatic ductal adenocarcinoma.

For research use only. We do not sell to patients.

EPZ032597 Chemical Structure

CAS No. : 1887193-58-9

Size	Stock	Quantity
1 mg	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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•Related Small Molecules:

•Related Proteins:

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms

EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

Biological Activity
Purity & Documentation
References
Customer Review

Description

EPZ032597 is a selective and noncompetitive SMYD2 inhibitor with an IC₅₀ value of 16 nM. EPZ032597 is promising for research of pancreatic ductal adenocarcinoma^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
5637	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human 5637 cells after 10 days Antiproliferative activity against human 5637 cells after 10 days	[PMID: 29856759]
639-V	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human 639-V cells after 10 days Antiproliferative activity against human 639-V cells after 10 days	[PMID: 29856759]
647-V	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human 647-V cells after 10 days Antiproliferative activity against human 647-V cells after 10 days	[PMID: 29856759]
769-P	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human 769-P cells after 10 days Antiproliferative activity against human 769-P cells after 10 days	[PMID: 29856759]
786-0	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human 786-0 cells after 10 days Antiproliferative activity against human 786-0 cells after 10 days	[PMID: 29856759]
A 172	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human A-172 cells after 10 days Antiproliferative activity against human A-172 cells after 10 days	[PMID: 29856759]
A-375	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human A-375 cells after 10 days Antiproliferative activity against human A-375 cells after 10 days	[PMID: 29856759]
A-427	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human A-427 cells after 10 days Antiproliferative activity against human A-427 cells after 10 days	[PMID: 29856759]
A-431	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human A-431 cells after 10 days Antiproliferative activity against human A-431 cells after 10 days	[PMID: 29856759]
A101D	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human A101D cells after 10 days Antiproliferative activity against human A101D cells after 10 days	[PMID: 29856759]
A204	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human A204 cells after 10 days Antiproliferative activity against human A204 cells after 10 days	[PMID: 29856759]
A498	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human A498 cells after 10 days Antiproliferative activity against human A498 cells after 10 days	[PMID: 29856759]
A549	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human A549 cells after 10 days Antiproliferative activity against human A549 cells after 10 days	[PMID: 29856759]
A673	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human A673 cells after 10 days Antiproliferative activity against human A673 cells after 10 days	[PMID: 29856759]
ACHN	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human ACHN cells after 10 days Antiproliferative activity against human ACHN cells after 10 days	[PMID: 29856759]
AGS	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human AGS cells after 10 days Antiproliferative activity against human AGS cells after 10 days	[PMID: 29856759]
AN3-CA	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human AN3-CA cells after 10 days Antiproliferative activity against human AN3-CA cells after 10 days	[PMID: 29856759]
ARH-77	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human ARH-77 cells after 10 days Antiproliferative activity against human ARH-77 cells after 10 days	[PMID: 29856759]
ASPC1	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human ASPC1 cells after 10 days Antiproliferative activity against human ASPC1 cells after 10 days	[PMID: 29856759]
AU565	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human AU565 cells after 10 days Antiproliferative activity against human AU565 cells after 10 days	[PMID: 29856759]
BFTC-905	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human BFTC-905 cells after 10 days Antiproliferative activity against human BFTC-905 cells after 10 days	[PMID: 29856759]
BHT-101	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human BHT-101 cells after 10 days Antiproliferative activity against human BHT-101 cells after 10 days	[PMID: 29856759]
BPH-1	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human BPH-1 cells after 10 days Antiproliferative activity against human BPH-1 cells after 10 days	[PMID: 29856759]
BT-20	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human BT-20 cells after 10 days Antiproliferative activity against human BT-20 cells after 10 days	[PMID: 29856759]
BT-474	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human BT-474 cells after 10 days Antiproliferative activity against human BT-474 cells after 10 days	[PMID: 29856759]
BT-549	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human BT-549 cells after 10 days Antiproliferative activity against human BT-549 cells after 10 days	[PMID: 29856759]
BV-173	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human BV-173 cells after 10 days Antiproliferative activity against human BV-173 cells after 10 days	[PMID: 29856759]
BXPC-3	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human BXPC-3 cells after 10 days Antiproliferative activity against human BXPC-3 cells after 10 days	[PMID: 29856759]
BeWo	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human BeWo cells after 10 days Antiproliferative activity against human BeWo cells after 10 days	[PMID: 29856759]
C-33-A	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human C-33-A cells after 10 days Antiproliferative activity against human C-33-A cells after 10 days	[PMID: 29856759]
C-4-II	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human C-4-II cells after 10 days Antiproliferative activity against human C-4-II cells after 10 days	[PMID: 29856759]
C32	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human C32 cells after 10 days Antiproliferative activity against human C32 cells after 10 days	[PMID: 29856759]
CAKI-1	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CAKI-1 cells after 10 days Antiproliferative activity against human CAKI-1 cells after 10 days	[PMID: 29856759]
CAKI-2	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CAKI-2 cells after 10 days Antiproliferative activity against human CAKI-2 cells after 10 days	[PMID: 29856759]
CAL-27	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CAL-27 cells after 10 days Antiproliferative activity against human CAL-27 cells after 10 days	[PMID: 29856759]
CAL-62	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CAL-62 cells after 10 days Antiproliferative activity against human CAL-62 cells after 10 days	[PMID: 29856759]
CAMA-1	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CAMA-1 cells after 10 days Antiproliferative activity against human CAMA-1 cells after 10 days	[PMID: 29856759]
CAPAN-1	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CAPAN-1 cells after 10 days Antiproliferative activity against human CAPAN-1 cells after 10 days	[PMID: 29856759]
CCF-STTG1	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CCF-STTG1 cells after 10 days Antiproliferative activity against human CCF-STTG1 cells after 10 days	[PMID: 29856759]
CCRF-CEM	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CCRF-CEM cells after 10 days Antiproliferative activity against human CCRF-CEM cells after 10 days	[PMID: 29856759]
CFPAC-1	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CFPAC-1 cells after 10 days Antiproliferative activity against human CFPAC-1 cells after 10 days	[PMID: 29856759]
CGTH-W-1	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CGTH-W-1 cells after 10 days Antiproliferative activity against human CGTH-W-1 cells after 10 days	[PMID: 29856759]
CHL-1	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CHL-1 cells after 10 days Antiproliferative activity against human CHL-1 cells after 10 days	[PMID: 29856759]
CHP-212	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CHP-212 cells after 10 days Antiproliferative activity against human CHP-212 cells after 10 days	[PMID: 29856759]
COLO 201	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human COLO201 cells after 10 days Antiproliferative activity against human COLO201 cells after 10 days	[PMID: 29856759]
COLO 205	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human COLO 205 cells after 10 days Antiproliferative activity against human COLO 205 cells after 10 days	[PMID: 29856759]
COLO 320DM	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human COLO 320DM cells after 10 days Antiproliferative activity against human COLO 320DM cells after 10 days	[PMID: 29856759]
COLO-320-HSR	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human COLO 320HSR cells after 10 days Antiproliferative activity against human COLO 320HSR cells after 10 days	[PMID: 29856759]
COLO-829	IC₅₀	5.73 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human COLO-829 cells after 10 days Antiproliferative activity against human COLO-829 cells after 10 days	[PMID: 29856759]
COR-L105	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human COR-L105 cells after 10 days Antiproliferative activity against human COR-L105 cells after 10 days	[PMID: 29856759]
COR-L23	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human COR-L23 cells after 10 days Antiproliferative activity against human COR-L23 cells after 10 days	[PMID: 29856759]
CRO-AP2	IC₅₀	0.075 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human CRO-AP2 cells after 10 days Antiproliferative activity against human CRO-AP2 cells after 10 days	[PMID: 29856759]
CWR22R	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human 22Rv1 cells after 10 days Antiproliferative activity against human 22Rv1 cells after 10 days	[PMID: 29856759]
Calu-1	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Calu-1 cells after 10 days Antiproliferative activity against human Calu-1 cells after 10 days	[PMID: 29856759]
Calu-6	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Calu-6 cells after 10 days Antiproliferative activity against human Calu-6 cells after 10 days	[PMID: 29856759]
Capan-2	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Capan2 cells after 10 days Antiproliferative activity against human Capan2 cells after 10 days	[PMID: 29856759]
ChaGo-K-1	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human ChaGo-K-1 cells after 10 days Antiproliferative activity against human ChaGo-K-1 cells after 10 days	[PMID: 29856759]
D283 Med	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human D283 Med cells after 10 days Antiproliferative activity against human D283 Med cells after 10 days	[PMID: 29856759]
DB	IC₅₀	0.663 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human DB cells after 10 days Antiproliferative activity against human DB cells after 10 days	[PMID: 29856759]
DBTRG-05MG	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human DBTRG-05MG cells after 10 days Antiproliferative activity against human DBTRG-05MG cells after 10 days	[PMID: 29856759]
DK-MG	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human DK-MG cells after 10 days Antiproliferative activity against human DK-MG cells after 10 days	[PMID: 29856759]
DLD-1	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human DLD-1 cells after 10 days Antiproliferative activity against human DLD-1 cells after 10 days	[PMID: 29856759]
DMS-114	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human DMS-114 cells after 10 days Antiproliferative activity against human DMS-114 cells after 10 days	[PMID: 29856759]
DMS-273	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human DMS-273 cells after 10 days Antiproliferative activity against human DMS-273 cells after 10 days	[PMID: 29856759]
DMS-53	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human DMS-53 cells after 10 days Antiproliferative activity against human DMS-53 cells after 10 days	[PMID: 29856759]
DOHH-2	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human DOHH-2 cells after 10 days Antiproliferative activity against human DOHH-2 cells after 10 days	[PMID: 29856759]
DU-145	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human DU-145 cells after 10 days Antiproliferative activity against human DU-145 cells after 10 days	[PMID: 29856759]
Daoy	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Daoy cells after 10 days Antiproliferative activity against human Daoy cells after 10 days	[PMID: 29856759]
Daudi	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Daudi cells after 10 days Antiproliferative activity against human Daudi cells after 10 days	[PMID: 29856759]
Detroit 562	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Detroit 562 cells after 10 days Antiproliferative activity against human Detroit 562 cells after 10 days	[PMID: 29856759]
DoTc2-4510	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human DoTc2-4510 cells after 10 days Antiproliferative activity against human DoTc2-4510 cells after 10 days	[PMID: 29856759]
EB-3	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human EB-3 cells after 10 days Antiproliferative activity against human EB-3 cells after 10 days	[PMID: 29856759]
EFM-19	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human EFM-19 cells after 10 days Antiproliferative activity against human EFM-19 cells after 10 days	[PMID: 29856759]
EM-2	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human EM-2 cells after 10 days Antiproliferative activity against human EM-2 cells after 10 days	[PMID: 29856759]
ES-2	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human ES2 cells after 10 days Antiproliferative activity against human ES2 cells after 10 days	[PMID: 29856759]
FaDu	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human FaDu cells after 10 days Antiproliferative activity against human FaDu cells after 10 days	[PMID: 29856759]
G-401	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human G-401 cells after 10 days Antiproliferative activity against human G-401 cells after 10 days	[PMID: 29856759]
G-402	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human G-402 cells after 10 days Antiproliferative activity against human G-402 cells after 10 days	[PMID: 29856759]
H4	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human H4 cells after 10 days Antiproliferative activity against human H4 cells after 10 days	[PMID: 29856759]
HCT-116	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HCT-116 cells after 10 days Antiproliferative activity against human HCT-116 cells after 10 days	[PMID: 29856759]
HCT-15	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HCT-15 cells after 10 days Antiproliferative activity against human HCT-15 cells after 10 days	[PMID: 29856759]
HCT-8	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HCT-8 cells after 10 days Antiproliferative activity against human HCT-8 cells after 10 days	[PMID: 29856759]
HEC-1-A	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HEC-1-A cells after 10 days Antiproliferative activity against human HEC-1-A cells after 10 days	[PMID: 29856759]
HEL 92.1.7	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HEL 92.1.7 cells after 10 days Antiproliferative activity against human HEL 92.1.7 cells after 10 days	[PMID: 29856759]
HLE	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HLE cells after 10 days Antiproliferative activity against human HLE cells after 10 days	[PMID: 29856759]
HOS	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HOS cells after 10 days Antiproliferative activity against human HOS cells after 10 days	[PMID: 29856759]
HPAF-II	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HPAF-II cells after 10 days Antiproliferative activity against human HPAF-II cells after 10 days	[PMID: 29856759]
HT	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HT cells after 10 days Antiproliferative activity against human HT cells after 10 days	[PMID: 29856759]
HT-1080	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HT-1080 cells after 10 days Antiproliferative activity against human HT-1080 cells after 10 days	[PMID: 29856759]
HT-1376	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HT-1376 cells after 10 days Antiproliferative activity against human HT-1376 cells after 10 days	[PMID: 29856759]
HT-29	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HT-29 cells after 10 days Antiproliferative activity against human HT-29 cells after 10 days	[PMID: 29856759]
HT-3	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HT-3 cells after 10 days Antiproliferative activity against human HT-3 cells after 10 days	[PMID: 29856759]
HT1197	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HT1197 cells after 10 days Antiproliferative activity against human HT1197 cells after 10 days	[PMID: 29856759]
HUH-6-clone5	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HUH-6-clone5 cells after 10 days Antiproliferative activity against human HUH-6-clone5 cells after 10 days	[PMID: 29856759]
HeLa	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HeLa cells after 10 days Antiproliferative activity against human HeLa cells after 10 days	[PMID: 29856759]
HepG2	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HepG2 cells after 10 days Antiproliferative activity against human HepG2 cells after 10 days	[PMID: 29856759]
Hs 294T	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Hs 294T cells after 10 days Antiproliferative activity against human Hs 294T cells after 10 days	[PMID: 29856759]
Hs 695T	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Hs 695T cells after 10 days Antiproliferative activity against human Hs 695T cells after 10 days	[PMID: 29856759]
Hs 766	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Hs766T cells after 10 days Antiproliferative activity against human Hs766T cells after 10 days	[PMID: 29856759]
Hs-578T	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Hs 578T cells after 10 days Antiproliferative activity against human Hs 578T cells after 10 days	[PMID: 29856759]
Hs746T	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Hs746T cells after 10 days Antiproliferative activity against human Hs746T cells after 10 days	[PMID: 29856759]
HuCCT-1	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HuCCT-1 cells after 10 days Antiproliferative activity against human HuCCT-1 cells after 10 days	[PMID: 29856759]
HuP-T4	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human HuP-T4 cells after 10 days Antiproliferative activity against human HuP-T4 cells after 10 days	[PMID: 29856759]
J-RT3-T3-5	IC₅₀	0.003 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human J-RT3-T3-5 cells after 10 days Antiproliferative activity against human J-RT3-T3-5 cells after 10 days	[PMID: 29856759]
J82	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human J82 cells after 10 days Antiproliferative activity against human J82 cells after 10 days	[PMID: 29856759]
JAR	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human JAR cells after 10 days Antiproliferative activity against human JAR cells after 10 days	[PMID: 29856759]
JEG-3	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human JEG-3 cells after 10 days Antiproliferative activity against human JEG-3 cells after 10 days	[PMID: 29856759]
Jurkat	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Jurkat cells after 10 days Antiproliferative activity against human Jurkat cells after 10 days	[PMID: 29856759]
K562	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human K562 cells after 10 days Antiproliferative activity against human K562 cells after 10 days	[PMID: 29856759]
KLE	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human KLE cells after 10 days Antiproliferative activity against human KLE cells after 10 days	[PMID: 29856759]
L-428	IC₅₀	2.61 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human L-428 cells after 10 days Antiproliferative activity against human L-428 cells after 10 days	[PMID: 29856759]
LNCaP	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human LNCaP cells after 10 days Antiproliferative activity against human LNCaP cells after 10 days	[PMID: 29856759]
LS-1034	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human LS1034 cells after 10 days Antiproliferative activity against human LS1034 cells after 10 days	[PMID: 29856759]
LS174T	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human LS174T cells after 10 days Antiproliferative activity against human LS174T cells after 10 days	[PMID: 29856759]
MC-IXC	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MC-IXC cells after 10 days Antiproliferative activity against human MC-IXC cells after 10 days	[PMID: 29856759]
MCF7	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MCF7 cells after 10 days Antiproliferative activity against human MCF7 cells after 10 days	[PMID: 29856759]
MDA-MB-231	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MDA-MB-231 cells after 10 days Antiproliferative activity against human MDA-MB-231 cells after 10 days	[PMID: 29856759]
MDA-MB-436	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MDA-MB-436 cells after 10 days Antiproliferative activity against human MDA-MB-436 cells after 10 days	[PMID: 29856759]
MDA-MB-453	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MDA-MB-453 cells after 10 days Antiproliferative activity against human MDA-MB-453 cells after 10 days	[PMID: 29856759]
MDA-MB-468	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MDA-MB-468 cells after 10 days Antiproliferative activity against human MDA-MB-468 cells after 10 days	[PMID: 29856759]
MEG-01	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MEG-01 cells after 10 days Antiproliferative activity against human MEG-01 cells after 10 days	[PMID: 29856759]
MES-SA	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MES-SA cells after 10 days Antiproliferative activity against human MES-SA cells after 10 days	[PMID: 29856759]
MG-63	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MG-63 cells after 10 days Antiproliferative activity against human MG-63 cells after 10 days	[PMID: 29856759]
MHH-PREB-1	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MHH-PREB-1 cells after 10 days Antiproliferative activity against human MHH-PREB-1 cells after 10 days	[PMID: 29856759]
MIA PaCa-2	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Mia PaCa-2 cells after 10 days Antiproliferative activity against human Mia PaCa-2 cells after 10 days	[PMID: 29856759]
MOLT-16	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MOLT-16 cells after 10 days Antiproliferative activity against human MOLT-16 cells after 10 days	[PMID: 29856759]
MOLT-3	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MOLT-3 cells after 10 days Antiproliferative activity against human MOLT-3 cells after 10 days	[PMID: 29856759]
MV4-11	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MV4-11 cells after 10 days Antiproliferative activity against human MV4-11 cells after 10 days	[PMID: 29856759]
MX1	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MX1 cells after 10 days Antiproliferative activity against human MX1 cells after 10 days	[PMID: 29856759]
Malme-3M	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Malme-3M cells after 10 days Antiproliferative activity against human Malme-3M cells after 10 days	[PMID: 29856759]
MeWo	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human MeWo cells after 10 days Antiproliferative activity against human MeWo cells after 10 days	[PMID: 29856759]
NALM-6	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human NALM-6 cells after 10 days Antiproliferative activity against human NALM-6 cells after 10 days	[PMID: 29856759]
NCI-H292	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human NCI-H292 cells after 10 days Antiproliferative activity against human NCI-H292 cells after 10 days	[PMID: 29856759]
NCI-H295R	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human NCI-H295R cells after 10 days Antiproliferative activity against human NCI-H295R cells after 10 days	[PMID: 29856759]
NCI-H441	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human NCI-H441 cells after 10 days Antiproliferative activity against human NCI-H441 cells after 10 days	[PMID: 29856759]
NCI-H446	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human NCI-H446 cells after 10 days Antiproliferative activity against human NCI-H446 cells after 10 days	[PMID: 29856759]
NCI-H460	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human NCI-H460 cells after 10 days Antiproliferative activity against human NCI-H460 cells after 10 days	[PMID: 29856759]
NCI-H508	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human NCI-H508 cells after 10 days Antiproliferative activity against human NCI-H508 cells after 10 days	[PMID: 29856759]
NCI-H520	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human NCI-H520 cells after 10 days Antiproliferative activity against human NCI-H520 cells after 10 days	[PMID: 29856759]
NCI-H596	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human NCI-H596 cells after 10 days Antiproliferative activity against human NCI-H596 cells after 10 days	[PMID: 29856759]
NCI-H661	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human NCI-H661 cells after 10 days Antiproliferative activity against human NCI-H661 cells after 10 days	[PMID: 29856759]
NCI-H69	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human NCI-H69 cells after 10 days Antiproliferative activity against human NCI-H69 cells after 10 days	[PMID: 29856759]
NCI-H747	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human NCI-H747 cells after 10 days Antiproliferative activity against human NCI-H747 cells after 10 days	[PMID: 29856759]
OE19	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human OE19 cells after 10 days Antiproliferative activity against human OE19 cells after 10 days	[PMID: 29856759]
OE33	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human OE33 cells after 10 days Antiproliferative activity against human OE33 cells after 10 days	[PMID: 29856759]
OVCAR-3	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human OVCAR-3 cells after 10 days Antiproliferative activity against human OVCAR-3 cells after 10 days	[PMID: 29856759]
PANC-1	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human PANC-1 cells after 10 days Antiproliferative activity against human PANC-1 cells after 10 days	[PMID: 29856759]
PC-3	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human PC-3 cells after 10 days Antiproliferative activity against human PC-3 cells after 10 days	[PMID: 29856759]
RD	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human RD cells after 10 days Antiproliferative activity against human RD cells after 10 days	[PMID: 29856759]
RKO	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human RKO cells after 10 days Antiproliferative activity against human RKO cells after 10 days	[PMID: 29856759]
RL95-2	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human RL95-2 cells after 10 days Antiproliferative activity against human RL95-2 cells after 10 days	[PMID: 29856759]
RPMI-6666	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human RPMI-6666 cells after 10 days Antiproliferative activity against human RPMI-6666 cells after 10 days	[PMID: 29856759]
RPMI-7951	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human RPMI-7951 cells after 10 days Antiproliferative activity against human RPMI-7951 cells after 10 days	[PMID: 29856759]
RPMI-8226	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human RPMI-8226 cells after 10 days Antiproliferative activity against human RPMI-8226 cells after 10 days	[PMID: 29856759]
Raji	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Raji cells after 10 days Antiproliferative activity against human Raji cells after 10 days	[PMID: 29856759]
Ramos	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Ramos cells after 10 days Antiproliferative activity against human Ramos cells after 10 days	[PMID: 29856759]
SAOS-2	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SAOS-2 cells after 10 days Antiproliferative activity against human SAOS-2 cells after 10 days	[PMID: 29856759]
SCC-25	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SCC-25 cells after 10 days Antiproliferative activity against human SCC-25 cells after 10 days	[PMID: 29856759]
SCC-4	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SCC-4 cells after 10 days Antiproliferative activity against human SCC-4 cells after 10 days	[PMID: 29856759]
SCC-9	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SCC-9 cells after 10 days Antiproliferative activity against human SCC-9 cells after 10 days	[PMID: 29856759]
SCaBER	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SCaBER cells after 10 days Antiproliferative activity against human SCaBER cells after 10 days	[PMID: 29856759]
SH-4	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SH-4 cells after 10 days Antiproliferative activity against human SH-4 cells after 10 days	[PMID: 29856759]
SHP77	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SHP77 cells after 10 days Antiproliferative activity against human SHP77 cells after 10 days	[PMID: 29856759]
SJRH30	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SJRH30 cells after 10 days Antiproliferative activity against human SJRH30 cells after 10 days	[PMID: 29856759]
SJSA-1	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SJSA-1 cells after 10 days Antiproliferative activity against human SJSA-1 cells after 10 days	[PMID: 29856759]
SK-BR-3	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SK-BR-3 cells after 10 days Antiproliferative activity against human SK-BR-3 cells after 10 days	[PMID: 29856759]
SK-LMS-1	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SK-LMS-1 cells after 10 days Antiproliferative activity against human SK-LMS-1 cells after 10 days	[PMID: 29856759]
SK-MEL-1	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SK-MEL-1 cells after 10 days Antiproliferative activity against human SK-MEL-1 cells after 10 days	[PMID: 29856759]
SK-MEL-28	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SK-MEL-28 cells after 10 days Antiproliferative activity against human SK-MEL-28 cells after 10 days	[PMID: 29856759]
SK-MEL3	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SK-MEL3 cells after 10 days Antiproliferative activity against human SK-MEL3 cells after 10 days	[PMID: 29856759]
SK-MES-1	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SK-MES-1 cells after 10 days Antiproliferative activity against human SK-MES-1 cells after 10 days	[PMID: 29856759]
SK-N-AS	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SK-N-AS cells after 10 days Antiproliferative activity against human SK-N-AS cells after 10 days	[PMID: 29856759]
SK-N-DZ	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SK-N-DZ cells after 10 days Antiproliferative activity against human SK-N-DZ cells after 10 days	[PMID: 29856759]
SK-N-FI	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SK-N-FI cells after 10 days Antiproliferative activity against human SK-N-FI cells after 10 days	[PMID: 29856759]
SK-NEP-1	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SK-NEP-1 cells after 10 days Antiproliferative activity against human SK-NEP-1 cells after 10 days	[PMID: 29856759]
SK-OV-3	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SK-OV-3 cells after 10 days Antiproliferative activity against human SK-OV-3 cells after 10 days	[PMID: 29856759]
SK-UT-1	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SK-UT-1 cells after 10 days Antiproliferative activity against human SK-UT-1 cells after 10 days	[PMID: 29856759]
SNB-19	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SNB-19 cells after 10 days Antiproliferative activity against human SNB-19 cells after 10 days	[PMID: 29856759]
SNU-16	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SNU-16 cells after 10 days Antiproliferative activity against human SNU-16 cells after 10 days	[PMID: 29856759]
SNU-423	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SNU-423 cells after 10 days Antiproliferative activity against human SNU-423 cells after 10 days	[PMID: 29856759]
SNU-5	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SNU-5 cells after 10 days Antiproliferative activity against human SNU-5 cells after 10 days	[PMID: 29856759]
SNU1	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SNU1 cells after 10 days Antiproliferative activity against human SNU1 cells after 10 days	[PMID: 29856759]
SR	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SR cells after 10 days Antiproliferative activity against human SR cells after 10 days	[PMID: 29856759]
ST486	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human ST486 cells after 10 days Antiproliferative activity against human ST486 cells after 10 days	[PMID: 29856759]
SU.86.86	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SU-86-86 cells after 10 days Antiproliferative activity against human SU-86-86 cells after 10 days	[PMID: 29856759]
SW 954	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW 954 cells after 10 days Antiproliferative activity against human SW 954 cells after 10 days	[PMID: 29856759]
SW 962	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW 962 cells after 10 days Antiproliferative activity against human SW 962 cells after 10 days	[PMID: 29856759]
SW-620	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW620 cells after 10 days Antiproliferative activity against human SW620 cells after 10 days	[PMID: 29856759]
SW1088	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW1088 cells after 10 days Antiproliferative activity against human SW1088 cells after 10 days	[PMID: 29856759]
SW13	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW13 cells after 10 days Antiproliferative activity against human SW13 cells after 10 days	[PMID: 29856759]
SW1353	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW1353 cells after 10 days Antiproliferative activity against human SW1353 cells after 10 days	[PMID: 29856759]
SW1417	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW1417 cells after 10 days Antiproliferative activity against human SW1417 cells after 10 days	[PMID: 29856759]
SW1463	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW1463 cells after 10 days Antiproliferative activity against human SW1463 cells after 10 days	[PMID: 29856759]
SW1783	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW1783 cells after 10 days Antiproliferative activity against human SW1783 cells after 10 days	[PMID: 29856759]
SW48	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW48 cells after 10 days Antiproliferative activity against human SW48 cells after 10 days	[PMID: 29856759]
SW480	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW480 cells after 10 days Antiproliferative activity against human SW480 cells after 10 days	[PMID: 29856759]
SW684	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW684 cells after 10 days Antiproliferative activity against human SW684 cells after 10 days	[PMID: 29856759]
SW837	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW837 cells after 10 days Antiproliferative activity against human SW837 cells after 10 days	[PMID: 29856759]
SW872	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW872 cells after 10 days Antiproliferative activity against human SW872 cells after 10 days	[PMID: 29856759]
SW900	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW900 cells after 10 days Antiproliferative activity against human SW900 cells after 10 days	[PMID: 29856759]
SW948	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW948 cells after 10 days Antiproliferative activity against human SW948 cells after 10 days	[PMID: 29856759]
SW982	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SW982 cells after 10 days Antiproliferative activity against human SW982 cells after 10 days	[PMID: 29856759]
SiHa	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human SiHa cells after 10 days Antiproliferative activity against human SiHa cells after 10 days	[PMID: 29856759]
T-24	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human T24 cells after 10 days Antiproliferative activity against human T24 cells after 10 days	[PMID: 29856759]
T47D	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human T47D cells after 10 days Antiproliferative activity against human T47D cells after 10 days	[PMID: 29856759]
T98G	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human T98G cells after 10 days Antiproliferative activity against human T98G cells after 10 days	[PMID: 29856759]
TCC-SUP	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human TCC-SUP cells after 10 days Antiproliferative activity against human TCC-SUP cells after 10 days	[PMID: 29856759]
THP-1	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human THP-1 cells after 10 days Antiproliferative activity against human THP-1 cells after 10 days	[PMID: 29856759]
U-266	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human U266B1 cells after 10 days Antiproliferative activity against human U266B1 cells after 10 days	[PMID: 29856759]
U-87MG ATCC	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human U-87MG cells after 10 days Antiproliferative activity against human U-87MG cells after 10 days	[PMID: 29856759]
U138-MG	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human U138-MG cells after 10 days Antiproliferative activity against human U138-MG cells after 10 days	[PMID: 29856759]
U2OS	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human U2OS cells after 10 days Antiproliferative activity against human U2OS cells after 10 days	[PMID: 29856759]
UMUC3	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human UM-UC-3 cells after 10 days Antiproliferative activity against human UM-UC-3 cells after 10 days	[PMID: 29856759]
WiDr	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human WiDr cells after 10 days Antiproliferative activity against human WiDr cells after 10 days	[PMID: 29856759]
Y79	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human Y79 cells after 10 days Antiproliferative activity against human Y79 cells after 10 days	[PMID: 29856759]
YAPC	IC₅₀	> 10 μM Compound: Chemical probe: EPZ032597	Antiproliferative activity against human YAPC cells after 10 days Antiproliferative activity against human YAPC cells after 10 days	[PMID: 29856759]

Molecular Weight

377.44

Formula

C₂₀H₂₃N₇O

CAS No.

1887193-58-9

SMILES

O=C(C1=CN(C2CC2)N=N1)NC3CN(C3)CC4=CN(CC5=CC=CC=C5)N=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Alshammari E, et al. Mechanistic and functional extrapolation of SET and MYND domain-containing protein 2 to pancreatic cancer. World J Gastroenterol. 2022 Aug 7;28(29):3753-3766. [Content Brief]

[2]. Thomenius MJ, et al. Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation. PLoS One. 2018 Jun 1;13(6):e0197372. [Content Brief]

EPZ032597 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EPZ0325971887193-58-9EPZ 032597EPZ-032597Histone MethyltransferaseSMYD2pancreatic ductal adenocarcinomaInhibitorinhibitorinhibit

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EPZ032597

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EPZ032597 Related Classifications

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