Azithromycin-d3
Based on 1 Customer Validation
Azithromycin-d3 is the deuterium labeled Azithromycin. Azithromycin (CP-62993) is a macrolide antibiotic useful for the treatment of a number of bacterial infections.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 163921-65-1
- Formula: C38H69D3N2O12
- Molecular Weight:752.00
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Antibiotic Isoforms
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Biological Activity
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Macrolide |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 163921-65-1
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Unlabeled Cas 83905-01-5
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Appearance Solid
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Molecular Weight 752.00
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Formula C38H69D3N2O12
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Color White to light yellow
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SMILES
C[C@H]([C@@H](O[C@@]([H])([C@@H]1O)O[C@@H](C[C@@H]1N(C)C)C)[C@](C[C@@H](C)CN2C([2H])([2H])[2H])(C)O)[C@H](O[C@@]([H])(C[C@]3(OC)C)O[C@H]([C@@H]3O)C)[C@@H](C)C(O[C@@H]([C@@](O)([C@@H]([C@H]2C)O)C)CC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
Ethanol : ≥ 100 mg/mL (132.98 mM)
DMSO : 100 mg/mL (132.98 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (283 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Menzel M, et al. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017 Mar 18. [Content Brief]
[3]. Vandooren J, et al. Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study. PLoS One. 2017 Apr 3;12(4):e0174853. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO | 1 mM | 1.3298 mL | 6.6489 mL | 13.2979 mL | 33.2447 mL |
| 5 mM | 0.2660 mL | 1.3298 mL | 2.6596 mL | 6.6489 mL | |
| 10 mM | 0.1330 mL | 0.6649 mL | 1.3298 mL | 3.3245 mL | |
| 15 mM | 0.0887 mL | 0.4433 mL | 0.8865 mL | 2.2163 mL | |
| 20 mM | 0.0665 mL | 0.3324 mL | 0.6649 mL | 1.6622 mL | |
| 25 mM | 0.0532 mL | 0.2660 mL | 0.5319 mL | 1.3298 mL | |
| 30 mM | 0.0443 mL | 0.2216 mL | 0.4433 mL | 1.1082 mL | |
| 40 mM | 0.0332 mL | 0.1662 mL | 0.3324 mL | 0.8311 mL | |
| 50 mM | 0.0266 mL | 0.1330 mL | 0.2660 mL | 0.6649 mL | |
| 60 mM | 0.0222 mL | 0.1108 mL | 0.2216 mL | 0.5541 mL | |
| 80 mM | 0.0166 mL | 0.0831 mL | 0.1662 mL | 0.4156 mL | |
| 100 mM | 0.0133 mL | 0.0665 mL | 0.1330 mL | 0.3324 mL |
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