Evifacotrep
Based on 1 Customer Validation
Evifacotrep, a short transient receptor potential channel 5 and 4 (TRPC5/TRPC4) antagonist (WO2020061162, compound 100), can be used for the research of neurological diseases. Evifacotrep targets to TRPC5/TRPC4 with IC50s ≤50 nM.
For research use only. We do not sell to patients.
- Purity: 99.65%
- CAS No.: 2413739-88-3
- Formula: C18H12ClF4N5O2
- Molecular Weight:441.77
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
TRPC5[1]
Evifacotrep (1 μM; 24 h) inhibits cell growth in ICLN-1694 cells(HEK-TRExhTRPC4)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2413739-88-3
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Appearance Solid
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Molecular Weight 441.77
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Formula C18H12ClF4N5O2
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Color White to off-white
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SMILES
O=C1NN=CC(N2CC3=C(CC2)C(OC4=CC=C(C=C4C(F)(F)F)F)=NC=N3)=C1Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (113.18 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. WO2020061162
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2636 mL | 11.3181 mL | 22.6362 mL | 56.5905 mL |
| 5 mM | 0.4527 mL | 2.2636 mL | 4.5272 mL | 11.3181 mL | |
| 10 mM | 0.2264 mL | 1.1318 mL | 2.2636 mL | 5.6591 mL | |
| 15 mM | 0.1509 mL | 0.7545 mL | 1.5091 mL | 3.7727 mL | |
| 20 mM | 0.1132 mL | 0.5659 mL | 1.1318 mL | 2.8295 mL | |
| 25 mM | 0.0905 mL | 0.4527 mL | 0.9054 mL | 2.2636 mL | |
| 30 mM | 0.0755 mL | 0.3773 mL | 0.7545 mL | 1.8864 mL | |
| 40 mM | 0.0566 mL | 0.2830 mL | 0.5659 mL | 1.4148 mL | |
| 50 mM | 0.0453 mL | 0.2264 mL | 0.4527 mL | 1.1318 mL | |
| 60 mM | 0.0377 mL | 0.1886 mL | 0.3773 mL | 0.9432 mL | |
| 80 mM | 0.0283 mL | 0.1415 mL | 0.2830 mL | 0.7074 mL | |
| 100 mM | 0.0226 mL | 0.1132 mL | 0.2264 mL | 0.5659 mL |
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