2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. Evifacotrep

Evifacotrep, a short transient receptor potential channel 5 and 4 (TRPC5/TRPC4) antagonist (WO2020061162, compound 100), can be used for the research of neurological diseases. Evifacotrep targets to TRPC5/TRPC4 with IC50s ≤50 nM.

For research use only. We do not sell to patients.

Evifacotrep Chemical Structure

Evifacotrep Chemical Structure

CAS No. : 2413739-88-3

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10 mM * 1 mL in DMSO
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Customer Review

Based on 1 publication(s) in Google Scholar

Evifacotrep Related Antibodies

Top Publications Citing Use of Products

View All TRP Channel Isoform Specific Products:

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TRPC TRPM TRPV TRPA TRPML

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Evifacotrep, a short transient receptor potential channel 5 and 4 (TRPC5/TRPC4) antagonist (WO2020061162, compound 100), can be used for the research of neurological diseases. Evifacotrep targets to TRPC5/TRPC4 with IC50s ≤50 nM[1].

IC50 & Target

TRPC5[1]
In Vitro

Evifacotrep (1 μM; 24 h) inhibits cell growth in ICLN-1694 cells(HEK-TRExhTRPC4)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Evifacotrep Related Antibodies
In Vivo

Evifacotrep (30 mg/kg; sc; once daily or twice daily for 10 days) results in reduced urinary albumin excretion on following injury with puromycinaminonucleoside (PAN)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

441.77

Formula

C18H12ClF4N5O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NN=CC(N2CC3=C(CC2)C(OC4=CC=C(C=C4C(F)(F)F)F)=NC=N3)=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (113.18 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2636 mL 11.3181 mL 22.6362 mL
5 mM 0.4527 mL 2.2636 mL 4.5272 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2636 mL 11.3181 mL 22.6362 mL 56.5905 mL
5 mM 0.4527 mL 2.2636 mL 4.5272 mL 11.3181 mL
10 mM 0.2264 mL 1.1318 mL 2.2636 mL 5.6591 mL
15 mM 0.1509 mL 0.7545 mL 1.5091 mL 3.7727 mL
20 mM 0.1132 mL 0.5659 mL 1.1318 mL 2.8295 mL
25 mM 0.0905 mL 0.4527 mL 0.9054 mL 2.2636 mL
30 mM 0.0755 mL 0.3773 mL 0.7545 mL 1.8864 mL
40 mM 0.0566 mL 0.2830 mL 0.5659 mL 1.4148 mL
50 mM 0.0453 mL 0.2264 mL 0.4527 mL 1.1318 mL
60 mM 0.0377 mL 0.1886 mL 0.3773 mL 0.9432 mL
80 mM 0.0283 mL 0.1415 mL 0.2830 mL 0.7074 mL
100 mM 0.0226 mL 0.1132 mL 0.2264 mL 0.5659 mL
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Evifacotrep Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Evifacotrep2413739-88-3TRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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