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INSIG2 - insulin induced gene 2 Gene

Also Known as INSIG-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51141

About INSIG2

Cytogenetic location: 2q14.1-q14.2 Genomic coordinates (GRCh38): 2:118,088,471-118,110,997 (from NCBI)

This gene has 7 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in liver (RPKM 12.3), lung (RPKM 10.5) and 25 other tissues.

Summary

The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008]

INSIG2 Products (6)

mRNA	Protein	Name
NM_001321329.2	NP_001308258.1	insulin-induced gene 2 protein isoform a
NM_001321330.2	NP_001308259.1	insulin-induced gene 2 protein isoform b
NM_001321331.2	NP_001308260.1	insulin-induced gene 2 protein isoform b
NM_001321332.2	NP_001308261.1	insulin-induced gene 2 protein isoform b
NM_001321333.2	NP_001308262.1	insulin-induced gene 2 protein isoform c
NM_016133.4	NP_057217.2	insulin-induced gene 2 protein isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables oxysterol binding	IDA IDA: Inferred from direct assay	17428920	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12242332	GOA
enables protein sequestering activity	IDA IDA: Inferred from direct assay	15899885	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in SREBP signaling pathway	IDA IDA: Inferred from direct assay	12242332	GOA
involved in SREBP-SCAP complex retention in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15899885	GOA
involved in cholesterol biosynthetic process	IDA IDA: Inferred from direct assay	32322062	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of SREBP-SCAP-Insig complex	IDA IDA: Inferred from direct assay	12242332	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	32322062	GOA
is active in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	32322062	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INSIG2 Protein Structure

INSIG

0
100
200
225 a.a.

Protein Preferred Names	Protein Names
insulin-induced gene 2 protein	INSIG2 membrane protein

INSIG2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	INSIG2	Q9Y5U4	VMA21	Homo sapiens	Q3ZAQ7	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	VMA21	Homo sapiens	Q3ZAQ7	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	NEMP1	Homo sapiens	O14524-2	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	NEMP1	Homo sapiens	O14524-2	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	AQP2	Homo sapiens	P41181	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	AQP2	Homo sapiens	P41181	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	SLC16A10	Homo sapiens	Q8TF71	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	SLC16A10	Homo sapiens	Q8TF71	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	TMEM52B	Homo sapiens	Q4KMG9	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	TMEM52B	Homo sapiens	Q4KMG9	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	CYBC1	Homo sapiens	Q9BQA9	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	CYBC1	Homo sapiens	Q9BQA9	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	LAPTM5	Homo sapiens	Q13571	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	LAPTM5	Homo sapiens	Q13571	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	GPR37L1	Homo sapiens	O60883	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	GPR37L1	Homo sapiens	O60883	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	RNF5	Homo sapiens	Q99942	Validated Y2H	25416956
Intra	INSIG2	Q9Y5U4	RNF5	Homo sapiens	Q99942	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	RNF5	Homo sapiens	Q99942	Y2H Prey Pooling	25416956
Intra	INSIG2	Q9Y5U4	RNF5	Homo sapiens	Q99942	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	ATP6V0B	Homo sapiens	Q99437	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	ATP6V0B	Homo sapiens	Q99437	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	IFNGR2	Homo sapiens	P38484	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	IFNGR2	Homo sapiens	P38484	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	PVR	Homo sapiens	P15151	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	PVR	Homo sapiens	P15151	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	TMEM45B	Homo sapiens	Q96B21	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	TMEM45B	Homo sapiens	Q96B21	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	STIM1	Homo sapiens	Q13586	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	STIM1	Homo sapiens	Q13586	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	PRLR	Homo sapiens	P16471	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	PRLR	Homo sapiens	P16471	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	CD40	Homo sapiens	P25942	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	CD40	Homo sapiens	P25942	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	MMGT1	Homo sapiens	Q8N4V1	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	MMGT1	Homo sapiens	Q8N4V1	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	GOLM1	Homo sapiens	Q8NBJ4	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	ABHD4	Homo sapiens	Q8TB40	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	ABHD4	Homo sapiens	Q8TB40	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	KIR2DL3	Homo sapiens	P43628	Y2H Array	32296183
Intra	INSIG2	Q9Y5U4	KIR2DL3	Homo sapiens	P43628	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	INSIG2	Q9Y5U4	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Leptin Deficiency Or Dysfunction	Morbid Obesity Obesity Due To Congenital Leptin Deficiency LEPD Congenital Leptin Deficiency Obesity, Morbid Obesity, Morbid, Due To Leptin Deficiency Severe Obesity Obesity, Morbid, Nonsyndromic 1 Leptin Deficiency Obesity, Severe, Due To Leptin Deficiency Leptin Morbid Obesity Due To Leptin Deficiency Obesity Morbid Leptin Dysfunction
Diabetes Mellitus	Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-N20666	Canola oil		/	Unkown
HY-RS06838	INSIG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	INSIG2	VGNC	VGNC:73632
Bos taurus	INSIG2	VGNC	VGNC:30218
Rattus norvegicus	INSIG2	RGD	RGD:631417
Canis familiaris	INSIG2	VGNC	VGNC:42040
Mus musculus	INSIG2	MGD	MGI:1920249
Felis catus	INSIG2	VGNC	VGNC:62933
Others	INSIG2	NCBI