Hericene A
Based on 1 Customer Validation
Hericene A is an orally active aromatic hericene derivative. Hericene A exhibits anti-inflammatory and neurotrophic activities, and can found in the fruiting bodies of Hericium erinaceus. Hericene A inhibits the secretion of pro-inflammatory mediators. Hericene A promotes axonal growth, neurite branching, neurotrophic factor expression and downstream signal transduction. Hericene A can be used for the research of inflammatory and neurological diseases.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.84%
- CAS No.: 157207-54-0
- Formule: C35H56O5
- Masse moléculaire:556.82
-
Stockage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
-
Immunology/Inflammation Compound Library
HY-L007
-
MAPK Compound Library
HY-L010
-
Neuronal Signaling Compound Library
HY-L013
-
Protein Tyrosine Kinase Compound Library
HY-L016
-
Stem Cell Signaling Compound Library
HY-L017
-
Natural Product Library
HY-L021
-
Anti-Aging Compound Library
HY-L034
-
Differentiation Inducing Compound Library
HY-L038
-
Oxygen Sensing Compound Library
HY-L045
-
Phenols Library
HY-L057
-
Orally Active Compound Library
HY-L061
-
Glutamine Metabolism Compound Library
HY-L064
-
Angiogenesis-Related Compound Library
HY-L088
-
Plant-Sourced Natural Product Library
HY-L115
-
Pain-Related Compound Library
HY-L139
-
Membrane Protein-targeted Compound Library
HY-L149
-
Membrane Receptor-targeted Compound Library
HY-L150
-
Cytokine Inhibitors Library
HY-L161
-
Multi-Target Compound Library
HY-L176
-
Radioprotector Library
HY-L178
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Natural Product Library Plus
HY-L021P
-
Natural Product and Natural Product-Like Compound Library
HY-L021M
-
Bioactive Compound Library
HY-L001
-
Protein Kinase Compound Library
HY-L196
-
Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
-
Cell Proliferation Compound Library
HY-L201
-
High-Throughput Bioactive Compound Library
HY-L205
-
High-Throughput Natural Product Library
HY-L206
-
Anti-Rheumatic Arthritis Compound Library
HY-L210
-
Lactylation Compound Library
HY-L249
-
Mass Spectrometry Natural Product Library
HY-L262
Activité biologique
|
IL-6 |
Hericene A (0.5-100 μM; 2 h pretreatment) inhibits LPS (HY-D1056)-induced secretion of TNF-α, IL-6 and NO in mouse RAW 264.7 macrophages, with IC50 values of 78.50 µM, 56.33 µM and 87.31 µM, respectively, and does not reduce cell viability at the tested concentrations[1].
Hericene A (10 μg/mL; 24 h) potently promotes axonal growth in primary hippocampal neurons isolated from E18 Sprague Dawley rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:RAW 264.7 macrophage cells treated LPS
-
Concentration:0.5, 1, 5, 10, 50, 100 μM
-
Incubation Time:2 h pretreatment + 24 h LPS stimulation
-
Result:Inhibited IL-6 and NO production in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:ICR mice (male, 6 weeks old, 23-25 g)[2]
-
Dosage:5 mg/kg
-
Administration:p.o.; daily; 31 days
-
Result:Increased brain levels of neurotrophins BDNF, NGF, CNTF, and GDNF.
Increased phosphorylation of neurotrophin receptors TrkB and TrkA.
Increased activation of downstream signaling molecules ERK1/2 and CREB.
Increased levels of synaptophysin (SYP), a synaptic marker.
Increased BDNF immunoreactivity in the dentate gyrus of the hippocampus and cortical regions.
Significantly enhanced novel object recognition performance.
Significantly enhanced spontaneous alternation behavior in the Y-maze test.
Chemical Information
-
CAS No. 157207-54-0
-
Appearance Solid
-
Masse moléculaire 556.82
-
Formule C35H56O5
-
Color White to off-white
-
SMILES
CCCCCCCCCCCCCCCC(OCC1=C(C(O)=C(C(OC)=C1)C/C=C(C)/CC/C=C(C)\C)C=O)=O
-
Structure Classification
-
Initial Source
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Pureté et documentation
-
Fiche technique (267 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instruction de manipulation (2659 KB)
Références
[1]. Xie G, et al. Secondary Metabolites from Hericium erinaceus and Their Anti-Inflammatory Activities. Molecules. 2022 Mar 27;27(7):2157. [Content Brief]
[2]. Martínez-Mármol R, et al. Hericerin derivatives activates a pan-neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory. J Neurochem. 2023;165(6):791-808. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hericene A Related Classifications
HY-N16499 Related Classifications
Powered by Bioz