Cyclam
Based on 1 publication(s) in Google Scholar
Cyclam is a metal chelator that forms metal complexes with a variety of metal ions. Cyclam metal complexes exhibits anti-HIV (such as AMD3100), nitric oxide (NO) releasing and scavenging (such as Zn(II)-Cyclam and Ru(II)-Cyclam), and SOD mimetic (such as Mn(III)-Cyclam and Zn(II)-Cyclam) activities.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 295-37-4
- Formula: C10H24N4
- Molecular Weight:200.33
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Cyclam
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>50 μM
Compound: Cyclam
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Cytotoxicity against human A549 cells incubated for 24 hrs by sulforhodamine B assay
Cytotoxicity against human A549 cells incubated for 24 hrs by sulforhodamine B assay
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[PMID: 26211460] |
| HCT-116 | IC50 |
>50 μM
Compound: Cyclam
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Cytotoxicity against human HCT116 cells incubated for 24 hrs by sulforhodamine B assay
Cytotoxicity against human HCT116 cells incubated for 24 hrs by sulforhodamine B assay
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[PMID: 26211460] |
| HeLa | IC50 |
>50 μM
Compound: Cyclam
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Cytotoxicity against human HeLa cells incubated for 24 hrs by sulforhodamine B assay
Cytotoxicity against human HeLa cells incubated for 24 hrs by sulforhodamine B assay
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[PMID: 26211460] |
| MT4 | CC50 |
>1248 μM
Compound: 42
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Concentration required to reduce the viability of mock-infected MT-4 cells
Concentration required to reduce the viability of mock-infected MT-4 cells
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[PMID: 7830280] |
| MT4 | EC50 |
150 μM
Compound: 42
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Concentration required to protect the virus infected cells against viral cytopathicity was measured on HIV-2(ROD) virus strain in MT-4 cells
Concentration required to protect the virus infected cells against viral cytopathicity was measured on HIV-2(ROD) virus strain in MT-4 cells
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[PMID: 7830280] |
| MT4 | EC50 |
399 μM
Compound: 42
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Concentration required to protect the virus infected cells against viral cytopathicity was measured on HIV-1(IIIB) virus strain in MT-4 cells
Concentration required to protect the virus infected cells against viral cytopathicity was measured on HIV-1(IIIB) virus strain in MT-4 cells
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[PMID: 7830280] |
Chemical Information
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CAS No. 295-37-4
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Appearance Solid
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Molecular Weight 200.33
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Formula C10H24N4
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Color White to yellow
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SMILES
N1CCNCCCNCCNCCC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
H2O : 20 mg/mL (99.84 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.9918 mL | 24.9588 mL | 49.9176 mL | 124.7941 mL |
| 5 mM | 0.9984 mL | 4.9918 mL | 9.9835 mL | 24.9588 mL | |
| 10 mM | 0.4992 mL | 2.4959 mL | 4.9918 mL | 12.4794 mL | |
| 15 mM | 0.3328 mL | 1.6639 mL | 3.3278 mL | 8.3196 mL | |
| 20 mM | 0.2496 mL | 1.2479 mL | 2.4959 mL | 6.2397 mL | |
| 25 mM | 0.1997 mL | 0.9984 mL | 1.9967 mL | 4.9918 mL | |
| 30 mM | 0.1664 mL | 0.8320 mL | 1.6639 mL | 4.1598 mL | |
| 40 mM | 0.1248 mL | 0.6240 mL | 1.2479 mL | 3.1199 mL | |
| 50 mM | 0.0998 mL | 0.4992 mL | 0.9984 mL | 2.4959 mL | |
| 60 mM | 0.0832 mL | 0.4160 mL | 0.8320 mL | 2.0799 mL | |
| 80 mM | 0.0624 mL | 0.3120 mL | 0.6240 mL | 1.5599 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Cyclam Related Classifications
HY-D0179 Related Classifications
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