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Referencia número: HY-183653

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AK442

AK442 is a selective PRMT4 (CARM1) inhibitor with an IC₅₀ of 2.6 nM against human targets. AK442 is applicable to breast cancer-related research.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 3062376-05-7
Fòrmula: C₃₅H₄₀ClN₉O₄
Peso molecular:686.20

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

AK442 Chemical Structure

No. CAS: 3062376-05-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- IC₅₀ & Target
- In Vitro
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Actividad biológica

Descripciòn

AK442 is a selective PRMT4 (CARM1) inhibitor with an IC₅₀ of 2.6 nM against human targets. AK442 is applicable to breast cancer-related research^[1].

IC₅₀ & Target^[1]

PRMT4

Ver todos los productos específicos de isoformas Histone Methyltransferase :

In Vitro

AK442 (10 μM; 6.5 h) binds to PRMT4 in MDA-MB-231 cells and increases the thermal stability of PRMT4 by 2 °C compared with the DMSO control group^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 3062376-05-7
Peso molecular 686.20
Fòrmula C₃₅H₄₀ClN₉O₄
SMILES

O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1CN(CCNCC4=CC(C5=CC=C(C=C5)Cl)=CC=C4)CCNC(NCC6=CC=CC=C6)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Kulkarni AS, et al. Tailoring PRMT Inhibition: Shifting PRMT7 Selectivity to PRMT4 through "T-Shape" Strategy and "Linker-Specific" Preferences. J Med Chem. 2026 May 14;69(9):9977-9990. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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- In Vitro
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AK442

Ver todos los productos específicos de isoformas Histone Methyltransferase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

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AK442 Related Classifications

HY-183653 Related Classifications