Anticancer agent 71
Anticancer agent 71 (Compound 4b) is a potent anticancer agent and induces apoptosis. Anticancer agent 71 arrests cell cycle at G2/M phase and induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression levels. Anticancer agent 71 shows antiproliferative activity.
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- No. CAS: 2453228-45-8
- Fòrmula: C18H13ClF3N5O
- Peso molecular:407.78
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Almacenamiento:
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Actividad biológica
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Chemical Information
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Actividad biológica
Anticancer agent 71 (Compound 4b) (0.1-50 μM, 24 hours; SW480 and PC3 cells) increases the cytotoxicity and exerts potent antitumor activities against SW480 and PC3 cells[1].
Anticancer agent 71 (Compound 4b) (11.08 μM, 24 hours; SW480 cells) induces a significant G2/M phase arrest[1].
Anticancer agent 71 (Compound 4b) (11.08 μM, 24 hours) induces apoptosis in SW480 cells by upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SW480 and PC3 cells
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Concentration:0.1, 1, 12.5, 25 and 50 μM
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Incubation Time:24 hours
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Result:Inhibited with IC50 values of 11.08 and 17.39 μM for SW480 and PC3 cells, respectively.
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Cell Line:SW480 cells
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Concentration:11.08 μM
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Incubation Time:24 hours
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Result:The cell population percent at G2/M phase increased to 45.3%.
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Cell Line:SW480 cells
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Concentration:11.08 μM
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Incubation Time:24 hours
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Result:The percentage of cells in early and late apoptosis was recorded as 5.69% and 3.52%, respectively.
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Cell Line:SW480 cells
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Concentration:11.08 μM
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Incubation Time:24 hours
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Result:The expression of antiapoptotic protein Bcl-2 decreased and the expression of Pro apoptotic Bax increased.
Chemical Information
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No. CAS 2453228-45-8
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Peso molecular 407.78
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Fòrmula C18H13ClF3N5O
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SMILES
NC1=NC(NC(NC2=CC=C(C(C(F)(F)F)=C2)Cl)=O)=CC(C3=CC=CC=C3)=N1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 71 Related Classifications
HY-147906 Related Classifications
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