CDK2-IN-28
CDK2-IN-28 (compound 22) is a CDK2 inhibitor with good selectivity and cellular effects against other CDKs. CDK2-IN-28 has anti-proliferative effects on MKN1 cells (EC50: 0.31 μM).
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- No. CAS: 3025006-64-5
- Fòrmula: C25H35N7O3S
- Peso molecular:513.66
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Actividad biológica
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CDK7 54.7 nM (Ki, [1]) |
CDK2 1 nM (Ki, [1]) |
CDK5 15.8 nM (Ki, [1]) |
CDK9 12.8 nM (Ki, [1]) |
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Cell Line
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Type | Value | Description | References |
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| MKN-1 | EC50 |
0.31 μM
Compound: 22
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Antiproliferative activity against human MKN-1 cells incubated for 5 days by CCK-8 assay
Antiproliferative activity against human MKN-1 cells incubated for 5 days by CCK-8 assay
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[PMID: 38583237] |
CDK2-IN-28 (37 nM-3 μM; 24 h) significantly down-regulates the level of Rb phosphorylation at Ser807/811 and Ser780 in MKN1 cells[1].
CDK2-IN-28 (333.3 nM; 24 h) CDK2 inhibition in MKN1 cells causes cell cycle arrest in the G2/M phase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MKN1 cells
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Concentration:37 nM, 111.1 nM, 333.3 nM, 1000 nM, 3000 nM
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Incubation Time:24 h
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Result:Significantly downregulated Rb phosphorylation at Ser807/811 and Ser780 in dose dependent way.
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Cell Line:MKN1 cells
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Concentration:111.1 nM and 333.3 nM
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Incubation Time:24 h
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Result:Caused by CDK2 inhibition is accumulation of G0/G1 cells as the CDK2/cyclin E-mediated phosphorylation of Rb relieves suppression of the E2Fs, thus allowing G1/S transition through the restriction point.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 3025006-64-5
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Peso molecular 513.66
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Fòrmula C25H35N7O3S
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SMILES
CS(C1=CC=C(CN2)C(OCCCCCN(CC3CNC3)C4=NC5=C(C(C)C)C=NN5C2=N4)=C1)(=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDK2-IN-28 Related Classifications
HY-161463 Related Classifications
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