Ceftolozane
Based on 2 publication(s) in Google Scholar
Ceftolozane (CXA-101 free base; FR264205 free base) is a cephalosporin antibiotic with potent activity againstPseudomonas aeruginosa and strains Enterobacteriaceae, with MICs of 0.5 and 0.25-0.5 mg/L.
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- No. CAS: 689293-68-3
- Fòrmula: C23H30N12O8S2
- Peso molecular:666.69
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ceftolozane
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Actividad biológica
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 689293-68-3
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Appearance Solid
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Peso molecular 666.69
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Fòrmula C23H30N12O8S2
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Color White to off-white
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SMILES
CN1[N+](CC(CS[C@]2([H])[C@@H]3NC(/C(C4=NSC(N)=N4)=N\OC(C)(C(O)=O)C)=O)=C(C([O-])=O)N2C3=O)=CC(NC(NCCN)=O)=C1N
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Synonyms
CXA-101 free base; FR264205 free base
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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PLoS Pathog
Differential contribution of PBP occupancy and efflux on the effectiveness of β-lactams at their target site in clinical isolates of Neisseria gonorrhoeae. [Abstract]2024 Dec 31;20(12):e1012783. PMID: 39739989 -
Microbiol Spectr
Penicillin-Binding Protein Occupancy Dataset for 18 β-Lactams and 4 β-Lactamase Inhibitors in Neisseria gonorrhoeae. [Abstract]2023 Jun 15;11(3):e0069223. PMID: 37093051
Solvente y solubilidad
DMSO : 24 mg/mL (36.00 mM; ultrasonic and adjust pH to 2 with HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Craig WA, et al., In vivo activities of ceftolozane, a new cephalosporin, with and without tazobactam against Pseudomonas aeruginosa and Enterobacteriaceae, including strains with extended-spectrum β-lactamases, in the thighs of neutropenic mice. Antimicrob Agents Chemother. 2013 Apr;57(4):1577-82. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4999 mL | 7.4997 mL | 14.9995 mL | 37.4987 mL |
| 5 mM | 0.3000 mL | 1.4999 mL | 2.9999 mL | 7.4997 mL | |
| 10 mM | 0.1500 mL | 0.7500 mL | 1.4999 mL | 3.7499 mL | |
| 15 mM | 0.1000 mL | 0.5000 mL | 1.0000 mL | 2.4999 mL | |
| 20 mM | 0.0750 mL | 0.3750 mL | 0.7500 mL | 1.8749 mL | |
| 25 mM | 0.0600 mL | 0.3000 mL | 0.6000 mL | 1.4999 mL | |
| 30 mM | 0.0500 mL | 0.2500 mL | 0.5000 mL | 1.2500 mL |
Ceftolozane Related Classifications
HY-19806 Related Classifications
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