Cymarin
Based on 1 Customer Validation
Cymarin, a cardiac glycoside, potently inhibits the Palytoxin (PTX)-induced K+ release (IC50=0.42 μM). Cymarin reveals an antitumor activity against breast cancer and pancreatic cancer. Cymarin exhibits antifeedant and growth inhibitory effects as crop protectant.
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- Pureza: 97.28%
- No. CAS: 508-77-0
- Fòrmula: C30H44O9
- Peso molecular:548.66
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Panel NCI-60 (60 carcinoma cell lines) | GI50 |
39 nM
Compound: Cymarin
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Growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program
Growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program
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[PMID: 15743190] |
In Vitro
Cymarin (0.25-1 μM) inhibites PAX6 expression by blocking IRES-directed translation and inhibits 47.8% proliferation of MCF-7 cells with the concentration of 1 μM [2].
Cymarin downregulates UGT1A10 expression, eliminates TRA-1-60 (IC50 of 15.2 nM) and TRA-1-81 cells (IC50 of 5.1 nM) in cell lines SW1990GR, inhibits proliferations and cell viabilities of pancreatic cancer cells SW1990 and SW1990GR (IC50 of 33.8 nM for SW1990 and 40.8 nM for SW1990GR)[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SW1990 and SW1990GR
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Concentration:0-500 nM
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Incubation Time:72 h
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Result:Decreased cell viability with IC50 of 33.8 nM for SW1990 and 40.8 for SW1990GR.
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Cell Line:MCF-7
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Concentration:0.25-1 μM
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Incubation Time:5 days
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Result:Inhibits proliferation of MCF-7 cells in a dose-dependent manner.
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Cell Line:MCF-7
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Concentration:0.25-1 μM
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Incubation Time:24 h
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Result:Downregulated levels of PAX6.
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Cell Line:SW1990 and SW1990GR
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Concentration:7-15 μM
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Incubation Time:
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Result:Decreased levels of UGT1A10 transcription.
In Vivo
Cymarin (2 mg/kg, i.p., twice a week for 3 weeks) inhibits tumor growth, eliminates TRA-1-60 cells and decreases chemoresistance in SW1990 xenografted nude mice[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Trichoplusia ni[3]
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Dosage:1000 p.p.m.
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Administration:p.o. for 10 days
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Result:Inhibited growth and revealed a feeding deterrent to T.ni.
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Animal Model:Luciferase labeled SW1990 xenograft in nude mice[4]
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Dosage:2 mg/kg
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Administration:i.p., twice a week for 3 weeks
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Result:Inhibited tumor growth.
Chemical Information
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No. CAS 508-77-0
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Appearance Solid
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Peso molecular 548.66
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Fòrmula C30H44O9
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Color White to off-white
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SMILES
O=C[C@@]12[C@]3([H])[C@](CC[C@@]1(C[C@@H](O[C@@]4([H])C[C@@H]([C@H](O)[C@@H](C)O4)OC)CC2)O)([H])[C@@]5([C@@](C)([C@@H](C(CO6)=CC6=O)CC5)CC3)O
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (278 KB)
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SDS (644 KB)
- English - EN (644 KB)
- Français - FR (644 KB)
- Deutsch - DE (644 KB)
- Norwegian - NO (644 KB)
- Español - ES (644 KB)
- Swedish - SV (644 KB)
- Italian - IT (644 KB)
- Korean - KR (644 KB)
- Portuguese - PT (644 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Ozaki H, et al. Interaction of palytoxin and cardiac glycosides on erythrocyte membrane and (Na+ + K+) ATPase. Eur J Biochem. 1985;152(2):475-480. [Content Brief]
[2]. Li Q, et al., Translation of paired box 6 (PAX6) mRNA is IRES-mediated and inhibited by cymarin in breast cancer cells. Genes Genet Syst. 2023 Oct 24;98(4):161-169. [Content Brief]
[4]. Tan L, et al., A targetable pathway to eliminate TRA-1-60+/TRA-1-81+ chemoresistant cancer cells. J Mol Cell Biol. 2023 Nov 27;15(6):mjad039. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cymarin Related Classifications
HY-111934 Related Classifications
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