Echinomycin
Based on 12 publication(s) in Google Scholar
Echinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC50 of 29.4 pM.
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- Pureza: 98.57%
- No. CAS: 512-64-1
- Fòrmula: C51H64N12O12S2
- Peso molecular:1101.26
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Almacenamiento:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Echinomycin
More- Theranostics. 2025 Mar 21;15(10):4593-4613. [Abstract]
- Theranostics. 2022 Apr 4;12(7):3196-3216. [Abstract]
- Theranostics. 2022 Jan 16;12(4):1621-1638. [Abstract]
- Blood Adv. 2025 Nov 5:bloodadvances.2025016344. [Abstract]
- Sci Signal. 2023 Dec 5;16(814):eadd2282. [Abstract]
- Commun Biol. 2026 Mar 19. [Abstract]
- Cell Signal. 2026 Oct:146:112697. [Abstract]
- Oncol Rep. 2023 Dec;50(6):219. [Abstract]
- Diabetes Metab Syndr Obes. 2025 Nov 14:18:4211-4227. [Abstract]
- J Cardiovasc Dev Dis. 2025 Nov 6;12(11):438. [Abstract]
- bioRxiv. 2024 Nov 06.
- University of Sheffield. 2024 Nov 05.
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16 | IC50 |
0.4 μg/mL
Compound: Echinomycin
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Inhibitory activity against growth of B16 mouse myeloma cell line was determined by MTT assay
Inhibitory activity against growth of B16 mouse myeloma cell line was determined by MTT assay
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[PMID: 14698199] |
| BeWo | IC50 |
1 μg/mL
Compound: Echinomycin
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Inhibitory activity against growth of BeWO placental tumor cell line was determined by MTT assay
Inhibitory activity against growth of BeWO placental tumor cell line was determined by MTT assay
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[PMID: 14698199] |
| CCRF-CEM | IC50 |
0.5 μM
Compound: Echinomycin
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Cytotoxicity in human leukemic CCRF-CEM cells.
Cytotoxicity in human leukemic CCRF-CEM cells.
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[PMID: 14667232] |
| HCT-116 | IC50 |
<0.003 μM
Compound: 1
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Cytotoxicity against human HCT116 cells
Cytotoxicity against human HCT116 cells
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[PMID: 19185486] |
| HT-29 | IC50 |
2.2 μg/mL
Compound: Echinomycin
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Inhibitory activity against growth of HT-29 colon tumor cell line was determined by MTT assay
Inhibitory activity against growth of HT-29 colon tumor cell line was determined by MTT assay
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[PMID: 14698199] |
| Huh-7 | CC50 |
>10 μM
Compound: GNF-Pf-1958
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NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
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[PMID: 18579783] |
| PANC-1 | IC50 |
1.8 μg/mL
Compound: Echinomycin
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Inhibitory activity against growth of PANC-1 tumor cell line was determined by MTT assay
Inhibitory activity against growth of PANC-1 tumor cell line was determined by MTT assay
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[PMID: 14698199] |
| U-251 | EC50 |
1.2 nM
Compound: 19, NSC-13502
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Binding affinity to HIF-1 5'-CGTG-3' DNA sequence in human U251 cells assessed as inhibition of HRE-mediated reporter activation
Binding affinity to HIF-1 5'-CGTG-3' DNA sequence in human U251 cells assessed as inhibition of HRE-mediated reporter activation
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[PMID: 22305612] |
Echinomycin (0-10 nM; 16 hours; U251 cells) treatment significantly inhibits hypoxia-induced VEGF mRNA expression in a dose-dependent fashion. Echinomycin very potently inhibits hypoxic induction of luciferase expression in U251-HRE in a dose-dependent fashion with an EC50 of 1.2 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U251 cells
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Concentration:0 nM, 0.625 nM, 1.25 nM, 5 nM, 10 nM
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Incubation Time:16 hours
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Result:Significantly inhibited VEGF mRNA expression induced by hypoxia in a dose-dependent fashion.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NOD-SCID mice received 1.8Gy of irradiation and i.v. injection with peripheral blood cells from patients AML-71 and AML-150[2]
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Dosage:10 μg/kg
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Administration:Intravenous injection; for 40 days
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Result:Efficiently eradicated mouse lymphoma and serially transplantable human AML in xenogeneic model by preferential elimination of CSCs.
Chemical Information
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No. CAS 512-64-1
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Appearance Solid
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Peso molecular 1101.26
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Fòrmula C51H64N12O12S2
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Color White to off-white
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SMILES
[H]C1=NC2=C(N=C1C(N[C@H](COC([C@H](C(C)C)N(C)C([C@H]3N4C)=O)=O)C(N[C@@H](C)C(N(C)[C@@H]([C@@H](SC)SC3)C(N(C)[C@@H](C(C)C)C(OC[C@@H](NC(C5=NC6=C(C=CC=C6)N=C5[H])=O)C(N[C@@H](C)C4=O)=O)=O)=O)=O)=O)=O)C=CC=C2
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Synonyms
Quinomycin A; NSC-13502
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (12)
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Journal Impact Factor
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Most Recent
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Theranostics
FOS-driven inflammatory CAFs promote colorectal cancer liver metastasis via the SFRP1-FGFR2-HIF1 axis. [Abstract]2025 Mar 21;15(10):4593-4613. PMID: 40225580 -
Theranostics
Neuronal STAT3/HIF-1α/PTRF axis-mediated bioenergetic disturbance exacerbates cerebral ischemia-reperfusion injury via PLA2G4A. [Abstract]2022 Apr 4;12(7):3196-3216. PMID: 35547748 -
Theranostics
Piezo1-mediated mechanosensation in bone marrow macrophages promotes vascular niche regeneration after irradiation injury. [Abstract]2022 Jan 16;12(4):1621-1638. PMID: 35198061 -
Blood Adv
Hypoxia-inducible Factors Contribute to Venous Thrombosis in a Mouse Model of Myeloproliferative Neoplasms. [Abstract]2025 Nov 5:bloodadvances.2025016344. PMID: 41191539 -
Sci Signal
STAT3 palmitoylation initiates a positive feedback loop that promotes the malignancy of hepatocellular carcinoma cells in mice. [Abstract]2023 Dec 5;16(814):eadd2282. PMID: 38051779 -
Commun Biol
2026 Mar 19. PMID: 41857306 -
Cell Signal
Pan-cancer analysis reveals the prognostic relevance of NUP54 and its association with HIF-1α-related glycolytic phenotypes in lung adenocarcinoma. [Abstract]2026 Oct:146:112697. PMID: 42349706 -
Oncol Rep
P53‑microRNA interactions regulate the response of colorectal tumor cells to oxaliplatin under normoxic and hypoxic conditions. [Abstract]2023 Dec;50(6):219. PMID: 37921068 -
Diabetes Metab Syndr Obes
PEDF Alleviates Diabetic Renal Fibrosis by Degrading Kidney Ectopic Fat Deposition and Inhibiting Metabolic Reprogramming of Renal Tubular Epithelial Cells. [Abstract]2025 Nov 14:18:4211-4227. PMID: 41262465 -
J Cardiovasc Dev Dis
Role of P2X7 Receptor on Hypoxia-Induced Vascular Endothelial Growth Factor Gene Expression in H9c2 Rat Cardiomyocytes. [Abstract]2025 Nov 6;12(11):438. PMID: 41295364 -
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Solvente y solubilidad
DMSO : 5.3 mg/mL (4.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (645 KB)
- English - EN (645 KB)
- Français - FR (645 KB)
- Deutsch - DE (645 KB)
- Norwegian - NO (645 KB)
- Español - ES (645 KB)
- Swedish - SV (645 KB)
- Italian - IT (645 KB)
- Korean - KR (645 KB)
- Portuguese - PT (645 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Kong D, et al. Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res. 2005 Oct 1;65(19):9047-55. [Content Brief]
[2]. Wang Y, et al. Targeting HIF1α eliminates cancer stem cells in hematological malignancies. Cell Stem Cell. 2011 Apr 8;8(4):399-411. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9081 mL | 4.5403 mL | 9.0805 mL | 22.7013 mL |
Echinomycin Related Classifications
HY-106101 Related Classifications
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