EF-4-177
EF-4-177 is an orally active and allosteric CDK2 inhibitor with the IC50 of 87 nM. EF-4-177 can disrupt spermatogenesis.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 2891574-93-7
- Fòrmula: C18H14F5N3O2S
- Peso molecular:431.38
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
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CDK2/cyclinE 87 nM (IC50) |
Chemical Information
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No. CAS 2891574-93-7
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Peso molecular 431.38
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Fòrmula C18H14F5N3O2S
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SMILES
N#CC1=CC2=C(C(CCNC3=C(C=C(C=C3)S(F)(F)(F)(F)F)C(O)=O)=CN2)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureza y Documentación
Referencias
[1]. Faber EB, et al. Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice. J Med Chem. 2023;66(3):1928-1940. [Content Brief]
[2]. Huang Y, et al. Targeting cyclin-dependent kinases: From pocket specificity to drug selectivity. Eur J Med Chem. Published online May 29, 2024. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EF-4-177 Related Classifications
HY-161690 Related Classifications
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