F5446
Based on 1 publication(s) in Google Scholar
F5446 (Compound 1) is a selective small molecule inhibitor of SUV39H1 methyltransferase. F5446 decreases H3K9me3 deposition at the FAS promoter, increases Fas expression and increases colorectal carcinoma cell sensitivity to FasL-induced apoptosis in vitro. F5446 suppresses human colon tumor xenograft growth in vivo.
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- Pureza: 99.73%
- No. CAS: 2304465-89-0
- Fòrmula: C26H17ClN2O8S
- Peso molecular:552.94
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) F5446
MoreVer todos los productos específicos de isoformas Histone Methyltransferase
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Actividad biológica
F5446 (0-1 μM, 2 days) has an EC50 of 4.96x10-7 M against recombinant human SUV39H1 and induces apoptotic cell death in the SW620 and LS411N cells[1].
F5446 (0-250 nM, 3 days) up-regulates tumor cell surface Fas expression and increases FasL- induced apoptosis in SW620 and LS411N cells[1][2].
F5446 (100 or 250 nM, 48 h) inhibits SUV39H1 expression and induces human colon tumor cell cycle arrest and apoptosis[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SW620 and LS411N cells
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Concentration:0-1 μM
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Incubation Time:2 days
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Result:Showed the percentage of apoptotic cell death for the SW620 and LS411N cells at various concentrations.
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Cell Line:SW620 and LS411N cells
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Concentration:100 or 250 nM
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Incubation Time:48 h
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Result:Induced cell cycle arrest at the S phase in a concentration-dependent manner in both SW620 and LS411N cells.
IF5446 (10 and 20 mg/kg, s.c.,every two days for 14 days) increases T-cell effector expression to suppress colon carcinoma growth[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2304465-89-0
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Appearance Solid
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Peso molecular 552.94
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Fòrmula C26H17ClN2O8S
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Color Orange to reddish brown
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SMILES
O=C(C1=CC(C2=C(C3=O)NC=C2C(OCC4=CC=CC=C4)=O)=C(N1S(=O)(C5=CC=C(C=C5)Cl)=O)C3=O)OC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Cardiovasc Res
Suppressor of variegation 3-9 homolog 1 deficiency attenuates cardiac fibrosis and rescues heart failure through TACC2. [Abstract]2026 Mar 20:cvag066. PMID: 41861065
Solvente y solubilidad
DMSO : 100 mg/mL (180.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 15% Cremophor EL 85% Saline
Solubility: 2 mg/mL (3.62 mM); Suspended solution; Need ultrasonic
Add each solvent one by one: 10% Cremophor EL in PBS
Solubility: 1.82 mg/mL (3.29 mM); Suspended solution; Need ultrasonic and warming and heat to 60°C
Pureza y Documentación
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Ficha de datos (286 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[2]. Lu C, et al. SUV39H1 regulates human colon carcinoma apoptosis and cell cycle to promote tumor growth. Cancer Lett. 2020 Apr 28;476:87-96. [Content Brief]
[3]. Lu C, et al. SUV39H1 Represses the Expression of Cytotoxic T-Lymphocyte Effector Genes to Promote Colon Tumor Immune Evasion. Cancer Immunol Res. 2019 Mar;7(3):414-427. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8085 mL | 9.0426 mL | 18.0851 mL | 45.2129 mL |
| 5 mM | 0.3617 mL | 1.8085 mL | 3.6170 mL | 9.0426 mL | |
| 10 mM | 0.1809 mL | 0.9043 mL | 1.8085 mL | 4.5213 mL | |
| 15 mM | 0.1206 mL | 0.6028 mL | 1.2057 mL | 3.0142 mL | |
| 20 mM | 0.0904 mL | 0.4521 mL | 0.9043 mL | 2.2606 mL | |
| 25 mM | 0.0723 mL | 0.3617 mL | 0.7234 mL | 1.8085 mL | |
| 30 mM | 0.0603 mL | 0.3014 mL | 0.6028 mL | 1.5071 mL | |
| 40 mM | 0.0452 mL | 0.2261 mL | 0.4521 mL | 1.1303 mL | |
| 50 mM | 0.0362 mL | 0.1809 mL | 0.3617 mL | 0.9043 mL | |
| 60 mM | 0.0301 mL | 0.1507 mL | 0.3014 mL | 0.7535 mL | |
| 80 mM | 0.0226 mL | 0.1130 mL | 0.2261 mL | 0.5652 mL | |
| 100 mM | 0.0181 mL | 0.0904 mL | 0.1809 mL | 0.4521 mL |
F5446 Related Classifications
HY-150190 Related Classifications
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