CD28 - CD28 molecule Gene

Also Known as Tp44

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 940

About CD28

Cytogenetic location: 2q33.2 Genomic coordinates (GRCh38): 2:203,706,465-203,738,912 (from NCBI)

This gene has 3 transcripts (splice variants), 132 orthologues, 1 paralogue and is associated with 58 phenotypes. Biased expression in lymph node (RPKM 11.2), appendix (RPKM 7.3) and 7 other tissues.

Summary

The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

CD28 Products (5)

mRNA	Protein	Name
NM_006139.4	NP_006130.1	T-cell-specific surface glycoprotein CD28 isoform 1 precursor
NM_001243078.2	NP_001230007.1	T-cell-specific surface glycoprotein CD28 isoform 3 precursor
NM_001243077.2	NP_001230006.1	T-cell-specific surface glycoprotein CD28 isoform 2 precursor
XM_011512194.3	XP_011510496.1	T-cell-specific surface glycoprotein CD28 isoform X1
NM_001410981.1	NP_001397910.1	T-cell-specific surface glycoprotein CD28 isoform 4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7568038	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in T cell activation	IDA IDA: Inferred from direct assay	23918985	GOA
involved in T cell activation	IGI IGI: Inferred from genetic interaction	18337562	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23817958	GOA
involved in positive regulation of T cell proliferation	IDA IDA: Inferred from direct assay	3159820	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23817958	GOA
involved in positive regulation of interleukin-10 production	IDA IDA: Inferred from direct assay	8617933	GOA
involved in positive regulation of interleukin-2 production	IDA IDA: Inferred from direct assay	3875683	GOA
involved in positive regulation of interleukin-4 production	IDA IDA: Inferred from direct assay	8617933	GOA
involved in positive regulation of mitotic nuclear division	IDA IDA: Inferred from direct assay	3159820	GOA
involved in regulatory T cell differentiation	IDA IDA: Inferred from direct assay	18641304	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in cell surface	IDA IDA: Inferred from direct assay	15067037	GOA
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	11390434	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11390434	GOA
part of protein complex involved in cell adhesion	IDA IDA: Inferred from direct assay	7544393	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD28 Protein Structure

V-set

0
100
200
220 a.a.

Protein Preferred Names	Protein Names
T-cell-specific surface glycoprotein CD28

CD28 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	CD28	P10747	PIK3R1	Homo sapiens	P27986	CoIP	9417079
Intra	CD28	P10747	PIK3R1	Homo sapiens	P27986	CoIP	8183372
Intra	CD28	P10747	PIK3R1	Homo sapiens	P27986	Anti Bait CoIP	18641334
Intra	CD28	P10747	PIK3R1	Homo sapiens	P27986	CoIP	7584133

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD28 Proteins

Referencia número	Nombre del producto	Accession	Pureza
HY-P7334	CD28 Protein, Human/Cynomolgus/Rhesus Macaque (HEK293, hFc)	P10747-1/Q0PDN3/Q0PDN4 (N19-P152)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70486	CD28 Protein, Human/Cynomolgus/Rhesus Macaque (HEK293, His)	P10747-1/Q0PDN3/Q0PDN4 (N19-P152)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72353	CD28 Protein, Human/Cynomolgus/Rhesus Macaque (Biotinylated, HEK293, Fc-Avi)	P10747-1/Q0PDN3/Q0PDN4 (N19-P152)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74313	CD28 Protein, Human/Cynomolgus/Rhesus Macaque (HEK293)	P10747-1/Q0PDN3/Q0PDN4 (N19-P152)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P78096	CD28 Protein, Human/Cynomolgus/Rhesus Macaque (Biotinylated, HEK293, His-Avi)	P10747-1/Q0PDN3/Q0PDN4 (N19-P152)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78416	CD28 Protein, Human/Cynomolgus/Rhesus Macaque (HEK293, mFc)	P10747-1/Q0PDN3/Q0PDN4 (N19-P152)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78417	CD28 Protein, Human/Cynomolgus/Rhesus Macaque (HEK293, His-Avi)	P10747-1/Q0PDN3/Q0PDN4 (N19-P152)	≥ 95%, as determined by Bis-Tris PAGE.

CD28 Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P81347	CD28 Antibody (YA1092)	IHC-P	Human
HY-P81347A	CD28 Antibody (YA1092)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Mycosis Fungoides	Mycosis Fungoides Lymphoma Alibert-Bazin Syndrome Granuloma Fungoides Classic Mycosis Fungoides Mycosis Fungoides, Alibert-Bazin Type
Lymphoma, Hodgkin, Classic	Hodgkin Lymphoma Hodgkin Disease Hodgkin'S Lymphoma Hodgkins Lymphoma Classic Hodgkin Lymphoma CHL Hodgkin Lymphoma, Susceptibility To Hl Hodgkin'S Sarcoma Stage I Subdiaphragmatic Hodgkin Lymphoma Stage Ii Subdiaphragmatic Hodgkin Lymphoma Lymphoma, Hodgkin'S Classic Hodgkin Disease Hodgkin'S Disease Lymphoma, Hodgkin, Susceptibility To Hodgkin'S Disease Of Intrapelvic Lymph Nodes Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Malignant Lymphogranuloma Malignant Lymphogranulomatosis Malignant Hodgkin Lymphoma Classical Hodgkin Lymphoma, Type Not Specified
Disease By Infectious Agent	Infectious Disease Infectious Diseases
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
T Cell Deficiency	T Cell Immunodeficiency T Lymphocyte Deficiency T Lymphocyte Immunodeficiency T-Lymphocyte Deficiency
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Sarcoidosis 1	Sarcoidosis Boeck Sarcoid Besnier-Boeck-Schaumann Disease SS1 Sarcoidosis, Susceptibility To, 1 Lymphogranulomatosis Hodgkin Disease Boeck'S Disease Boeck'S Sarcoid Schaumann'S Disease Or Syndrome Hutchinson-Boeck Disease Or Syndrome
Human Immunodeficiency Virus Infectious Disease	Hiv Infections
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Demyelinating Disease	Demyelinating Diseases Demyelinating Disorder
Autoimmune Disease Of Eyes, Ear, Nose And Throat
Autoimmune Lymphoproliferative Syndrome	ALPS Canale-Smith Syndrome Autoimmune Lymphoproliferative Syndrome, Type Ia Autoimmune Lymphoproliferative Syndrome, Type Ib Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant Css Autoimmune Lymphoproliferative Syndrome, Type 1b Autoimmune Lymphoproliferative Syndrome, Type 1a Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant Fas Deficiency Autoimmune Lymphoproliferative Syndrome 1a ALPS1A Autoimmune Lymphoproliferative Syndrome Type Ia Autoimmune Lymphoproliferative Syndrome 1b ALPS1B Autoimmune Lymphoproliferative Syndrome Type Ib
Type 1 Diabetes Mellitus 21	Diabetes Mellitus, Insulin-Dependent, 21 Iddm21 T1D21 Insulin-Dependent Diabetes Mellitus 21
Immunodeficiency 16	Combined Immunodeficiency Due To Ox40 Deficiency IMD16 Ox40 Deficiency Combined Immunodeficiency With Childhood-Onset Kaposi Sarcoma Combined Immunodeficiency With Impaired Immunity To Hhv-8 Combined Immunodeficiency With Impaired Immunity To Human Herpes Virus 8 Immunodeficiency, Type 16
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Allergic Disease	Hypersensitivity Allergic Hypersensitivity Disease Allergic Condition Allergic Reaction Allergic Disposition
Pars Planitis	Posterior Cyclitis Vitritis Intermediate Uveitis Peripheral Retinal Inflammation Uveitis, Intermediate
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
B-Cell Expansion With Nfkb And T-Cell Anergy	Benta Disease BENTA B-Cell Expansion With Nf-Kb And T-Cell Anergy Disease Persistent Polyclonal B-Cell Lymphocytosis Lymphocytosis
Granulomatosis With Polyangiitis	GPA Wegener Granulomatosis Wegener Granulomatosis, Formerly Midline Granulomatosis Wg, Formerly Necrotizing Respiratory Granulomatosis Wg Wegeners Granulomatosis Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis
Sialadenitis	Sialoadenitis Adenitis, Salivary Gland Salivary Gland Inflammation Salivary Gland Adenitis Sialitis Inflammation Of Salivary Gland Inflammation Of Salivary Duct Or Gland Salivary Glandular Adenitis Sialoangiitis Sialoangitis Sialodochitis
Autoimmune Cardiomyopathy
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Sphingolipidosis	Sphingolipidoses
Temporal Arteritis	Polymyalgia Rheumatica Giant Cell Arteritis Cranial Arteritis Horton Disease Gca Horton'S Disease Rhizomelic Pseudopolyarthritis Arteritis Cranialis Arteritis Temporalis Horton'S Arteritis Horton'S Giant Cell Arteritis Horton'S Temporal Arteritis Horton'S Syndrome Gca - [Giant Cell Arteritis] Senile Arthritis Polymyalgia Arteritica Pmr - [Polymyalgia Rheumatica] Forestier-Certonciny Syndrome Rheumatic Polymyalgia Polymyalgia
Paracoccidioidomycosis	Mucocutaneous-Lymphangitic Paracoccidioidomycosis Paracoccidioidal Mycosis Lobo Disease Lutz-Splendore-Almeida Disease Pcm Paracoccidioidal Granuloma South American Blastomycosis Lobomycosis Brazilian Blastomycosis Lutz Disease Brazilian Blastomycotic South American Blastomyces Infection Paracoccidioides Brasiliensis Infection Paracoccidioidomycosis Unspecified
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Acquired Hypogammaglobulinemia Common Variable Immune Deficiency Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Wiskott-Aldrich Syndrome	WAS Eczema-Thrombocytopenia-Immunodeficiency Syndrome Immunodeficiency 2 Aldrich Syndrome Imd2 Wiskott-Aldrich Syndrome 1 Was1 Wiskott Syndrome Wiskott Aldrich Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Imd 2
Leukocyte Disease	Leukocyte Disorders
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Goat Milk Allergy	Capra Hircus Milk Allergy
Graves' Disease	Graves Disease Exophthalmic Goiter Basedow'S Disease Grave'S Disease Basedow Disease Toxic Diffuse Goiter Graves' Hyperthyroidism Parry Disease Autoimmune Hyperthyroidism Toxic Multinodular Goiter
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Disease Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Sezary'S Disease	Sezary Syndrome Sézary Syndrome Sezary'S Lymphoma Sezary Disease Sezary Erythroderma Sezary Lymphoma
Chronic Graft Versus Host Disease	Chronic Graft-Versus-Host Disease Chronic Gvhd Chronic Gvhd - [Graft-Versus-Host Disease] Chronic Graft-Versus-Host-Disease
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome
Gaucher'S Disease	Gaucher Disease Kerasin Thesaurismosis Glucocerebrosidase Deficiency Glucosylceramidase Deficiency Acid Beta-Glucosidase Deficiency Glucosylceramide Beta-Glucosidase Deficiency Acute Cerebral Gaucher Disease Cerebroside Lipidosis Syndrome Gaucher Splenomegaly Glucocerebrosidosis Glucosyl Cerebroside Lipidosis Kerasin Lipoidosis Lipoid Histiocytosis Glocucerebrosidase Deficiency Sphingolipidosis 1 Gaucher Syndrome Gauchers Disease Gd Glucosylceramide Lipidosis Kerasin Histiocytosis Gaucher Disease, Type 1 Gaucher Disease, Type 2
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked	IPEX X-Linked Autoimmunity-Allergic Dysregulation Syndrome Xlaad Diarrhea, Polyendocrinopathy, Fatal Infection Syndrome, X-Linked Insulin-Dependent Diabetes Mellitus Secretory Diarrhea Syndrome Iddm-Secretory Diarrhea Syndrome Dmsd Autoimmunity-Immunodeficiency Syndrome, X-Linked Enteropathy, Autoimmune, With Hemolytic Anemia And Polyendocrinopathy Xpid Diabetes Mellitus, Congenital Insulin-Dependent, With Fatal Secretory Diarrhea Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome Ipex Syndrome Polyendocrinopathy, Immune Dysfunction, And Diarrhea, X-Linked Autoimmune Enteropathy Type 1 Immunodeficiency, Polyendocrinopathy, And Enteropathy, X-Linked Immunodeficiency, Polyendocrinopathy, And Enteropathy, X-Linked, Formerly Immunodeficiency, Polyendocrinopathy, Enteropathy X-Linked Syndrome Immunodysregulation, Polyendocrinopathy And Enteropathy X-Linked Autoimmunity-Immunodeficiency Syndrome X-Linked Iddm Secretory Diarrhea Syndrome Polyendocrinopathy, Immune Dysfunction And Diarrhea X-Linked Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome Immunodeficiency Polyendocrinopathy, Enteropathy, X-Linked Syndrome X-Linked Autoimmunity-Immunodeficiency Syndrome Immunodeficiency, Polyendocrinopathy, And Enteropathy X-Linked Syndrome X-Linked Syndrome Of Polyendocrinopathy, Immune Dysfunction, And Diarrhea
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Disease Primary Immunodeficiency Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Autoimmune Uveitis
Aneruptive Fever	Rickettsia Helvetica Spotted Fever
B Cell Deficiency	Immunoglobulin Heavy Chain Deficiency B Cell Deficiencies Immunoglobulin Heavy Chain Deletion Humoral Immune Defect
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Myasthenia Gravis	MG Acquired Myasthenia Autoimmune Myasthenia Gravis Erb-Goldflam Disease Mg - [Myasthenia Gravis] Myasthenia Gravis Nos Myasthenia
Inflammatory Bowel Disease 18	IBD18
Gaucher Disease, Type Ii	GD2 Gd Ii Gaucher Disease, Acute Neuronopathic Type Gaucher Disease Type 2 Gaucher Disease Type Ii Gaucher'S Disease Type Ii Infantile Cerebral Gaucher Disease Acute Neuronopathic Gaucher Disease Gd 2 Gaucher Disease, Infantile Cerebral Gaucher Disease 2 Type 2 Gaucher Disease Gaucher Disease, Type 2
Extrinsic Allergic Alveolitis	Hypersensitivity Pneumonitis Alveolitis Alveolitis, Extrinsic Allergic Allergic Interstitial Pneumonitis Allergic Pneumonitis Extrinsic Allergic Pneumonia Hypersensitivity Pneumonitis Hp Pneumonitis Hypersensitivity Allergic Alveolitis Extrinsic Allergic Alveolitis Nos Airway Obstruction With Allergic Alveolitis Unspecified Allergic Alveolitis And Pneumonitis Extrinsic Allergic Bronchiolo-Alveolitis Hypersensitivity Pneumonia Hypersensitivity Pneumonitis Nos Obstructive Lung Disease With Allergic Alveolitis Obstructive Lung Disorder With Hypersensitivity Pneumonitis Obstructive Lung Disorder With Allergic Alveolitis Obstructive Lung Disease With Hypersensitivity Pneumonitis
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Autoimmune Disease Of Central Nervous System
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Diabetes Mellitus	Diabetes
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Bone Inflammation Disease	Osteitis Bone Inflammatory Disease Inflammatory Disorder Of Bone
Primary Bacterial Infectious Disease
Viral Infectious Disease	Arbovirus Infections Viral Disease Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Autoimmune Disease Of Endocrine System
Autoimmune Disease Of Musculoskeletal System

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Referencia número	Nombre del producto	Efecto	Pureza	Phase
HY-P1698	Reltecimod	Antagonist	98.62%	Phase 3
HY-P1698B	Reltecimod TFA	Chemical	99.78%	Phase 3

Inhibitory Antibodies (12)

Referencia número	Nombre del producto	Efecto	Pureza	Phase
HY-P9986	Tiragolumab	Inhibitor	99.04%	Phase 3
HY-P99293	Galiximab	Inhibitor	99.23%	Phase 3
HY-P99961	Tifcemalimab	Inhibitor	96.02%	Phase 3
HY-P99302	Lulizumab	Inhibitor	≥95.0%	Phase 2
HY-P99420	Acazicolcept	Antagonist	99.27%	Phase 2
HY-P990773	Venanprubart	Inhibitor	98.00%	Phase 2
HY-P99431	KY-1044		99.51%	Phase 2
HY-P99893	Rozibafusp alfa	Inhibitor	96.98%	Phase 2
HY-P990079	Renvistobart	Inhibitor	99.95%	Phase 2
HY-P990752	Nezastomig		/	Phase 2
HY-P991183	SAR-442257	Inhibitor	≥99.0%	Phase 1
HY-P991176	RG-6333	Agonist	98.05%	Phase 1

Pre-clinical Phase

Bioactive Molecules (14)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-122822	GSK699	Activator	98.80%	Unkown
HY-102090	B7/CD28 interaction inhibitor 1		99.81%	Unkown
HY-100891	CD80-IN-3		98.02%	Unkown
HY-19486	UR-1505	Inhibitor	99.97%	Unkown
HY-162810	ICOS-IN-1		/	Unkown
HY-169819	Calcium influx inducer compound 634	Activator	/	Unkown
HY-N10446	Maydispenoid B		/	Unkown
HY-179648	CD28-IN-2	Inhibitor	/	Unkown
HY-176265	DDS5	Inhibitor	/	Unkown
HY-175780	CD28-IN-1	Inhibitor	/	Unkown
HY-184441	CD28-IN-4	Inhibitor	/	Unkown
HY-168384	M04		/	Unkown
HY-181507	CD28-IN-3	Inhibitor	/	Unkown
HY-N10445	Maydispenoid A		/	Unkown

Inhibitory Antibodies (20)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-P9975	Theralizumab	Agonist	99.46%	Unkown
HY-P99123	Anti-Mouse CD28 Antibody (37.51)		95.00%	Unkown
HY-P990865	Anti-CD28 Antibody (9.3)	Inhibitor	99%	Unkown
HY-P990587	FR104	Inhibitor	97.26%	Unkown
HY-P990136	Anti-Monkey/Human CD28 Antibody (CD28.2)	Inhibitor	95.00%	Unkown
HY-P991907	Anti-CD80 Antibody (TKMF5)		96.92%	Unkown
HY-P990298	Anti-Mouse BTLA/CD272 Antibody (6A6)	Inhibitor	95.00%	Unkown
HY-P992125	Radanstobart	Inhibitor	99.12%	Unkown
HY-P991038	Zadoprubart		99%	Unkown
HY-P990237	Anti-Mouse ICOS Antibody (7E.17G9)	Inhibitor	98%	Unkown
HY-P990128	Anti-Rat CD80/B7-1 Antibody (3H5)	Inhibitor	/	Unkown
HY-P992182	ANB032	Agonist	/	Unkown
HY-P992196	Anti-Canine CD28 Antibody (1C6)	Inhibitor	/	Unkown
HY-P991835	Anti-Mouse BTLA/CD272 Antibody (PJ196)	Inhibitor	/	Unkown
HY-P991833	Anti-Mouse BTLA/CD272 Antibody (PK18.6)	Inhibitor	/	Unkown
HY-P990803	Anti-Mouse CD28 Antibody (PV-1)	Inhibitor	96.63%	Unkown
HY-P99123A	Anti-Mouse CD28 (LALA-PG) Antibody (D665)	Inhibitor	/	Unkown
HY-P990793	Anti-Mouse CD28 Antibody (D665)	Inhibitor	/	Unkown
HY-P990137	Anti-Rat CD28 Antibody (JJ319)	Inhibitor	/	Unkown
HY-P990819	Anti-Rat CD28 Antibody (JJ316)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CD28	MGD	MGI:88327
Canis familiaris	CD28	VGNC	VGNC:38944
Macaca mulatta	CD28	VGNC	VGNC:70759
Felis catus	CD28	VGNC	VGNC:60604
Rattus norvegicus	CD28	RGD	RGD:2299
Bos taurus	CD28	VGNC	VGNC:27021
Others	CD28	NCBI