GSK702
GSK702, a PROTAC, is a the less active cis-(S,S)-enantiomer of GSK983 (P300/CBP-associated factor (PCAF)/general control nonderepressible 5 (GCN5) PROTAC). GSK702 induces only a small decrease of PCAF protein levels. GSK702 binds to CRBN and causes a reduction of IL-1β in macrophages. GSK702 can be used for the study of inflammatory mediators.
(Pink: GCN5/PCAF ligand (HY-101027A); Blue: Cereblon ligand (HY-103596); Black: linker).
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- No. CAS: 2260944-69-0
- Fòrmula: C45H51BrN8O7
- Peso molecular:895.84
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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PCAF |
Cereblon |
IL-1β |
Chemical Information
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No. CAS 2260944-69-0
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Peso molecular 895.84
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Fòrmula C45H51BrN8O7
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SMILES
O=C(C1=CC=C([C@H]2CN(C[C@H](C2)NC(C=NN3C)=C(Br)C3=O)C)C=C1)N(C)CCCN(C)C4=CC=C(CCCOC5=C6C(C(N(C6=O)C7C(NC(CC7)=O)=O)=O)=CC=C5)C=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GSK702 Related Classifications
HY-185009 Related Classifications
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