Hericene A
Based on 1 Customer Validation
Hericene A is an orally active aromatic hericene derivative. Hericene A exhibits anti-inflammatory and neurotrophic activities, and can found in the fruiting bodies of Hericium erinaceus. Hericene A inhibits the secretion of pro-inflammatory mediators. Hericene A promotes axonal growth, neurite branching, neurotrophic factor expression and downstream signal transduction. Hericene A can be used for the research of inflammatory and neurological diseases.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.84%
- No. CAS: 157207-54-0
- Fòrmula: C35H56O5
- Peso molecular:556.82
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Actividad biológica
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Actividad biológica
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IL-6 |
Hericene A (0.5-100 μM; 2 h pretreatment) inhibits LPS (HY-D1056)-induced secretion of TNF-α, IL-6 and NO in mouse RAW 264.7 macrophages, with IC50 values of 78.50 µM, 56.33 µM and 87.31 µM, respectively, and does not reduce cell viability at the tested concentrations[1].
Hericene A (10 μg/mL; 24 h) potently promotes axonal growth in primary hippocampal neurons isolated from E18 Sprague Dawley rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7 macrophage cells treated LPS
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Concentration:0.5, 1, 5, 10, 50, 100 μM
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Incubation Time:2 h pretreatment + 24 h LPS stimulation
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Result:Inhibited IL-6 and NO production in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice (male, 6 weeks old, 23-25 g)[2]
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Dosage:5 mg/kg
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Administration:p.o.; daily; 31 days
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Result:Increased brain levels of neurotrophins BDNF, NGF, CNTF, and GDNF.
Increased phosphorylation of neurotrophin receptors TrkB and TrkA.
Increased activation of downstream signaling molecules ERK1/2 and CREB.
Increased levels of synaptophysin (SYP), a synaptic marker.
Increased BDNF immunoreactivity in the dentate gyrus of the hippocampus and cortical regions.
Significantly enhanced novel object recognition performance.
Significantly enhanced spontaneous alternation behavior in the Y-maze test.
Chemical Information
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No. CAS 157207-54-0
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Appearance Solid
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Peso molecular 556.82
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Fòrmula C35H56O5
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Color White to off-white
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SMILES
CCCCCCCCCCCCCCCC(OCC1=C(C(O)=C(C(OC)=C1)C/C=C(C)/CC/C=C(C)\C)C=O)=O
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Pureza y Documentación
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Ficha de datos (267 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Xie G, et al. Secondary Metabolites from Hericium erinaceus and Their Anti-Inflammatory Activities. Molecules. 2022 Mar 27;27(7):2157. [Content Brief]
[2]. Martínez-Mármol R, et al. Hericerin derivatives activates a pan-neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory. J Neurochem. 2023;165(6):791-808. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hericene A Related Classifications
HY-N16499 Related Classifications
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