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United States

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Referencia número: HY-175401

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ICP-103

ICP-103 (Compound 3K) is a highly selective protein kinase C (PKC) inhibitor with an IC₅₀ of 30 nM. ICP-103 is promising for research of cancers.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 153997-72-9
Fòrmula: C₂₄H₁₆N₄O₂
Peso molecular:392.41

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

ICP-103 Chemical Structure

No. CAS: 153997-72-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica

Descripciòn

ICP-103 (Compound 3K) is a highly selective protein kinase C (PKC) inhibitor with an IC₅₀ of 30 nM. ICP-103 is promising for research of cancers^[1]^[2].

Ver todos los productos específicos de isoformas PKC :

Chemical Information

No. CAS 153997-72-9
Peso molecular 392.41
Fòrmula C₂₄H₁₆N₄O₂
SMILES

N#CCCN(C1=C2C(C(NC3=O)=O)=C3C4=C1N(C)C5=C4C=CC=C5)C6=C2C=CC=C6
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocolo

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Kleinschroth J, Hartenstein J, Rudolph C, et al. Novel indolocarbazole protein kinase C inhibitors with improved biochemical and physicochemical properties[J]. Bioorganic & Medicinal Chemistry Letters, 1995, 5(1): 55-60.

[2]. Roy S, Eastman A, Gribble G W. Synthesis of 7‐keto‐Gö6976 (ICP‐103)[J]. Synthetic communications, 2005, 35(4): 595-601.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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