Ischemin
Based on 1 Customer Validation
Ischemin is a CBP bromodomain inhibitor that inhibits p53 interaction with CBP and transcriptional activity in cells. Ischemin inhibits p53-induced p21 activation with an IC50 value of 5 µM. Ischemin also prevents apoptosis in ischemic cardiomyocytes. Ischemin can be used in the study of cardiovascular diseases (such as myocardial ischemia).
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- Pureza : 99.80%
- No. CAS: 1357059-00-7
- Fòrmula: C15H17N3O4S
- Peso molecular:335.38
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Chemical Information
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| U2OS | IC50 |
5 μM
Compound: 23
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Inhibition of p53-CBP bromodomain interaction in human U2OS cells assessed as inhibition of p21 activation incubated overnight followed by doxorubicin addition measured after 24 hrs by luciferase reporter gene assay
Inhibition of p53-CBP bromodomain interaction in human U2OS cells assessed as inhibition of p21 activation incubated overnight followed by doxorubicin addition measured after 24 hrs by luciferase reporter gene assay
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[PMID: 26701186] |
| U2OS | IC50 |
5 μM
Compound: 5, MS210
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Inhibition of p53-induced p21 expression in human U2OS cells by luciferase reporter gene assay
Inhibition of p53-induced p21 expression in human U2OS cells by luciferase reporter gene assay
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10.1039/C1MD00201E |
In Vitro
Ischemin (50, 100 µM; 24 h) inhibits p53 activation on DNA damaging stress in U2OS cells[1].
Ischemin (10 μM; 3 days) blocks apoptosis in cardiomyocytes by inhibiting caspase 3/7 activity[1].
Ischemin inhibits p53 cellular signaling pathways in U2OS cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U2OS cells
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Concentration:50, 100 μM
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Incubation Time:24 h
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Result:Inhibited the Doxorubicin-induced increased levels of p53 protein, its Ser15-phosphorylated (p53S15p) and Lys382-acetylated (p53K382ac).
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Cell Line:U2OS cells
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Concentration:10 μM
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Incubation Time:3 days
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Result:Functioned as a cellular protective agent againsted myocardial ischemic stress.
Chemical Information
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No. CAS 1357059-00-7
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Appearance Solid
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Peso molecular 335.38
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Fòrmula C15H17N3O4S
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Color White to off-white
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SMILES
O=S(C1=CC(/N=N/C2=CC(C)=C(O)C=C2N)=C(C)C=C1C)(O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ischemin Related Classifications
HY-110315A Related Classifications
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