Licarin A
Based on 1 Customer Validation
Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC50=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and COX-2 expression.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.83%
- No. CAS: 51020-86-1
- Fòrmula: C20H22O4
- Peso molecular:326.39
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Ver todos los productos específicos de isoformas TNF Receptor
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Actividad biológica
Descripciòn
IC50 & Target
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DP |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Platelet | IC50 |
>999 μM
Compound: 19
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Antiplatelet activity in rabbit platelets assessed as inhibition of platelet activating factor-induced platelet aggregation
Antiplatelet activity in rabbit platelets assessed as inhibition of platelet activating factor-induced platelet aggregation
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[PMID: 19880317] |
| Platelet | IC50 |
165 μM
Compound: 19
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Antiplatelet activity in rabbit platelets assessed as inhibition of adenosin 5'-diphosphate-induced platelet aggregation
Antiplatelet activity in rabbit platelets assessed as inhibition of adenosin 5'-diphosphate-induced platelet aggregation
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[PMID: 19880317] |
| Platelet | IC50 |
556 μM
Compound: 19
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Antiplatelet activity in rabbit platelets assessed as inhibition of arachidonic acid-induced platelet aggregation
Antiplatelet activity in rabbit platelets assessed as inhibition of arachidonic acid-induced platelet aggregation
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[PMID: 19880317] |
In Vitro
Licarin A is found in plants such as Aristolochia taliscana, Machilus thunbergii and Myristica fragrans, which are used as spices and in folk medicines for nervous and digestive disorders. Licarin A also exhibits anti-inflammatory effects[1].
Licarin A (5-20 μM) reduces TNF-α and prostaglandin D2 (PGD2) secretion via the inhibition of PKCα/βII and p38 MAPK pathways. Licarin A treatment tends to reduce phosphorylated PKCα/βII and p38 MAPK protein levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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No. CAS 51020-86-1
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Appearance Solid
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Peso molecular 326.39
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Fòrmula C20H22O4
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Color White to off-white
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SMILES
OC1=CC=C([C@@H]2OC3=C(OC)C=C(/C=C/C)C=C3[C@H]2C)C=C1OC
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Synonyms
(+)-Licarin A
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvente y solubilidad
In Vitro:
DMSO : ≥ 50 mg/mL (153.19 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocolo
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RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0638 mL | 15.3191 mL | 30.6382 mL | 76.5955 mL |
| 5 mM | 0.6128 mL | 3.0638 mL | 6.1276 mL | 15.3191 mL | |
| 10 mM | 0.3064 mL | 1.5319 mL | 3.0638 mL | 7.6595 mL | |
| 15 mM | 0.2043 mL | 1.0213 mL | 2.0425 mL | 5.1064 mL | |
| 20 mM | 0.1532 mL | 0.7660 mL | 1.5319 mL | 3.8298 mL | |
| 25 mM | 0.1226 mL | 0.6128 mL | 1.2255 mL | 3.0638 mL | |
| 30 mM | 0.1021 mL | 0.5106 mL | 1.0213 mL | 2.5532 mL | |
| 40 mM | 0.0766 mL | 0.3830 mL | 0.7660 mL | 1.9149 mL | |
| 50 mM | 0.0613 mL | 0.3064 mL | 0.6128 mL | 1.5319 mL | |
| 60 mM | 0.0511 mL | 0.2553 mL | 0.5106 mL | 1.2766 mL | |
| 80 mM | 0.0383 mL | 0.1915 mL | 0.3830 mL | 0.9574 mL | |
| 100 mM | 0.0306 mL | 0.1532 mL | 0.3064 mL | 0.7660 mL |
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