Referencia número: HY-126114

Lupeol acetate

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Lupeol acetate is a derivative of Lupeol. Lupeol acetate is an anti-inflammatory, antibacterial, anti-trypanosomic and anticancer agent with oral activity. Lupeol acetate significantly improves the symptoms of rheumatoid arthritis by down-regulating the expression of inflammatory cytokines and osteoclast production. Lupeol acetate inhibits spermatogenesis in male rats and eventually led to infertility.

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Pureza: 98.0%
No. CAS: 1617-68-1
Fòrmula: C₃₂H₅₂O₂
Peso molecular:468.75

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Lupeol acetate Chemical Structure

No. CAS: 1617-68-1

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

COX-2

Ver todos los productos específicos de isoformas COX :

Ver todos los productos específicos de isoformas Interleukin Related :

Ver todos los productos específicos de isoformas Parasite :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	15 μg/mL Compound: 6	Cytotoxicity against human A2780 cells Cytotoxicity against human A2780 cells	[PMID: 12193040]
A2780	IC₅₀	16 μg/mL Compound: 5	Cytotoxicity against human A2780 cells Cytotoxicity against human A2780 cells	[PMID: 12662105]
A2780	IC₅₀	22.6 μg/mL Compound: Lupeyl acetate	Cytotoxicity against human A2780 cells Cytotoxicity against human A2780 cells	[PMID: 15165160]
A549	IC₅₀	29.826 μM Compound: Compound 9	Cytotoxicity against human A549 cells assessed as cell growth inhibition by MTT assay Cytotoxicity against human A549 cells assessed as cell growth inhibition by MTT assay	[PMID: 27913179]
B16	ED₅₀	7.5 μM Compound: 3	Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days	[PMID: 12027734]
B16	IC₅₀	22.7 μM Compound: 3	Growth inhibition of mouse B16 2F2 cells after 3 days Growth inhibition of mouse B16 2F2 cells after 3 days	[PMID: 12027734]
Hep 3B2	IC₅₀	18.692 μM Compound: Compound 9	Cytotoxicity against human Hep3B cells assessed as cell growth inhibition by MTT assay Cytotoxicity against human Hep3B cells assessed as cell growth inhibition by MTT assay	[PMID: 27913179]
J774.A1	IC₅₀	33.2 μM Compound: 5	Antiinflammatory activity in mouse J774A1 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS challenge measured after 24 hrs by Griess method Antiinflammatory activity in mouse J774A1 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS challenge measured after 24 hrs by Griess method	[PMID: 24909081]
RAW264.7	IC₅₀	>0.4 μM Compound: lupenyl acetate	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release after 24 hrs Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release after 24 hrs	[PMID: 20192236]
RAW264.7	IC₅₀	36.7 μM Compound: 5	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS challenge measured after 24 hrs by Griess method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS challenge measured after 24 hrs by Griess method	[PMID: 24909081]

In Vitro

Lupeol acetate (3.125-100mg/mL; 7 days) inhibits the growth of M. phaseolina with a bacteriostatic rate of 79-81%^[1].
Lupeol acetate (3-94 µg/mL; 24-48 h) induces death of trypomastigote with an EC₅₀ of 15.82 µg/mL and an inhibition of amastigote stage with an IC₅₀ of 32.55 µg/mL^[2].
Lupeol acetate (0-80 μM; 25 h) inhibits the activation and expression of TNF-α and IL-1β in LPS (HY-D1056) -treated RAW 264.7 and BMDMs cells^[3].
Lupeol acetate (0-80 μM; 25 h) decreases the migration ability of macrophages by down-regulating the expression of COX-2 and MCP-1 and blocks osteoclast differentiation mediated by RANKL^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[3]

Cell Line:

LPS(HY-D1056) treated RAW 264.7 cells
Concentration:

0, 10, 20, 40 and 80 μM
Incubation Time:

25 h
Result:

Reduced the levels of COX-2 and MCP-1.

In Vivo

Lupeol acetate (50 mg/kg; Intraperitoneal injection; 21 days) shows improvement in the mouse model of rheumatoid arthritis^[3].
Lupeol acetate (10 mg/day; Oral administration; 60 days) plays an anti-fertility role in male rats^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

DBA/1J mouse aged 8 weeks old with collagen-induced arthritis^[3]
Dosage:

50 mg/kg
Administration:

Intraperitoneal injection (i.p.); 21 days
Result:

Reduced the incidence of arthritis and relieved symptoms of rheumatoid arthritis.
Significantly decreased clinical score and paw thickness.
Significantly lowered TNF-α and IL-1β levels in serum.
Inhibited inflammatory activity, significantly decreased the accumulation of ¹⁸F-FDG in the joints.
Reduced the infiltration of macrophages and bone erosion.

Animal Model:

Male albino rats of the Wistar strain aged 3.5-4 months old (170 and 200 g)^[4]
Dosage:

10 mg/day
Administration:

Oral administration (p.o.); 60 days
Result:

Did not cause any significant change in the body weights, but significantly reduced in the weight of reproductive organs, i.e. testes, epididymides, seminal vesicle and ventral prostate.
Significantly declined testicular sperm count, epididymal sperm count and motility, which resulted in reduction of male fertility by 100%.
Interfered with spermatogenesis and significantly reduced most tubule cell types.
Significantly reduced biochemical parameters of tissues i.e. protein, sialic acid, glycogen and cholesterol content of testes and seminal vesicular fructose.

Chemical Information

No. CAS 1617-68-1
Appearance Solid
Peso molecular 468.75
Fòrmula C₃₂H₅₂O₂
Color White to off-white
SMILES

C[C@@]([C@@]1(CC[C@@]2([H])C3(C)C)C)(CC4)[C@@](CC[C@]1([H])[C@]2(CC[C@@H]3OC(C)=O)C)([H])[C@]([C@@H]5C(C)=C)([H])[C@@]4(CC5)C
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
- Plants
- Umbelliferae
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Trop Med Infect Dis

Lupeol Acetate and α-Amyrin Terpenes Activity against Trypanosoma cruzi: Insights into Toxicity and Potential Mechanisms of Action. [Abstract]

2023 May 3;8(5):263. PMID: 37235311

Solvente y solubilidad

In Vitro:

Ethanol : ≥ 2 mg/mL (4.27 mM)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1333 mL

10.6667 mL

21.3333 mL

5 mM

---

10 mM

---

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (283 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Javed S, et al. Lupeol acetate as a potent antifungal compound against opportunistic human and phytopathogenic mold Macrophomina phaseolina. Sci Rep. 2021 Apr 19;11(1):8417. [Content Brief]

[2]. Pardo-Rodriguez D, et al. Lupeol Acetate and α-Amyrin Terpenes Activity against Trypanosoma cruzi: Insights into Toxicity and Potential Mechanisms of Action. Trop Med Infect Dis. 2023 May 3;8(5):263. [Content Brief]

[3]. Wang WH, et al. Lupeol acetate ameliorates collagen-induced arthritis and osteoclastogenesis of mice through improvement of microenvironment. Biomed Pharmacother. 2016;79:231-240. [Content Brief]

[4]. Gupta RS, et al. Induction of antifertility with lupeol acetate in male albino rats. Pharmacology. 2005 Oct;75(2):57-62. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
Ethanol	1 mM	2.1333 mL	10.6667 mL	21.3333 mL	53.3333 mL

Keywords

Lupeol acetate

1 Cited Publications

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Lupeol acetate

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Publications Citing Use of MedChemExpress (MCE) Lupeol acetate

Ver todos los productos específicos de isoformas COX

Ver todos los productos específicos de isoformas Interleukin Related

Ver todos los productos específicos de isoformas Parasite

Actividad biológica

Chemical Information

Publications (1)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

Lupeol acetate Related Classifications

HY-126114 Related Classifications