Mancozeb
Based on 1 Customer Validation
Mancozeb is a widely used fungicide that is effective against fungal diseases in most cereals, vegetables, fruits and ornamental plants. In addition, Mancozeb can cause liver damage in mice by activating the Keap1/Nrf2 signaling pathway. Mancozeb upregulates lactate dehydrogenase and cytochrome c to alter cell metabolism and induce cell death. Mancozeb has reproductive toxicity and can induce apoptosis in ovarian cells.
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- Pureza: 85.50%
- No. CAS: 8018-01-7
- Fòrmula: C8H12Mn2N4S8Zn22-
- Peso molecular:661.36
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Mancozeb (0.1-500 ppm; 24-48 h) is highly toxic to HepG2 cells, and can affect cell metabolism and induce cell damage[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 cells
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Concentration:0.1, 1, 10, 100 and 500 ppm;
1, 10 and 100 ppm -
Incubation Time:24 h;
48 h -
Result:Was toxic to cells at all concentrations.
Reduced cell viability (to below 50%) at 24 h, resulted in total cell death with a 48-hour exposure to 100ppm.
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Cell Line:HepG2 cells
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Concentration:0.1, 1, 10 and 100 ppm
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Incubation Time:24 h and 48 h
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Result:Reduced the levels of LDH and cytochrome c.
Mancozeb (100 mg/kg; Gavage; 30 days) can cause ovarian injury and apoptosis in mice[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Kunming mice aged 6 weeks old[3]
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Dosage:0, 50, 100, 150, 200, 250 and 300 mg/kg
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Administration:Oral administration (p.o.); 30 days
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Result:Reduced body weight in mice in a concentration-dependent manner.
Significantly reduced the liver organ index of mice at doses of 250 mg/kg and 300 mg/kg.
Reduced the levels of CAT, SOD and ROS in a concentration-dependent manner.
Significantly up-regulated the levels of Keap1 and Nrf2 in the liver.
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Animal Model:Kunming mice aged 6 weeks old[4]
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Dosage:100 mg/kg
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Administration:Oral gavage (i.g.); 30 days
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Result:Reduced body weight in mice.
Destroyed the ovary structure of mice and decreased the levels of follicle stimulating hormone and luteinizing hormone.
Caused mitochondrial oxidative phosphorylation dysfunction and oxidative stress.
Activated the Bax/Bcl-2 pathway and caspase family, thereby inducing apoptosis.
Chemical Information
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No. CAS 8018-01-7
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Appearance Solid
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Peso molecular 661.36
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Fòrmula C8H12Mn2N4S8Zn22-
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Color Light yellow to yellow
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SMILES
S=C([S-])NCCNC1=[S][Mn]([Mn+])[S-]1.S=C([S-])NCCNC2=[S][Zn]([Zn+])[S-]2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvente y solubilidad
DMSO : 1 mg/mL (1.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (283 KB)
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SDS (761 KB)
- English - EN (761 KB)
- Français - FR (761 KB)
- Deutsch - DE (761 KB)
- Norwegian - NO (761 KB)
- Español - ES (761 KB)
- Swedish - SV (761 KB)
- Italian - IT (761 KB)
- Korean - KR (761 KB)
- Portuguese - PT (761 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Santos R, er al. Thyroid and reproductive hormones in relation to pesticide use in an agricultural population in Southern Brazil. Environ Res. 2019 Jun;173:221-231. [Content Brief]
[2]. WENX Pirozzi AV, et al. Mancozeb, a fungicide routinely used in agriculture, worsens nonalcoholic fatty liver disease in the human HepG2 cell model. Toxicol Lett. 2016 May 13;249:1-4. [Content Brief]
[3]. Gao N, et al. The administration of Glycyrrhiza polysaccharides mitigates liver injury in mice caused by mancozeb via the Keap1-Nrf2/NF-κB pathway. Food Chem Toxicol. 2024 Nov 4:115088. [Content Brief]
[4]. Bao J, et al. Low level of mancozeb exposure affects ovary in mice. Ecotoxicol Environ Saf. 2022 Jul 1;239:113670. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5120 mL | 7.5602 mL | 15.1204 mL | 37.8009 mL |
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