Mesendogen
Based on 1 publication(s) in Google Scholar
Mesendogen is a TRPM6 inhibitor. Mesendogen enhances the mesoderm and definitive endoderm (DE) differentiations of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). Mesendogen can be used for the research of magnesium homeostasis during early embryonic cell development.
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- Pureza: 99.84%
- No. CAS: 864716-85-8
- Fòrmula: C18H16ClF3N2OS
- Peso molecular:400.85
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Mesendogen
More
Actividad biológica
Mesendogen (10 μM) induces hESC mesoderm and endoderm differentiation, and decreases the level of neural differentiation markers[1]. Mesendogen (2.5, 10 and 25 μM; overnight) dose-dependently reduces intracellular magnesium level in H1 hESCs[1]. Mesendogen (10 μM; 7 days) inhibits the neural differentiation activity induced by Dorsomorphin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:H9 hESCs
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Concentration:10 μM
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Incubation Time:7 days
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Result:Downregulated expression levels of pluripotency markers OCT4 and SOX2.
Chemical Information
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No. CAS 864716-85-8
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Appearance Solid
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Peso molecular 400.85
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Fòrmula C18H16ClF3N2OS
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Color White to off-white
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SMILES
O=C(NC(NC1=CC(C(F)(F)F)=CC=C1Cl)=S)C2=CC=C(C(C)C)C=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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World J Gastrointest Oncol
Transient receptor potential melastatin 6 and transient receptor potential melastatin 6/7 antagonists suppress colon adenocarcinoma HT-29 cells. [Abstract]2025 Dec 15;17(12):110736. PMID: 41480213
Solvente y solubilidad
DMSO : 100 mg/mL (249.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4947 mL | 12.4735 mL | 24.9470 mL | 62.3675 mL |
| 5 mM | 0.4989 mL | 2.4947 mL | 4.9894 mL | 12.4735 mL | |
| 10 mM | 0.2495 mL | 1.2473 mL | 2.4947 mL | 6.2367 mL | |
| 15 mM | 0.1663 mL | 0.8316 mL | 1.6631 mL | 4.1578 mL | |
| 20 mM | 0.1247 mL | 0.6237 mL | 1.2473 mL | 3.1184 mL | |
| 25 mM | 0.0998 mL | 0.4989 mL | 0.9979 mL | 2.4947 mL | |
| 30 mM | 0.0832 mL | 0.4158 mL | 0.8316 mL | 2.0789 mL | |
| 40 mM | 0.0624 mL | 0.3118 mL | 0.6237 mL | 1.5592 mL | |
| 50 mM | 0.0499 mL | 0.2495 mL | 0.4989 mL | 1.2473 mL | |
| 60 mM | 0.0416 mL | 0.2079 mL | 0.4158 mL | 1.0395 mL | |
| 80 mM | 0.0312 mL | 0.1559 mL | 0.3118 mL | 0.7796 mL | |
| 100 mM | 0.0249 mL | 0.1247 mL | 0.2495 mL | 0.6237 mL |
Mesendogen Related Classifications
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