Methicillin
Based on 7 publication(s) in Google Scholar
Methicillin is a narrow-spectrum β-lactam antibiotic, acts by inhibiting penicillin-binding proteins (PBPs). Methicillin is active against Staphylococcus aureus and Staphylococcus epidermidis that are resistant to other penicillins.Methicillin can be used for the research of skin infections, osteomyelitis, and endocarditis.
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- No. CAS: 61-32-5
- Fòrmula: C17H20N2O6S
- Peso molecular:380.42
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Publications Citing Use of MedChemExpress (MCE) Methicillin
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Actividad biológica
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β-lactam |
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Cell Line
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Type | Value | Description | References |
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| CHO | IC50 |
116 μM
Compound: Methicillin
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Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
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[PMID: 23344796] |
| Vero | CC50 |
>200 μM
Compound: Methicillin
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Cytotoxicity against African green monkey Vero cells
Cytotoxicity against African green monkey Vero cells
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[PMID: 27036520] |
Methicillin (20 μg/mL, 24 h) results in a rapid decrease in CFU of S. aureus[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 61-32-5
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Peso molecular 380.42
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Fòrmula C17H20N2O6S
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SMILES
OC([C@@H]1N(C2=O)[C@@](SC(C)1C)([H])[C@@H]2NC(C(C(OC)=CC=C3)=C3OC)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (7)
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Journal Impact Factor
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Most Recent
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Sci Rep
Anandamide alters the membrane properties, halts the cell division and prevents drug efflux in multidrug resistant Staphylococcus aureus. [Abstract]2021 Apr 22;11(1):8690. PMID: 33888802 -
Biomed Res Int
In Vitro Activity of β-Lactams in Combination with β-Lactamase Inhibitors against Mycobacterium tuberculosis Clinical Isolates. [Abstract]2018 Jul 2:2018:3579832. PMID: 30065936 -
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Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Methicillin Related Classifications
HY-121544 Related Classifications
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