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Referencia número: HY-122640

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NPD13668

NPD13668 is an EZH2-mediated gene silencing modulator. NPD13668 inhibits EZH2/PRC2 (polycomb repressive complex 2) activity. NPD13668 reactivates the expression of silenced H3K27me3 target genes together with depletion of the H3K27me3 modification. NPD13668 can be used for the study of prostate cancer and ovarian cancer.

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No. CAS: 864819-54-5
Fòrmula: C₂₂H₂₀N₂O₅
Peso molecular:392.40

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

NPD13668 Chemical Structure

No. CAS: 864819-54-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

EZH2

Ver todos los productos específicos de isoformas Histone Methyltransferase :

Chemical Information

No. CAS 864819-54-5
Peso molecular 392.40
Fòrmula C₂₂H₂₀N₂O₅
SMILES

O=C(NCCC1=CNC2=C1C=CC=C2)CC3=C(C)C4=CC=C(O)C(O)=C4OC3=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Murashima A, et al. Identification of a chemical modulator of EZH2-mediated silencing by cell-based high-throughput screening assay. J Biochem. 2019 Jul 1;166(1):41-50. [Content Brief]

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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NPD13668

Ver todos los productos específicos de isoformas Histone Methyltransferase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

NPD13668 Related Classifications

HY-122640 Related Classifications