PD-M6
Based on 1 Customer Validation
PD-M6 is a mTOR PROTAC degrader (DC50: 4.8 μM). PD-M6 promotes ubiquitination and degradation of mTOR. PD-M6 downregulates MAPKAP1 and CASTOR1, and induces Autophagy. PD-M6 inhibits the proliferation of cervical cancer, breast cancer and liver cancer cell lines. PD-M6 can be used for the research of cervical cancer, breast cancer and liver cancer.
(Pink: mTOR ligand (HY-B0795); Blue: Cereblon ligand (HY-41547); Black: linker (HY-W008296)).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.17%
- No. CAS: 3058330-82-5
- Fòrmula: C30H39N9O6
- Peso molecular:621.69
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
PD-M6 (0.001-10 μM; 4-24 h) induces dose- and time-dependent degradation of mTOR in HeLa cells, with a DC50 of 4.8 μM[1].
PD-M6 inhibits the proliferation of HeLa, MCF-7 and HepG2 cancer cells, with IC50 values of 11.3 μM, 2.58 μM and 3.23 μM, respectively[1].
PD-M6 (0.1-10 μM; 4 days) inhibits long-term colony formation of HeLa cells[1].
PD-M6 (10 μM) inhibits the migration of HeLa cells with an inhibition rate of over 50%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells
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Concentration:0.001-10 μM
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Incubation Time:4 h, 12 h, 24 h
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Result:Induced a dose-dependent reduction in mTOR levels, with significant degradation observed at 1 μM and maximum degradation (~90%) at 10 μM after 12 h.
Achieved a DC50 for mTOR degradation of 4.8 μM.
Reduced mTOR levels by ~50% at 4 h and ~90% at 24 h at 10 μM.
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Cell Line:HeLa cells
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Concentration:0.1-10 μM
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Incubation Time:4 days
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Result:Reduced HeLa cell colony formation in a concentration-dependent manner, with nearly 90% suppression of proliferation observed at 10 μM.
Chemical Information
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No. CAS 3058330-82-5
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Appearance Solid
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Peso molecular 621.69
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Fòrmula C30H39N9O6
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Color Light yellow to yellow
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SMILES
O=C1N(C2CCC(NC2=O)=O)C(C3=CC=CC(NCCCCCCNC4=NC(N5CCOCC5)=NC(N6CCOCC6)=N4)=C13)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (160.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6085 mL | 8.0426 mL | 16.0852 mL | 40.2130 mL |
| 5 mM | 0.3217 mL | 1.6085 mL | 3.2170 mL | 8.0426 mL | |
| 10 mM | 0.1609 mL | 0.8043 mL | 1.6085 mL | 4.0213 mL | |
| 15 mM | 0.1072 mL | 0.5362 mL | 1.0723 mL | 2.6809 mL | |
| 20 mM | 0.0804 mL | 0.4021 mL | 0.8043 mL | 2.0106 mL | |
| 25 mM | 0.0643 mL | 0.3217 mL | 0.6434 mL | 1.6085 mL | |
| 30 mM | 0.0536 mL | 0.2681 mL | 0.5362 mL | 1.3404 mL | |
| 40 mM | 0.0402 mL | 0.2011 mL | 0.4021 mL | 1.0053 mL | |
| 50 mM | 0.0322 mL | 0.1609 mL | 0.3217 mL | 0.8043 mL | |
| 60 mM | 0.0268 mL | 0.1340 mL | 0.2681 mL | 0.6702 mL | |
| 80 mM | 0.0201 mL | 0.1005 mL | 0.2011 mL | 0.5027 mL | |
| 100 mM | 0.0161 mL | 0.0804 mL | 0.1609 mL | 0.4021 mL |
PD-M6 Related Classifications
HY-176166 Related Classifications
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