Peplomycin
Peplomycin (Bleomycin PEP) is an analog of Bleomycin (HY-108345) and an antitumor antibiotic. Peplomycin exhibits potent antitumor activity and relatively low pulmonary toxicity. Peplomycin can induce various skin abnormalities and trigger apoptosis in SSCKN cells of oral squamous cell carcinoma. Peplomycin can also induce pulmonary fibrosis. Peplomycin is applicable for the research of tumors, pulmonary fibrosis and other related diseases.
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- No. CAS: 68247-85-8
- Fòrmula: C61H88N18O21S2
- Peso molecular:1473.59
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Peplomycin (0-100 μM; 30 h) inhibits human oral squamous carcinoma cell line SSCKN and SCCTF cells in a dose-dependent manner[3].
Peplomycin (1 μM and 10 μM; 30 h) results nuclear fragmentation and condensation of chromatin in cells dose-dependently and induces apoptosis[3].
Peplomycin (5 mg/mL; 7 d) induces pulmonary fibrosis separated from saline-injected rats (N-Fib) by differentiating fibroblasts to alpha-SMA-positive MF[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SSCKN and SCCTF cells
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Concentration:0, 1, 5, 10, 50, and 100 μM
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Incubation Time:30 hours
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Result:Decreased SSCKN and SCCTF cells viability dose-dependently up to 50 μM, and resulted the viability of 38% and 30% that of the control group, respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 68247-85-8
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Peso molecular 1473.59
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Fòrmula C61H88N18O21S2
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SMILES
O=C(C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C)N[C@@](C(N[C@H](C)[C@@H](O)[C@H](C)C(N[C@]([C@H](O)C)([H])C(NCCC2=NC(C3=NC(C(NCCCN[C@H](C4=CC=CC=C4)C)=O)=CS3)=CS2)=O)=O)=O)([H])[C@H](C5=CNC=N5)O[C@H]6[C@H]([C@H]([C@H](O)[C@H](CO)O6)O)O[C@]7([H])[C@H]([C@H]([C@H](O)[C@@H](CO)O7)OC(N)=O)O
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Synonyms
Bleomycin PEP; Pepleomycin
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Carter SK, et al. Peplomycin. Cancer Treat Rev. 1984 Dec;11(4):303-5. [Content Brief]
[2]. Asano Y, et al. A case of peplomycin-induced scleroderma. Br J Dermatol. 2004 Jun;150(6):1213-4. [Content Brief]
[3]. Okamura H, et al. Peplomycin-induced apoptosis in oral squamous carcinoma cells depends on bleomycin sensitivity. Oral Oncol. 2001 Jun;37(4):379-85. [Content Brief]
[4]. Osaki T, et al. Peplomycin, a bleomycin derivative, induces myofibroblasts in pulmonary fibrosis. Int J Exp Pathol. 2001 Aug;82(4):231-41. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Peplomycin Related Classifications
HY-106364 Related Classifications
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