Phillyrin
Based on 8 publication(s) in Google Scholar
Phillyrin is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities. Phillyrin has potential inductive effects on rat CYP1A2 and CYP2D1 activities, without affecting CYP2C11 and CYP3A1/2 activities. Phillyrin has anti-influenza A virus activities.
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- Pureza: 98.82%
- No. CAS: 487-41-2
- Fòrmula: C27H34O11
- Peso molecular:534.55
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) Phillyrin
More- Phytomedicine. 2025 May:140:156484. [Abstract]
- Phytomedicine. 2024 Aug 18:134:155952. [Abstract]
- Int Immunopharmacol. 2024 Aug 18:141:112960. [Abstract]
- Front Cell Dev Biol. 2021 Nov 10;9:763864. [Abstract]
- Food Sci Nutr. 2025 Oct 23;13(10):e71069. [Abstract]
- J Dent Sci. 2025 Dec 24.
- J Orthop Surg Res. 2024 May 22;19(1):308. [Abstract]
- Vet Microbiol. 2026 May:316:110992. [Abstract]
Customer Validation & Images
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Cell Proliferation/Viability Assay
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Flow Cytometry
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Cell Migration/Invasion Assay
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WB
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Cell Imaging/Staining
Actividad biológica
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CYP1 |
CYP2 |
Phillyrin (1–5 μM; pretreatment 1 hour; 24 hours) inhibits high glucose-induced FAS protein significantly in HepG2 cells[1]. Phillyrin (1–5 μM; pretreatment 1 hour; 24 hours) inhibits high glucose-induced FAS mRNA expression by suppressing SREBP-1c activation in human HepG2 hepatocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human HepG2 hepatocyte cells
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Concentration:1 μM; 2.5 μM; 5 μM
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Incubation Time:24 hours
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Result:Reduced FAS and SREBP-1c mRNA expression.
Chemical Information
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No. CAS 487-41-2
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Appearance Solid
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Peso molecular 534.55
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Fòrmula C27H34O11
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Color White to off-white
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SMILES
COC(C=C1[C@@H]2[C@](CO[C@H]3C4=CC(OC)=C(OC)C=C4)([H])[C@]3([H])CO2)=C(C=C1)O[C@@H]([C@@H]([C@@H](O)[C@@H]5O)O)O[C@@H]5CO
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (8)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Fangchinoline suppresses nasopharyngeal carcinoma progression by inhibiting SQLE to regulate the PI3K/AKT pathway dysregulation. [Abstract]2025 May:140:156484. PMID: 40090046 -
Phytomedicine
Phillyrin promotes autophagosome formation in A53T-αSyn-induced Parkinson's disease model via modulation of REEP1. [Abstract]2024 Aug 18:134:155952. PMID: 39178680 -
Int Immunopharmacol
Phillyrin: A potential therapeutic agent for osteoarthritis via modulation of NF-κB and Nrf2 signaling pathways. [Abstract]2024 Aug 18:141:112960. PMID: 39159565 -
Front Cell Dev Biol
Curdione and Schisandrin C Synergistically Reverse Hepatic Fibrosis via Modulating the TGF-β Pathway and Inhibiting Oxidative Stress. [Abstract]2021 Nov 10;9:763864. PMID: 34858986 -
Food Sci Nutr
Network Pharmacology and Molecular Docking Elucidate the Mechanism of Phillyrin in Colorectal Cancer. [Abstract]2025 Oct 23;13(10):e71069. PMID: 41142018
Phillyrin purchased from MedChemExpress. Usage Cited in: Food Sci Nutr. 2025 Oct 23;13(10):e71069. [Abstract]
The cell viability of HT29 and HCT116 was detected by CCK8 assays treated with Phillyrin.
Phillyrin purchased from MedChemExpress. Usage Cited in: Food Sci Nutr. 2025 Oct 23;13(10):e71069. [Abstract]
Flow cytometry of apoptosis was applied to detect apoptosis ratio of colorectal cancer cells after being incubated with Phillyrin (0.1, 0.2 mM).
Phillyrin purchased from MedChemExpress. Usage Cited in: Food Sci Nutr. 2025 Oct 23;13(10):e71069. [Abstract]
Wound healing assay demonstrated the effect of Phillyrin (0.1, 0.2 mM) on the migration ability of HT29 and HCT116.
Phillyrin purchased from MedChemExpress. Usage Cited in: Food Sci Nutr. 2025 Oct 23;13(10):e71069. [Abstract]
The western blot analysis revealed a downregulation in the expression of p‐PI3K, p‐AKT, and p‐mTOR in HT29 and HCT116 cells following treatment with Phillyrin (0.1, 0.2 mM).
Phillyrin purchased from MedChemExpress. Usage Cited in: Food Sci Nutr. 2025 Oct 23;13(10):e71069. [Abstract]
Colony formation assays displayed the proliferation of colorectal cancer cells was suppressed by Phillyrin (0.1, 0.2 mM) in a dose‐dependent manner.
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J Orthop Surg Res
Phillyrin reduces ROS production to alleviate the progression of intervertebral disc degeneration by inhibiting NF-κB pathway. [Abstract]2024 May 22;19(1):308. PMID: 38773639 -
Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607
Solvente y solubilidad
DMSO : 250 mg/mL (467.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.17 mg/mL (4.06 mM); Clear solution
This protocol yields a clear solution of ≥ 2.17 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.17 mg/mL (4.06 mM); Clear solution
This protocol yields a clear solution of ≥ 2.17 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.7 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (279 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Cheng Y, et al. Effects of phillyrin and forsythoside A on rat cytochrome P450 activities in vivo and in vitro. Xenobiotica. 2017 Apr;47(4):297-303. [Content Brief]
[2]. Qu XY, et al. Protective effects of phillyrin against influenza A virus in vivo. Arch Pharm Res. 2016 Jul;39(7):998-1005. [Content Brief]
[3]. Do MT, et al. Phillyrin attenuates high glucose-induced lipid accumulation in human HepG2 hepatocytes through the activation of LKB1/AMP-activated protein kinase-dependent signalling. Food Chem. 2013 Jan 15;136(2):415-25. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8707 mL | 9.3537 mL | 18.7073 mL | 46.7683 mL |
| 5 mM | 0.3741 mL | 1.8707 mL | 3.7415 mL | 9.3537 mL | |
| 10 mM | 0.1871 mL | 0.9354 mL | 1.8707 mL | 4.6768 mL | |
| 15 mM | 0.1247 mL | 0.6236 mL | 1.2472 mL | 3.1179 mL | |
| 20 mM | 0.0935 mL | 0.4677 mL | 0.9354 mL | 2.3384 mL | |
| 25 mM | 0.0748 mL | 0.3741 mL | 0.7483 mL | 1.8707 mL | |
| 30 mM | 0.0624 mL | 0.3118 mL | 0.6236 mL | 1.5589 mL | |
| 40 mM | 0.0468 mL | 0.2338 mL | 0.4677 mL | 1.1692 mL | |
| 50 mM | 0.0374 mL | 0.1871 mL | 0.3741 mL | 0.9354 mL | |
| 60 mM | 0.0312 mL | 0.1559 mL | 0.3118 mL | 0.7795 mL | |
| 80 mM | 0.0234 mL | 0.1169 mL | 0.2338 mL | 0.5846 mL | |
| 100 mM | 0.0187 mL | 0.0935 mL | 0.1871 mL | 0.4677 mL |
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