SX-682
Based on 10 publication(s) in Google Scholar
SX-682 is an orally bioavailable, potent allosteric inhibitor of CXCR1 and CXCR2. SX-682 can block tumor myeloid-derived suppressor cells (MDSCs) recruitment and enhance T cell activation and antitumor immunity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.64%
- No. CAS: 1648843-04-2
- Fòrmula: C19H14BF4N3O4S
- Peso molecular:467.20
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
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Publications Citing Use of MedChemExpress (MCE) SX-682
More- Hepatology. 2022 Oct;76(4):967-981. [Abstract]
- Nat Commun. 2025 Feb 17;16(1):1715. [Abstract]
- J Exp Clin Cancer Res. 2024 Mar 19;43(1):86. [Abstract]
- Cancer Lett. 2026 May 1:645:218395. [Abstract]
- Cell Death Dis. 2026 Mar 27. [Abstract]
- Cell Death Dis. 2021 Nov 1;12(11):1038. [Abstract]
- Infect Immun. 2023 Apr 18;91(4):e0001423. [Abstract]
- University of North Carolina. 2025.
- The University of Chicago. 2024 Jun.
- Res Sq. 2024 May 8:rs.3.rs-3243545. [Abstract]
Actividad biológica
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CXCR1 |
CXCR2 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6NTac-Tyrtm1Arte female mice[2]
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Dosage:50 mg/kg
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Administration:Orally; twice a day on a Monday through Friday
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Result:Has Meager to moderate effects on CRPC progression.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 1648843-04-2
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Appearance Solid
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Peso molecular 467.20
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Fòrmula C19H14BF4N3O4S
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Color Off-white to light yellow
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SMILES
O=C(NC1=CC=C(F)C=C1)C(C=N2)=CN=C2SCC3=CC(OC(F)(F)F)=CC=C3B(O)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 1 year -20°C 6 months
Publications (10)
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Journal Impact Factor
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Most Recent
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Hepatology
KIAA1199 drives immune suppression to promote colorectal cancer liver metastasis by modulating neutrophil infiltration. [Abstract]2022 Oct;76(4):967-981. PMID: 35108400 -
Nat Commun
The CXCL8/MAPK/hnRNP-K axis enables susceptibility to infection by EV-D68, rhinovirus, and influenza virus in vitro. [Abstract]2025 Feb 17;16(1):1715. PMID: 39962077 -
J Exp Clin Cancer Res
Unveiling CXCR2 as a promising therapeutic target in renal cell carcinoma: exploring the immunotherapeutic paradigm shift through its inhibition by RCT001. [Abstract]2024 Mar 19;43(1):86. PMID: 38504270 -
Cancer Lett
DysUFMylation reprograms immunosuppressive neutrophils to potentiate anti-PD-1 therapy in hepatocellular carcinoma. [Abstract]2026 May 1:645:218395. PMID: 41780840 -
Cell Death Dis
HIF1 inhibition targets tumoral and myeloid cells, and is a promising therapy for metastatic castration-resistant prostate cancer. [Abstract]2026 Mar 27. PMID: 41896221 -
Cell Death Dis
PERK signaling through C/EBPδ contributes to ER stress-induced expression of immunomodulatory and tumor promoting chemokines by cancer cells. [Abstract]2021 Nov 1;12(11):1038. PMID: 34725321 -
Infect Immun
Staphylococcus aureus Infection Induces the Production of the Neutrophil Chemoattractants CXCL1, CXCL2, CXCL3, CXCL5, CCL3, and CCL7 by Murine Osteoblasts. [Abstract]2023 Apr 18;91(4):e0001423. PMID: 36880752 -
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Res Sq
Programable Albumin-Hitchhiking Nanobodies Enhance the Delivery of STING Agonists to Potentiate Cancer Immunotherapy. [Abstract]2024 May 8:rs.3.rs-3243545. PMID: 38766114
Solvente y solubilidad
DMSO : 100 mg/mL (214.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (10.70 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 15% Cremophor EL 85% Saline
Solubility: 11.76 mg/mL (25.17 mM); Suspended solution; Need ultrasonic and warming and heat to 60°C
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Sun L, et al. Inhibiting myeloid-derived suppressor cell trafficking enhances T cell immunotherapy. JCI Insight. 2019 Apr 4;4(7). [Content Brief]
[2]. Lu X, et al. Effective combinatorial immunotherapy for castration-resistant prostate cancer. Nature. 2017 Mar 30;543(7647):728-732. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1404 mL | 10.7021 mL | 21.4041 mL | 53.5103 mL |
| 5 mM | 0.4281 mL | 2.1404 mL | 4.2808 mL | 10.7021 mL | |
| 10 mM | 0.2140 mL | 1.0702 mL | 2.1404 mL | 5.3510 mL | |
| 15 mM | 0.1427 mL | 0.7135 mL | 1.4269 mL | 3.5674 mL | |
| 20 mM | 0.1070 mL | 0.5351 mL | 1.0702 mL | 2.6755 mL | |
| 25 mM | 0.0856 mL | 0.4281 mL | 0.8562 mL | 2.1404 mL | |
| 30 mM | 0.0713 mL | 0.3567 mL | 0.7135 mL | 1.7837 mL | |
| 40 mM | 0.0535 mL | 0.2676 mL | 0.5351 mL | 1.3378 mL | |
| 50 mM | 0.0428 mL | 0.2140 mL | 0.4281 mL | 1.0702 mL | |
| 60 mM | 0.0357 mL | 0.1784 mL | 0.3567 mL | 0.8918 mL | |
| 80 mM | 0.0268 mL | 0.1338 mL | 0.2676 mL | 0.6689 mL | |
| 100 mM | 0.0214 mL | 0.1070 mL | 0.2140 mL | 0.5351 mL |
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