Thiothixene
Thiothixene is a typical antipsychotic. It selectively binds to dopamine D2 over D1, D3, and D4 receptors (Kis=0.417, 338, 186.2, and 363.1 nM, respectively). Thiothixene also binds to various serotonin (5-HT), histamine H1, α1- and α2-adrenergic, muscarinic acetylcholine, and sigma receptors (Kis=15-5,754 nM) as well as the dopamine, norepinephrine, and serotonin transporters (Kis=3.16-30 μM). In vivo, thiothixene reduces spontaneous and amphetamine-induced locomotor activity in rats. It enhances latent inhibition, as measured by a decreased lick latency in response to light and foot shock stimuli, which is a measure of selective attention in rats.3 Thiothixene also increases competitive behavior in submissive mice, indicating antidepressant-like behavior.
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- No. CAS: 5591-45-7
- Fòrmula: C23H29N3O2S2
- Peso molecular:443.63
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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HY-10121
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HY-103093
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HY-17407
Ziprasidone hydrochloride monohydrate5-HT/DA Receptor Antagonist -
HY-10121R
Asenapine (Standard)5-HT/Dopamine/Histamine/Adrenergic Receptors Antagonist -
HY-103093R
Zotepine (Standard)Antipsychotic Agent -
HY-17407R
Ziprasidone hydrochloride monohydrate (Standard)5-HT/DA Receptor Antagonist
Ver todos los productos específicos de isoformas Sigma Receptor
MoreVer todos los productos específicos de isoformas Dopamine Receptor
MoreVer todos los productos específicos de isoformas Histamine Receptor
MoreVer todos los productos específicos de isoformas Adrenergic Receptor
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Actividad biológica
Descripciòn
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 5591-45-7
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Peso molecular 443.63
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Fòrmula C23H29N3O2S2
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SMILES
O=S(C1=CC(/C2=C/CCN3CCN(C)CC3)=C(SC4=C2C=CC=C4)C=C1)(N(C)C)=O
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Synonyms
NSC 108165; Navan; Navane
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Protocol for Open Field Test (OF)
The Open Field Test is a rodent behavioral assay that measures spontaneous locomotion, exploratory behavior, and anxiety-like behavior when an animal is placed in a novel open arena. The main readouts are total distance traveled, movement time, velocity, center-zone entries, center-zone time, peripheral-zone time, and thigmotaxis. The assay is based on the conflict between exploration of a novel environment and avoidance of exposed open areas; higher center exploration is commonly interpreted as lower anxiety-like behavior, whereas increased wall-following or peripheral occupancy is interpreted as higher anxiety-like behavior.
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Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Thiothixene Related Classifications
HY-A0139 Related Classifications
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