UNC9750
UNC9750 is an inositol phosphate multikinase (IPMK) inhibitor with IC50 values of 31.6 and 374 nM for IPMK and IP6K2, respectively.. UNC9750 inhibits cellular accumulation of InsP5, the direct product of IPMK kinase activity, while having no effect on either InsP6 or InsP7 levels. UNC9750 has ≥ 75% inhibition of four kinases (DAPK1, DYRK1B, PDGFR, and KDR). UNC9750 can be used for the study of glioblastoma.
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- No. CAS: 2967648-29-7
- Fòrmula: C23H24N6O
- Peso molecular:400.48
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
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DYRK1B |
DAPK1 |
PDGFR |
PDGFR2 |
UNC9750 (Compound 14) (0-10 μM, 48-72 h) decreases human glioblastoma cell U251-MG growth and selectively reduces cellular InsP5 abundance but does not decrease InsP6 or InsP7 levels after 72 h[1].
UNC9750 (1 μM) has ≥ 75% inhibition of four kinases (DAPK1, DYRK1B, PDGFR, and KDR[1].
UNC9750 (10-50 μM, 24 h) can significantly and concentration-dependently upregulate the expression of SF-1 target gene CYP11A1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | T1/2 | Cmax | AUClast | Vss | CL |
|---|---|---|---|---|---|---|---|
| Mice[1] | 2.75 mg/kg | i.v. | 1.95 h | 28.3 μM | 4.6 μM·h | 0.39 L/kg | 22.8 mL/min/kg |
Chemical Information
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No. CAS 2967648-29-7
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Peso molecular 400.48
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Fòrmula C23H24N6O
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SMILES
C1(C2=NN=NN2)=CC3=C(ON=C3C=C1)C4=CC(C5CCN(CC5)C6CCC6)=CC=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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