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CDR2 - cerebellar degeneration related protein 2 Gene

Also Known as Yo; CDR62

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1039

About CDR2

Cytogenetic location: 16p12.2 Genomic coordinates (GRCh38): 16:22,345,936-22,374,619 (from NCBI)

This gene has 7 transcripts (splice variants), 274 orthologues and 1 paralogue. Broad expression in testis (RPKM 38.3), thyroid (RPKM 28.3) and 24 other tissues.

Summary

Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CDR2 Products (1)

mRNA	Protein	Name
NM_001802.2	NP_001793.1	cerebellar degeneration-related protein 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11988016	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cerebellar degeneration-related protein 2	Yo paraneoplastic antigen

CDR2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDR2	Q01850	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	25416956
Intra	CDR2	Q01850	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	32296183
Intra	CDR2	Q01850	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Array	25416956
Intra	CDR2	Q01850	CEP57L1	Homo sapiens	Q8IYX8-2	Y2H Array	25416956
Intra	CDR2	Q01850	CEP57L1	Homo sapiens	Q8IYX8-2	Y2H Prey Pooling	25416956
Intra	CDR2	Q01850	ZGPAT	Homo sapiens	Q8N5A5-2	Validated Y2H	32296183
Intra	CDR2	Q01850	AMOTL2	Homo sapiens	Q9Y2J4-4	Y2H Prey Pooling	25416956
Intra	CDR2	Q01850	PDZD4	Homo sapiens	Q17RL8	Validated Y2H	32296183
Intra	CDR2	Q01850	TSGA10IP	Homo sapiens	Q3SY00	Validated Y2H	32296183
Intra	CDR2	Q01850	DRC12	Homo sapiens	Q494R4	Y2H Prey Pooling	25416956
Intra	CDR2	Q01850	DRC12	Homo sapiens	Q494R4	Y2H Array	25416956
Intra	CDR2	Q01850	SH2D4A	Homo sapiens	Q9H788-2	Y2H Array	25416956
Intra	CDR2	Q01850	SH2D4A	Homo sapiens	Q9H788-2	Validated Y2H	25416956
Intra	CDR2	Q01850	COX5B	Homo sapiens	P10606	Y2H Array	31515488
Intra	CDR2	Q01850	COX5B	Homo sapiens	P10606	Y2H Array	25416956
Intra	CDR2	Q01850	CCDC146	Homo sapiens	Q8IYE0	Validated Y2H	32296183
Intra	CDR2	Q01850	CCDC13	Homo sapiens	Q8IYE1	Validated Y2H	32296183
Intra	CDR2	Q01850	TRIML2	Homo sapiens	Q8N7C3	Validated Y2H	32296183
Intra	CDR2	Q01850	TRIML2	Homo sapiens	Q8N7C3	Y2H Array	32296183
Intra	CDR2	Q01850	CDR2L	Homo sapiens	Q86X02	Anti Tag CoIP	33961781
Intra	CDR2	Q01850	CDR2L	Homo sapiens	Q86X02	TAP	27173435
Intra	CDR2	Q01850	CDR2L	Homo sapiens	Q86X02	Anti Tag CoIP	28514442
Intra	CDR2	Q01850	CDR2L	Homo sapiens	Q86X02	Validated Y2H	32296183
Intra	CDR2	Q01850	DRC12	Homo sapiens	Q494R4-2	Validated Y2H	32296183
Intra	CDR2	Q01850	RUNX1T1	Homo sapiens	Q06455-2	Validated Y2H	32296183
Intra	CDR2	Q01850	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	CDR2	Q01850	MGC50722	Homo sapiens	Q8IVT4	Validated Y2H	32296183
Intra	CDR2	Q01850	FAM110A	Homo sapiens	Q9BQ89	Y2H Prey Pooling	25416956
Intra	CDR2	Q01850	KIFC3	Homo sapiens	Q9BVG8	Y2H Prey Pooling	25416956
Intra	CDR2	Q01850	ZMAT2	Homo sapiens	Q96NC0	Validated Y2H	32296183
Intra	CDR2	Q01850	PRPF18	Homo sapiens	Q99633	Validated Y2H	32296183
Intra	CDR2	Q01850	HDAC4	Homo sapiens	P56524	Y2H Prey Pooling	25416956
Intra	CDR2	Q01850	HDAC4	Homo sapiens	P56524	Validated Y2H	25416956
Intra	CDR2	Q01850	SMARCD1	Homo sapiens	Q96GM5	Validated Y2H	32296183
Intra	CDR2	Q01850	TXLNA	Homo sapiens	P40222	Y2H Array	31515488
Intra	CDR2	Q01850	TXLNA	Homo sapiens	P40222	Validated Y2H	25416956
Intra	CDR2	Q01850	TXLNA	Homo sapiens	P40222	Y2H Prey Pooling	25416956
Intra	CDR2	Q01850	TXLNA	Homo sapiens	P40222	Y2H Array	25416956
Intra	CDR2	Q01850	EIF4E2	Homo sapiens	O60573	Y2H Prey Pooling	25416956
Intra	CDR2	Q01850	MORF4L2	Homo sapiens	Q15014	Y2H	11988016
Intra	CDR2	Q01850	MORF4L2	Homo sapiens	Q15014	IF	11988016
Intra	CDR2	Q01850	MORF4L2	Homo sapiens	Q15014	Anti Tag CoIP	11988016
Intra	CDR2	Q01850	MORF4L2	Homo sapiens	Q15014	Far-WB	11988016
Intra	CDR2	Q01850	SMARCE1	Homo sapiens	Q969G3	Validated Y2H	32296183
Intra	CDR2	Q01850	PKN1	Homo sapiens	Q16512	Validated Y2H	32296183
Intra	CDR2	Q01850	TXLNB	Homo sapiens	Q8N3L3	Validated Y2H	32296183
Intra	CDR2	Q01850	C4orf46	Homo sapiens	Q504U0	Validated Y2H	32296183
Intra	CDR2	Q01850	C4orf46	Homo sapiens	Q504U0	Anti Tag CoIP	33961781
Intra	CDR2	Q01850	C4orf46	Homo sapiens	Q504U0	Anti Tag CoIP	28514442
Intra	CDR2	Q01850	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	32296183
Intra	CDR2	Q01850	TTR	Homo sapiens	P02766	Y2H Prey Pooling	25416956
Intra	CDR2	Q01850	TTR	Homo sapiens	P02766	Y2H Array	25416956
Intra	CDR2	Q01850	INO80B	Homo sapiens	Q9C086	Validated Y2H	32296183
Intra	CDR2	Q01850	FAM161A	Homo sapiens	Q3B820	Validated Y2H	25416956
Intra	CDR2	Q01850	FAM161A	Homo sapiens	Q3B820	Validated Y2H	32296183
Intra	CDR2	Q01850	MKKS	Homo sapiens	Q9NPJ1	Validated Y2H	32296183
Intra	CDR2	Q01850	FAM161B	Homo sapiens	Q96MY7	Validated Y2H	32296183
Intra	CDR2	Q01850	MRPL28	Homo sapiens	Q13084	Validated Y2H	25416956
Intra	CDR2	Q01850	MRPL28	Homo sapiens	Q13084	Y2H Prey Pooling	25416956
Intra	CDR2	Q01850	LENG1	Homo sapiens	Q96BZ8	Validated Y2H	32296183
Intra	CDR2	Q01850	LENG1	Homo sapiens	Q96BZ8	Y2H Prey Pooling	25416956
Intra	CDR2	Q01850	C2CD6	Homo sapiens	Q53TS8	Y2H Prey Pooling	25416956
Intra	CDR2	Q01850	C2CD6	Homo sapiens	Q53TS8	Y2H Array	25416956
Intra	CDR2	Q01850	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	25416956
Intra	CDR2	Q01850	TRIM23	Homo sapiens	P36406	Validated Y2H	25416956
Intra	CDR2	Q01850	TRIM23	Homo sapiens	P36406	Y2H Array	25416956
Intra	CDR2	Q01850	KANSL1	Homo sapiens	Q7Z3B3	Y2H Array	31515488
Intra	CDR2	Q01850	KANSL1	Homo sapiens	Q7Z3B3	Validated Y2H	25416956
Intra	CDR2	Q01850	KANSL1	Homo sapiens	Q7Z3B3	Y2H Array	25416956
Intra	CDR2	Q01850	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	32296183
Intra	CDR2	Q01850	TCHP	Homo sapiens	Q9BT92	MAPPIT	32296183
Intra	CDR2	Q01850	TCHP	Homo sapiens	Q9BT92	Y2H Array	31515488
Intra	CDR2	Q01850	TCHP	Homo sapiens	Q9BT92	Y2H Prey Pooling	25416956
Intra	CDR2	Q01850	TCHP	Homo sapiens	Q9BT92	Validated Y2H	32296183
Intra	CDR2	Q01850	TCHP	Homo sapiens	Q9BT92	Y2H Array	25416956
Intra	CDR2	Q01850	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	31515488
Intra	CDR2	Q01850	NTAQ1	Homo sapiens	Q96HA8	Y2H Prey Pooling	25416956
Intra	CDR2	Q01850	CHIC2	Homo sapiens	Q9UKJ5	Validated Y2H	32296183
Intra	CDR2	Q01850	CHIC2	Homo sapiens	Q9UKJ5	Y2H Array	25416956
Intra	CDR2	Q01850	FAM50B	Homo sapiens	Q9Y247	Validated Y2H	32296183
Intra	CDR2	Q01850	RCOR3	Homo sapiens	Q9P2K3	Validated Y2H	25416956
Intra	CDR2	Q01850	MNS1	Homo sapiens	Q8NEH6	Validated Y2H	32296183
Intra	CDR2	Q01850	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	25416956
Intra	CDR2	Q01850	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	CDR2	Q01850	ENKD1	Homo sapiens	Q9H0I2	Y2H Array	25416956
Intra	CDR2	Q01850	CCDC120	Homo sapiens	Q96HB5	Validated Y2H	32296183
Intra	CDR2	Q01850	ANKRD36BP1	Homo sapiens	Q96IX9	Y2H Prey Pooling	25416956
Intra	CDR2	Q01850	ANKRD36BP1	Homo sapiens	Q96IX9	Validated Y2H	25416956
Intra	CDR2	Q01850	ANKRD36BP1	Homo sapiens	Q96IX9	Y2H Array	25416956
Intra	CDR2	Q01850	BEX2	Homo sapiens	Q9BXY8	Validated Y2H	32296183
Intra	CDR2	Q01850	CDK18	Homo sapiens	Q07002	Validated Y2H	32296183
Intra	CDR2	Q01850	SH2D4A	Homo sapiens	Q9H788	Validated Y2H	32296183
Intra	CDR2	Q01850	SH2D4A	Homo sapiens	Q9H788	Y2H Array	25416956
Intra	CDR2	Q01850	SH2D4A	Homo sapiens	Q9H788	Y2H Prey Pooling	25416956
Intra	CDR2	Q01850	C1orf216	Homo sapiens	Q8TAB5	Validated Y2H	32296183
Intra	CDR2	Q01850	TEAD4	Homo sapiens	Q15561	Validated Y2H	32296183
Intra	CDR2	Q01850	RSPH14	Homo sapiens	Q9UHP6	Y2H Array	25416956
Intra	CDR2	Q01850	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
Intra	CDR2	Q01850	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	25416956
Intra	CDR2	Q01850	SCNM1	Homo sapiens	Q9BWG6	Y2H Array	25416956
Intra	CDR2	Q01850	LIN37	Homo sapiens	Q96GY3	Validated Y2H	25416956
Intra	CDR2	Q01850	LIN37	Homo sapiens	Q96GY3	Y2H Prey Pooling	25416956
Intra	CDR2	Q01850	CCDC87	Homo sapiens	Q9NVE4	Validated Y2H	32296183
Intra	CDR2	Q01850	TBC1D22B	Homo sapiens	Q9NU19	Validated Y2H	25416956
Intra	CDR2	Q01850	TBC1D22B	Homo sapiens	Q9NU19	Y2H Array	29892012
Intra	CDR2	Q01850	TTC23	Homo sapiens	Q5W5X9-3	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CDR2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72127	CDR2 Protein, Human (His)	Q01850 (M1-S454)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Cerebellar Degeneration
Paraneoplastic Cerebellar Degeneration	Pcd Paraneoplastic Cerebellar Ataxia Rapidely Progressive Cerebellar Syndrome Subacute Cerebellar Degeneration
Anosognosia
Phenytoin Allergy	Dilantin Allergy
Acute Diffuse Nephritis	Acute Diffuse Glomerulonephritis
Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency	Congenital Myasthenic Syndrome 9 CMS9 Congenital Myasthenic Syndrome 9, Associated With Acetylcholine Receptor Deficiency Myasthenic Syndrome, Congenital, Type 9, Associated With Acetylcholine Receptor Deficiency
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145814	HSP90-IN-9	Inhibitor	/	Unkown
HY-RS02423	CDR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02424	CDR2L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20258	Cdr2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22428	Cdr2l Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26766	Cdr2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28951	Cdr2l Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CDR2	VGNC	VGNC:60717
Mus musculus	CDR2	MGD	MGI:1100885
Rattus norvegicus	CDR2	RGD	RGD:1310578
Bos taurus	CDR2	VGNC	VGNC:27153
Macaca mulatta	CDR2	VGNC	VGNC:70993
Canis familiaris	CDR2	VGNC	VGNC:39078
Others	CDR2	NCBI