Abl1 - c-abl oncogene 1, non-receptor tyrosine kinase Gene

Mus musculus

Also known as Abl; c-Abl; E430008G22Rik

Gene ID: 11350 | Gene type: protein coding

About Abl1

Chromosome 2: 31,578,388-31,694,239 forward strand.GRCm39:CM000995.3

This gene has 10 transcripts (splice variants), 204 orthologues, 32 paralogues and is associated with 66 phenotypes. Ubiquitous expression in ovary adult (RPKM 24.4), limb E14.5 (RPKM 24.2) and 28 other tissues.

Summary

Enables several functions, including ATP binding activity; metal ion binding activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of long-term synaptic potentiation; positive regulation of blood vessel branching; and positive regulation of cell migration involved in sprouting angiogenesis. Acts upstream of or within several processes, including cell surface receptor signaling pathway; hematopoietic or lymphoid organ development; and regulation of signal transduction. Located in several cellular components, including actin cytoskeleton; cell leading edge; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in gastrointestinal system Cancer (multiple); leukemia (multiple); and lung non-small cell carcinoma. Orthologous to human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Abl1 Products(5)

mRNA	Protein	Name
NM_001283045.1	NP_001269974.1	tyrosine-protein kinase ABL1 isoform c
NM_001283046.1	NP_001269975.1	tyrosine-protein kinase ABL1 isoform d
NM_001283047.1	NP_001269976.1	tyrosine-protein kinase ABL1 isoform e
NM_001112703.2	NP_001106174.1	tyrosine-protein kinase ABL1 isoform a
NM_009594.4	NP_033724.2	tyrosine-protein kinase ABL1 isoform b

Abl1 Protein Structure

SH3_Abl

SH2_ABL

PTKc_Abl

FABD

0
200
400
600
800
1000
1123 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein kinase ABL1

Abelson murine leukemia oncogene	Abelson tyrosine-protein kinase 1
abelson murine leukemia viral oncogene homolog 1	c-abl oncogene 1, receptor tyrosine kinase
c-abl protein, type I	c-abl protein, type II
c-abl protein, type III	p150
proto-oncogene c-Abl	proto-oncogene tyrosine-protein kinase ABL1
v-abl Abelson murine leukemia oncogene 1

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-104010	Asciminib	Inhibitor	99.88%	Yes
HY-15728	Radotinib		98.92%	Yes
HY-104010A	Asciminib hydrochloride	Inhibitor	99.93%	Yes

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13024	Rebastinib		99.91%	Phase 2
HY-137460	Vodobatinib	Inhibitor	99.85%	Phase 2
HY-13072	Cenisertib	Inhibitor	99.64%	Phase 1

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101763A	(S,R,S)-AHPC monohydrochloride		99.54%	Unkown
HY-125845	(S,R,S)-AHPC		99.13%	Unkown
HY-125834	GMB-475		98.98%	Unkown
HY-148794	Risvodetinib	Inhibitor	99.21%	Unkown
HY-103032	Multi-kinase inhibitor 1	Inhibitor	99.34%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-110402	(S,R,S)-AHPC TFA		/	Unkown
HY-107447S	N-Deshydroxyethyl Dasatinib-d8		/	Unkown
HY-101763B	(S,R,S)-AHPC dihydrochloride		/	Unkown
HY-130297	PROTAC BCR-ABL1 ligand 1	Inhibitor	/	Unkown
HY-145887	BCR-ABL1-IN-1		/	Unkown
HY-14979A	ML786 dihydrochloride	Inhibitor	/	Unkown
HY-155112	Antiproliferative agent-30	Inhibitor	/	Unkown
HY-18819	BCR-ABL-IN-2	Inhibitor	/	Unkown
HY-RS00102	ABL1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS00103	Abl1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS00104	ABL1 Rat Pre-designed siRNA Set A		/	Unkown
HY-12338	ON 146040	Inhibitor	95.05%	Unkown
HY-101268	CHMFL-ABL-053		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Abl1	NCBI	NCBI:25

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