Cav1 - caveolin 1, caveolae protein Gene

Also Known as Cav; Cav-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12389

Summary

Enables several functions, including enzyme binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in several processes, including negative regulation of programmed cell death; negative regulation of protein modification process; and regulation of gene expression. Acts upstream of with a negative effect on lactation. Acts upstream of or within several processes, including blood vessel diameter maintenance; blood vessel morphogenesis; and negative regulation of signal transduction. Located in several cellular components, including acrosomal membrane; caveola; and perinuclear region of cytoplasm. Is integral component of plasma membrane. Part of caveolar macromolecular signaling complex. Colocalizes with focal adhesion. Is expressed in several structures, including cardiovascular system; cerebral cortex; intestine smooth muscle circular layer; lung; and paraxial mesenchyme. Used to study Alzheimer's disease; breast cancer; and hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in several diseases, including breast Cancer (multiple); lipodystrophy (multiple); primary open angle glaucoma; primary pulmonary hypertension; and systemic scleroderma (multiple). Orthologous to human CAV1 (caveolin 1). [provided by Alliance of Genome Resources, Apr 2022]

Cav1 Products (14)

mRNA	Protein	Name
NM_001243064.2	NP_001229993.1	caveolin-1 isoform 2
NM_001409558.1	NP_001396487.1	caveolin-1 isoform 1
NM_001409559.1	NP_001396488.1	caveolin-1 isoform 2
NM_001409560.1	NP_001396489.1	caveolin-1 isoform 2
NM_001409561.1	NP_001396490.1	caveolin-1 isoform 2
NM_001409562.1	NP_001396491.1	caveolin-1 isoform 2
NM_001409563.1	NP_001396492.1	caveolin-1 isoform 2
NM_001409564.1	NP_001396493.1	caveolin-1 isoform 3
NM_001409565.1	NP_001396494.1	caveolin-1 isoform 4
NM_001409566.1	NP_001396495.1	caveolin-1 isoform 5
NM_001409567.1	NP_001396496.1	caveolin-1 isoform 5
NM_001409568.1	NP_001396497.1	caveolin-1 isoform 6
NM_001409569.1	NP_001396498.1	caveolin-1 isoform 6
NM_007616.5	NP_031642.1	caveolin-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	8552590	MGI
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	25017399	MGI
enables nitric-oxide synthase binding	IPI IPI: Inferred from physical interaction	25017399	MGI
enables oxysterol binding	IMP IMP: Inferred from mutant phenotype	34799735	MGI
enables peptidase activator activity	IMP IMP: Inferred from mutant phenotype	17349656	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11956154	MGI
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	9361015	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	25017399	MGI
enables protein tyrosine kinase inhibitor activity	IMP IMP: Inferred from mutant phenotype	25017399	MGI
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	25017399	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of MAPK cascade	IMP IMP: Inferred from mutant phenotype	12388746	MGI
acts upstream of or within angiogenesis	IGI IGI: Inferred from genetic interaction	12759260	MGI
involved in angiotensin-activated signaling pathway	IGI IGI: Inferred from genetic interaction	25017399	MGI
acts upstream of or within basement membrane organization	IMP IMP: Inferred from mutant phenotype	11884617	MGI
acts upstream of or within calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	12651616	MGI
acts upstream of or within calcium ion transport	IMP IMP: Inferred from mutant phenotype	17416589	MGI
acts upstream of or within caveola assembly	IDA IDA: Inferred from direct assay	11884617	MGI
involved in caveola assembly	IGI IGI: Inferred from genetic interaction	25006397	MGI
acts upstream of or within caveola assembly	IMP IMP: Inferred from mutant phenotype	12759260	MGI
acts upstream of or within caveolin-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	17715130	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12388077	MGI
involved in cellular response to peptide hormone stimulus	IGI IGI: Inferred from genetic interaction	25017399	MGI
acts upstream of or within cellular response to transforming growth factor beta stimulus	IMP IMP: Inferred from mutant phenotype	21829547	MGI
acts upstream of or within cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	16603689	MGI
acts upstream of cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	12388746	MGI
acts upstream of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	11884617	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	17416589	MGI
acts upstream of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	12388077	MGI
acts upstream of glandular epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	12388746	MGI
involved in insulin receptor internalization	IMP IMP: Inferred from mutant phenotype	27110488	MGI
acts upstream of or within intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	17098833	MGI
acts upstream of or within intracellular nitric oxide homeostasis	IMP IMP: Inferred from mutant phenotype	12177436	MGI
acts upstream of negative effect lactation	IMP IMP: Inferred from mutant phenotype	12388746	MGI
acts upstream of or within lipid storage	IMP IMP: Inferred from mutant phenotype	11884617	MGI
acts upstream of or within mammary gland development	IMP IMP: Inferred from mutant phenotype	12388746	MGI
acts upstream of or within mammary gland involution	IMP IMP: Inferred from mutant phenotype	12388746	MGI
acts upstream of or within membrane depolarization	IMP IMP: Inferred from mutant phenotype	17098833	MGI
acts upstream of or within muscle cell cellular homeostasis	IMP IMP: Inferred from mutant phenotype	17098833	MGI
acts upstream of or within negative regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	12388746	MGI
acts upstream of or within negative regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	12388077	MGI
involved in negative regulation of anoikis	IMP IMP: Inferred from mutant phenotype	22277751	MGI
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	10816572	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17202321	MGI
acts upstream of or within negative regulation of cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	12388746	MGI
acts upstream of or within negative regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	11884617	MGI
acts upstream of or within negative regulation of epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	12388746	MGI
acts upstream of or within negative regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	12388077	MGI
involved in negative regulation of necroptotic process	IMP IMP: Inferred from mutant phenotype	23049990	MGI
acts upstream of or within negative regulation of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	12388077	MGI
acts upstream of or within negative regulation of nitric-oxide synthase activity	IMP IMP: Inferred from mutant phenotype	16380094	MGI
involved in negative regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	22277751	MGI
acts upstream of or within negative regulation of receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	12388746	MGI
acts upstream of or within negative regulation of receptor signaling pathway via JAK-STAT	IGI IGI: Inferred from genetic interaction	12388746	MGI
acts upstream of or within negative regulation of receptor signaling pathway via JAK-STAT	IMP IMP: Inferred from mutant phenotype	12388746	MGI
acts upstream of or within negative regulation of signal transduction	IDA IDA: Inferred from direct assay	9685399	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10816572	MGI
acts upstream of or within negative regulation of tyrosine phosphorylation of STAT protein	IDA IDA: Inferred from direct assay	12388746	MGI
acts upstream of or within negative regulation of tyrosine phosphorylation of STAT protein	IMP IMP: Inferred from mutant phenotype	12388746	MGI
acts upstream of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	12388077	MGI
involved in positive regulation of calcium ion transport into cytosol	IDA IDA: Inferred from direct assay	19052258	MGI
acts upstream of or within positive regulation of catalytic activity	IMP IMP: Inferred from mutant phenotype	17349656	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	15734843	MGI
involved in positive regulation of gap junction assembly	IMP IMP: Inferred from mutant phenotype	25017399	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25017399	MGI
acts upstream of or within positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	11884617	MGI
involved in post-transcriptional regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25017399	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	17416589	MGI
acts upstream of or within protein transport	IMP IMP: Inferred from mutant phenotype	17715130	MGI
involved in regulation of cell communication by electrical coupling involved in cardiac conduction	IMP IMP: Inferred from mutant phenotype	25017399	MGI
acts upstream of or within regulation of fatty acid metabolic process	IMP IMP: Inferred from mutant phenotype	11884617	MGI
involved in regulation of heart rate by cardiac conduction	IMP IMP: Inferred from mutant phenotype	25017399	MGI
acts upstream of or within regulation of peptidase activity	IMP IMP: Inferred from mutant phenotype	17349656	MGI
acts upstream of or within regulation of smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	16782699	MGI
acts upstream of or within regulation of the force of heart contraction	IMP IMP: Inferred from mutant phenotype	16380094	MGI
acts upstream of or within regulation of the force of heart contraction by chemical signal	IGI IGI: Inferred from genetic interaction	18951881	MGI
involved in regulation of ventricular cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	25017399	MGI
involved in response to calcium ion	IDA IDA: Inferred from direct assay	19052258	MGI
acts upstream of or within response to estrogen	IDA IDA: Inferred from direct assay	12388746	MGI
acts upstream of or within response to hypoxia	IMP IMP: Inferred from mutant phenotype	16601228	MGI
acts upstream of or within response to ischemia	IMP IMP: Inferred from mutant phenotype	17293479	MGI
acts upstream of or within skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	17200204	MGI
acts upstream of or within triglyceride metabolic process	IMP IMP: Inferred from mutant phenotype	11884617	MGI
acts upstream of tyrosine phosphorylation of STAT protein	IMP IMP: Inferred from mutant phenotype	12388746	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	16601228	MGI
acts upstream of or within vasoconstriction	IMP IMP: Inferred from mutant phenotype	17098833	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	10787428	MGI
located in acrosomal membrane	IDA IDA: Inferred from direct assay	11784086	MGI
located in caveola	IDA IDA: Inferred from direct assay	8552590	MGI
part of caveolar macromolecular signaling complex	IDA IDA: Inferred from direct assay	11884617	MGI
located in cell cortex	IDA IDA: Inferred from direct assay	10631317	MGI
located in cilium	IDA IDA: Inferred from direct assay	11784086	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	10787428	MGI
colocalizes with focal adhesion	IDA IDA: Inferred from direct assay	12091389	MGI
located in membrane	IDA IDA: Inferred from direct assay	10460238	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	10197531	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	8552590	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	8552590	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	25017399	MGI
part of protein-containing complex	IPI IPI: Inferred from physical interaction	17416589	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
caveolin-1	caveolin, caveolae protein 1 caveolin, caveolae protein, 22 kDa

Cav1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Cav1	P49817	MCL1	Homo sapiens	Q07820	Anti Bait CoIP	22277751
Cross	Cav1	P49817	MCL1	Homo sapiens	Q07820	Confocal	22277751
Cross	Cav1	P49817	SCP2	Homo sapiens	P22307	Anti Bait CoIP	15182174
Cross	Cav1	P49817	SCP2	Homo sapiens	P22307	EM	15182174

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1090	Cinnarizine	Inhibitor	99.56%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112499	Menaquinone-7	Activator	98.51%	Phase 2
HY-112499R	Menaquinone-7 (Standard)		98.27%	Phase 2

Pre-clinical Phase

Bioactive Molecules (32)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134542	CaV1.3 antagonist-1	Antagonist	98.38%	Unkown
HY-N2488	Demethylsuberosin	Inhibitor	99.71%	Unkown
HY-RS01986	CAV1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-B1752	Quinpirole		98.95%	Unkown
HY-106454	N-Desalkylflurazepam	Inhibitor	99.95%	Unkown
HY-RS17533	Cav1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-Z15823	(R)-Verapamil		98.97%	Unkown
HY-118202	(-)-Gallopamil	Inhibitor	/	Unkown
HY-118202A	(-)-Gallopamil hydrochloride	Inhibitor	/	Unkown
HY-126336	HM12	Inhibitor	/	Unkown
HY-146173	KCa1.1 channel activator-1		/	Unkown
HY-159090	AT1R antagonist 3		/	Unkown
HY-17402S	Nisoldipine-d6	Inhibitor	/	Unkown
HY-17402S3	Nisoldipine-d3	Inhibitor	/	Unkown
HY-175395	Onychocin B	Inhibitor	/	Unkown
HY-180547	MRC71		/	Unkown
HY-181755	Phenylaminojuglone AJ-2	Inhibitor	/	Unkown
HY-184190	ERG-IN-7	Inhibitor	/	Unkown
HY-184501	UE01		/	Unkown
HY-N12859	Herbacetin 3-O-glucopyranoside-8-O-glucuronopyranoside		/	Unkown
HY-P3269A	Calciseptine TFA	Inhibitor	97.55%	Unkown
HY-W701464	N-Desalkylflurazepam-d4		/	Unkown
HY-Z7760	Felodipine 3,5-dimethyl ester	Modulator	/	Unkown
HY-116307	2-Thio-UTP	Agonist	/	Unkown
HY-122552	Chrysotobibenzyl	Inhibitor	/	Unkown
HY-156889	Cav 3.1 blocker 1	Antagonist	/	Unkown
HY-17402S1	Nisoldipine-d4	Inhibitor	/	Unkown
HY-17402S2	Nisoldipine-d7	Inhibitor	/	Unkown
HY-175226	DPP8/9-IN-2	Inhibitor	/	Unkown
HY-N4189	Isocucurbitacin B		98.98%	Unkown
HY-P3269	Calciseptine	Inhibitor	/	Unkown
HY-RS23990	Cav1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cav1	NCBI	NCBI:857