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Cd36 - CD36 molecule Gene

Also Known as FAT; GPIV; Scarb3

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12491

Summary

Enables lipoprotein particle binding activity; lipoteichoic acid immune receptor activity; and low-density lipoprotein particle receptor activity. Involved in several processes, including lipid transport; regulation of gene expression; and regulation of Reactive Oxygen Species metabolic process. Acts upstream of or within several processes, including phagocytosis; positive regulation of cytokine production; and response to bacterium. Located in several cellular components, including brush border membrane; external side of plasma membrane; and membrane raft. Is expressed in several structures, including Meckel's cartilage; axial skeleton; bone; hindlimb; and telencephalon. Used to study platelet-type bleeding disorder 10. Human ortholog(s) of this gene implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human CD36 (CD36 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd36 Products (5)

mRNA	Protein	Name
NM_001159555.1	NP_001153027.1	platelet glycoprotein 4
NM_001159556.1	NP_001153028.1	platelet glycoprotein 4
NM_001159557.1	NP_001153029.1	platelet glycoprotein 4
NM_001159558.1	NP_001153030.1	platelet glycoprotein 4
NM_007643.4	NP_031669.3	platelet glycoprotein 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables high-density lipoprotein particle binding	IDA IDA: Inferred from direct assay	14729860	MGI
enables lipoteichoic acid immune receptor activity	IMP IMP: Inferred from mutant phenotype	16061696	MGI
enables low-density lipoprotein particle binding	IMP IMP: Inferred from mutant phenotype	10772654	MGI
enables low-density lipoprotein particle receptor activity	IMP IMP: Inferred from mutant phenotype	10772654	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15748999	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of MAPK cascade	IMP IMP: Inferred from mutant phenotype	15690042	MGI
involved in amyloid fibril formation	IDA IDA: Inferred from direct assay	23812099	MGI
acts upstream of or within apoptotic cell clearance	IMP IMP: Inferred from mutant phenotype	15647754	MGI
involved in cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	20978343	MGI
acts upstream of or within cellular response to bacterial lipopeptide	IMP IMP: Inferred from mutant phenotype	15690042	MGI
involved in cellular response to hydroperoxide	IMP IMP: Inferred from mutant phenotype	20978343	MGI
acts upstream of or within cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	16061696	MGI
acts upstream of or within cellular response to lipoteichoic acid	IDA IDA: Inferred from direct assay	15690042	MGI
acts upstream of or within cellular response to lipoteichoic acid	IMP IMP: Inferred from mutant phenotype	15690042	MGI
involved in cellular response to low-density lipoprotein particle stimulus	IDA IDA: Inferred from direct assay	23395392	MGI
involved in cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	20978343	MGI
involved in cholesterol import	IMP IMP: Inferred from mutant phenotype	17507371	MGI
involved in cholesterol transport	IMP IMP: Inferred from mutant phenotype	12376530	MGI
acts upstream of or within defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	15690042	MGI
involved in energy homeostasis	IMP IMP: Inferred from mutant phenotype	23557700	MGI
acts upstream of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	16061696	MGI
acts upstream of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	16061696	MGI
involved in intestinal absorption	IMP IMP: Inferred from mutant phenotype	17507371	MGI
involved in intestinal cholesterol absorption	IMP IMP: Inferred from mutant phenotype	17507371	MGI
involved in lipid storage	IMP IMP: Inferred from mutant phenotype	10772654	MGI
involved in lipoprotein transport	IMP IMP: Inferred from mutant phenotype	10772654	MGI
involved in long-chain fatty acid import into cell	IMP IMP: Inferred from mutant phenotype	17507371	MGI
involved in low-density lipoprotein particle clearance	IMP IMP: Inferred from mutant phenotype	10772654	MGI
involved in low-density lipoprotein particle mediated signaling	IDA IDA: Inferred from direct assay	20978343	MGI
acts upstream of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	15690042	MGI
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	10613822	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20978343	MGI
involved in negative regulation of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	20978343	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20978343	MGI
acts upstream of or within phagocytosis, recognition	IDA IDA: Inferred from direct assay	16061696	MGI
involved in plasma lipoprotein particle clearance	IMP IMP: Inferred from mutant phenotype	12376530	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	21610069	MGI
acts upstream of or within positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	15690042	MGI
involved in positive regulation of NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	23812099	MGI
involved in positive regulation of blood coagulation	IMP IMP: Inferred from mutant phenotype	20978343	MGI
involved in positive regulation of blood microparticle formation	IMP IMP: Inferred from mutant phenotype	20978343	MGI
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	16061696	MGI
involved in positive regulation of cholesterol storage	IMP IMP: Inferred from mutant phenotype	12376530	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	25596128	MGI
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	18162488	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20037584	MGI
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	23812099	MGI
acts upstream of or within positive regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	16061696	MGI
acts upstream of or within positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	16061696	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	15690042	MGI
involved in positive regulation of macrophage derived foam cell differentiation	IMP IMP: Inferred from mutant phenotype	10772654	MGI
involved in positive regulation of nitric oxide biosynthetic process	IGI IGI: Inferred from genetic interaction	20037584	MGI
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	20978343	MGI
acts upstream of or within positive regulation of phagocytosis, engulfment	IDA IDA: Inferred from direct assay	16061696	MGI
acts upstream of or within positive regulation of phagocytosis, engulfment	IMP IMP: Inferred from mutant phenotype	16061696	MGI
involved in positive regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	20037584	MGI
involved in positive regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	20978343	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	15690042	MGI
involved in receptor internalization	IDA IDA: Inferred from direct assay	23395392	MGI
involved in regulation of action potential	IMP IMP: Inferred from mutant phenotype	29111364	MGI
involved in regulation of removal of superoxide radicals	IMP IMP: Inferred from mutant phenotype	20978343	MGI
acts upstream of or within response to bacterium	IEP IEP: Inferred from expression pattern	23012479	MGI
involved in response to fatty acid	IDA IDA: Inferred from direct assay	21610069	MGI
involved in response to fatty acid	IMP IMP: Inferred from mutant phenotype	23557700	MGI
involved in response to linoleic acid	IDA IDA: Inferred from direct assay	18162488	MGI
involved in response to lipid	IDA IDA: Inferred from direct assay	21610069	MGI
involved in response to stilbenoid	IEP IEP: Inferred from expression pattern	17086191	MGI
involved in sensory perception of taste	IDA IDA: Inferred from direct assay	18162488	MGI
involved in triglyceride transport	IMP IMP: Inferred from mutant phenotype	17507371	MGI
acts upstream of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	15690042	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	15496455	MGI
located in apical part of cell	IDA IDA: Inferred from direct assay	16276419	MGI
located in brush border membrane	IDA IDA: Inferred from direct assay	21610069	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	15690042	MGI
located in membrane	IDA IDA: Inferred from direct assay	23395392	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	15496455	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15496455	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
platelet glycoprotein 4	CD36 antigen GPIIIB PAS IV PAS-4 fatty acid translocase glycoprotein IIIb platelet glycoprotein IV

Recombinant Cd36 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72733	CD36 Protein, Mouse (HEK293, Fc)	Q08857 (G30-K439)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72355	CD36 Protein, Mouse (Biotinylated, HEK293, Avi-His)	Q08857 (G30-K439)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72894	CD36 Protein, Mouse (HEK293, His-Fc)	Q08857 (G30-K439)	≥ 85%, as determined by reducing SDS-PAGE.
HY-P72895	CD36 Protein, Mouse (HEK293, His)	Q08857 (G30-K439)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-155938	Cyano-myracrylamide	Inhibitor	98.13%	Phase 3

Bioactive MoleculesInhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991911	PLT012	Inhibitor	98.90%	Phase 1

Pre-clinical Phase

Bioactive Molecules (40)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112847A	Sulfosuccinimidyl oleate sodium	Inhibitor	99.66%	Unkown
HY-163541	SMS121	Inhibitor	99.06%	Unkown
HY-113402	Gamma-glutamylcysteine		98.53%	Unkown
HY-NP165	Advanced glycation end products		/	Unkown
HY-P3970A	KRFK TFA	Agonist	99.76%	Unkown
HY-P5322	Thrombospondin (TSP-1)-derived CD36 binding motif		99.58%	Unkown
HY-113402A	Gamma-glutamylcysteine TFA		96.68%	Unkown
HY-30216	(R)-Leucic acid		98.0%	Unkown
HY-126726	KOdiA-PC		99.00%	Unkown
HY-163649	A17	Activator	99.4%	Unkown
HY-W040255	1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine		99.9%	Unkown
HY-128671	6-Thioinosine		99.31%	Unkown
HY-NP203	High density lipoprotein (human)	Activator	98.00%	Unkown
HY-113402R	Gamma-glutamylcysteine (Standard)		98.14%	Unkown
HY-168049	ZLY06	Agonist	98.75%	Unkown
HY-RS02237	CD36 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-112847	Sulfosuccinimidyl oleate	Inhibitor	/	Unkown
HY-116003	12,13-DiHOME		99.5%	Unkown
HY-154857	1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine	Ligand	/	Unkown
HY-RS16502	Cd36 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18098	Scarb1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-108385	Ochratoxin A-D4		/	Unkown
HY-112847B	(E/Z)-Sulfosuccinimidyl oleate sodium		/	Unkown
HY-125554	KDdiA-PC	Ligand	/	Unkown
HY-168371	1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC		/	Unkown
HY-172944	GPR40 Activator 3	Activator	/	Unkown
HY-178053	AHR agonist 10		/	Unkown
HY-P10183	CD36 Peptide P (139-155), Cys conjugated	Inhibitor	/	Unkown
HY-P10184	CD36 Peptide P (93-110), Cys conjugated	Inhibitor	/	Unkown
HY-P10873	ST-CY14		/	Unkown
HY-P11033	Pep2 Peptide	Ligand	/	Unkown
HY-P11227	Compound 19A8.8	Inhibitor	/	Unkown
HY-P2696	EP 80317	Ligand	/	Unkown
HY-P2696A	EP 80317 acetate	Ligand	99.16%	Unkown
HY-P3970	KRFK	Agonist	/	Unkown
HY-W769935	5-POHSA	Modulator	/	Unkown
HY-10380	(R)-DRF053	Inhibitor	/	Unkown
HY-113402AR	Gamma-glutamylcysteine TFA (Standard)		/	Unkown
HY-113402B	Gamma-glutamylcysteine ammonium		/	Unkown
HY-RS22934	Cd36 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Bioactive MoleculesInhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990352	Anti-CD36 Antibody	Inhibitor	99.43%	Unkown
HY-P990353	Anti-CD4 Antibody (TRX1)	Inhibitor	99.28%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cd36	NCBI	NCBI:948
Canis familiaris	Cd36	NCBI	NCBI:475931
Macaca fascicularis	Cd36	NCBI	NCBI:101926577
Rattus norvegicus	Cd36	NCBI	NCBI:29184
Macaca mulatta	Cd36	NCBI	NCBI:574296