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Ccr2 - chemokine (C-C motif) receptor 2 Gene

Also Known as Ckr2; Ccr2a; Ccr2b; Ckr2a; Ckr2b; mJe-r; Cmkbr2; Cc-ckr-2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12772

About Ccr2

Chromosome 9: 123,901,987-123,913,594 forward strand.GRCm39:CM001002.3

This gene has 4 transcripts (splice variants), 151 orthologues, 25 paralogues and is associated with 103 phenotypes. Broad expression in bladder adult (RPKM 3.5), mammary gland adult (RPKM 3.2) and 17 other tissues.

Summary

Enables C-C chemokine binding activity and C-C Chemokine Receptor activity. Involved in several processes, including leukocyte migration; positive regulation of cell migration; and regulation of cytokine production. Acts upstream of or within several processes, including cellular defense response; monocyte chemotaxis; and neutrophil clearance. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Coronavirus infectious disease and age related macular degeneration. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; aggressive periodontitis; coronary artery disease (multiple); glucose metabolism disease (multiple); and uveitis (multiple). Orthologous to human CCR2 (C-C motif Chemokine Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ccr2 Products (1)

mRNA	Protein	Name
NM_009915.2	NP_034045.1	C-C chemokine receptor type 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables C-C chemokine receptor activity	IDA IDA: Inferred from direct assay	8631787	MGI
enables chemokine (C-C motif) ligand 12 binding	IPI IPI: Inferred from physical interaction	8996246	MGI
enables chemokine (C-C motif) ligand 2 binding	IPI IPI: Inferred from physical interaction	8662823	MGI
enables chemokine (C-C motif) ligand 7 binding	IPI IPI: Inferred from physical interaction	8662823	MGI
enables cytokine binding	IPI IPI: Inferred from physical interaction	8631787	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8662823	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in T-helper 17 cell chemotaxis	IDA IDA: Inferred from direct assay	18586982	MGI
acts upstream of or within cellular defense response	IMP IMP: Inferred from mutant phenotype	9366570	MGI
involved in cellular homeostasis	IDA IDA: Inferred from direct assay	18832716	MGI
acts upstream of or within hemopoiesis	IMP IMP: Inferred from mutant phenotype	9366570	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IMP IMP: Inferred from mutant phenotype	9342361	MGI
acts upstream of or within humoral immune response	IMP IMP: Inferred from mutant phenotype	10899907	MGI
acts upstream of or within immune response	IMP IMP: Inferred from mutant phenotype	10854218	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	10946288	MGI
involved in inflammatory response to wounding	IMP IMP: Inferred from mutant phenotype	24806994	MGI
acts upstream of or within leukocyte adhesion to vascular endothelial cell	IMP IMP: Inferred from mutant phenotype	9342361	MGI
involved in macrophage migration	IMP IMP: Inferred from mutant phenotype	24806994	MGI
acts upstream of or within monocyte chemotaxis	IMP IMP: Inferred from mutant phenotype	23913046	MGI
involved in monocyte extravasation	IMP IMP: Inferred from mutant phenotype	29632244	MGI
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	14566334	MGI
involved in negative regulation of eosinophil degranulation	IMP IMP: Inferred from mutant phenotype	14662900	MGI
involved in negative regulation of type 2 immune response	IMP IMP: Inferred from mutant phenotype	14662900	MGI
acts upstream of or within neutrophil clearance	IMP IMP: Inferred from mutant phenotype	9342361	MGI
involved in positive regulation of CD8-positive, alpha-beta T cell extravasation	IMP IMP: Inferred from mutant phenotype	14662900	MGI
involved in positive regulation of T cell activation	IMP IMP: Inferred from mutant phenotype	14662900	MGI
involved in positive regulation of T cell chemotaxis	IDA IDA: Inferred from direct assay	18586982	MGI
involved in positive regulation of T-helper 1 type immune response	IMP IMP: Inferred from mutant phenotype	10657654	MGI
involved in positive regulation of alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	14662900	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	24906148	MGI
involved in positive regulation of hematopoietic stem cell migration	IMP IMP: Inferred from mutant phenotype	20234092	MGI
involved in positive regulation of immune complex clearance by monocytes and macrophages	IMP IMP: Inferred from mutant phenotype	14566334	MGI
involved in positive regulation of inflammatory response	IDA IDA: Inferred from direct assay	20234092	MGI
involved in positive regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	14662900	MGI
acts upstream of or within positive regulation of leukocyte tethering or rolling	IMP IMP: Inferred from mutant phenotype	9342361	MGI
involved in positive regulation of monocyte chemotaxis	IMP IMP: Inferred from mutant phenotype	18832716	MGI
involved in positive regulation of monocyte extravasation	IMP IMP: Inferred from mutant phenotype	14566334	MGI
involved in positive regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	29993042	MGI
involved in positive regulation of thymocyte migration	IMP IMP: Inferred from mutant phenotype	29930553	MGI
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	18832716	MGI
involved in positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	14662900	MGI
involved in regulation of T cell cytokine production	IMP IMP: Inferred from mutant phenotype	28507030	MGI
involved in regulation of T cell differentiation	IMP IMP: Inferred from mutant phenotype	28507030	MGI
acts upstream of or within regulation of T cell migration	IMP IMP: Inferred from mutant phenotype	10854218	MGI
involved in regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	28507030	MGI
acts upstream of or within regulation of macrophage migration	IMP IMP: Inferred from mutant phenotype	10854218	MGI
acts upstream of or within regulation of mononuclear cell migration	IMP IMP: Inferred from mutant phenotype	10899907	MGI
involved in regulation of vascular endothelial growth factor production	IMP IMP: Inferred from mutant phenotype	14566334	MGI
acts upstream of or within sensory perception of pain	IMP IMP: Inferred from mutant phenotype	12808141	MGI
involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	29993042	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	23610400	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ccr2 Protein Structure

7tmA_CCR5_CCR2

0
100
200
300
373 a.a.

Protein Preferred Names	Protein Names
C-C chemokine receptor type 2	C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR) C-C CKR-2 CCR-2 JE/FIC receptor MCP-1 receptor MIP-1 alphaR chemoattractant protein-1 receptor chemokine (C-C) receptor 2

Recombinant Ccr2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700541	CCR2 Protein, Mouse (N-His, C-Myc)	P51683 (M1-A55)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1076	Medrysone	Activator	99.79%	Unkown
HY-117621A	PF-04634817 succinate	Antagonist	99.50%	Unkown
HY-117621	PF-04634817	Antagonist	98.87%	Unkown

Clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14882	Cenicriviroc	Antagonist	99.51%	Phase 3
HY-13245	PF-4136309	Antagonist	99.86%	Phase 2
HY-109593	BMS-813160	Antagonist	99.93%	Phase 2
HY-101713	Ilacirnon	Inhibitor	98.05%	Phase 2
HY-50669	MK-0812	Antagonist	99.89%	Phase 2
HY-135891	AZD2423	Antagonist	99.91%	Phase 2
HY-13499	JNJ-41443532	Inhibitor	99.65%	Phase 2
HY-129991	JNJ-17166864	Antagonist	/	Phase 2
HY-108432	BMS-741672	Antagonist	/	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99781	Plozalizumab	Inhibitor	99.53%	Phase 2

Pre-clinical Phase

Bioactive Molecules (40)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15418	RS 504393	Antagonist	99.72%	Unkown
HY-50674	INCB3344	Antagonist	99.81%	Unkown
HY-13406	TAK-779	Antagonist	99.89%	Unkown
HY-18611A	Abaucin	Antagonist	99.59%	Unkown
HY-18611	Abaucin hydrochloride	Antagonist	99.94%	Unkown
HY-108323	CCR2 antagonist 4	Antagonist	99.89%	Unkown
HY-14882A	Cenicriviroc Mesylate	Antagonist	99.94%	Yes
HY-103355	YM022	Antagonist	99.87%	Unkown
HY-50081	CCR2-RA-[R]	Antagonist	99.21%	Unkown
HY-15450A	INCB 3284	Antagonist	99.30%	Unkown
HY-101908	BMS CCR2 22	Antagonist	99.27%	Unkown
HY-103362	CCR2 antagonist 4 hydrochloride	Antagonist	99.91%	Unkown
HY-50669A	MK-0812 Succinate	Antagonist	99.94%	Yes
HY-101264	CCR2 antagonist 3	Antagonist	99.91%	Unkown
HY-402739	CCR2-IN-1	Inhibitor	/	Unkown
HY-110132	JNJ-27141491	Antagonist	97.01%	Unkown
HY-112792	CCR2 antagonist 1	Antagonist	95.04%	Unkown
HY-50674A	INCB3344 R-isomer		98.01%	Unkown
HY-P11553B	DOTA-ECL1i	Inhibitor	98.06%	Unkown
HY-15450	INCB 3284 dimesylate	Antagonist	≥98.0%	Unkown
HY-186265	SD-24	Antagonist	/	Unkown
HY-180571	LUF7996	Degrader	/	Unkown
HY-119658	PF-4178903	Antagonist	/	Unkown
HY-136768	YJC-10592	Antagonist	/	Unkown
HY-181681	CXCR2 antagonist 10	Antagonist	/	Unkown
HY-19009B	Propagermanium	Inhibitor	/	Unkown
HY-171681	Anti-CCL2 (Carlumab)-SPDB-DM4	Antagonist	/	Unkown
HY-171680	Anti-CCL2 (Carlumab)-SMCC-DM1	Antagonist	/	Unkown
HY-50084	CCR2-RA	Antagonist	/	Unkown
HY-P11553	ECL1i	Inhibitor	/	Unkown
HY-171685	Anti-CCL2 (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA	Antagonist	/	Unkown
HY-171684	Anti-CCL2 (Carlumab)-MC-Vc-PAB-SN38	Antagonist	/	Unkown
HY-171682	Anti-CCL2 (Carlumab)-McMMAF	Antagonist	/	Unkown
HY-180572	CCR2 ligand-1	Ligand	/	Unkown
HY-N17908	Viscumneoside V	Inhibitor	98.24%	Unkown
HY-100819	RO5234444	Antagonist	/	Unkown
HY-179607	LUF8100	Antagonist	98.64%	Unkown
HY-148100C	Emapticap pegol scramble negative control	Inhibitor	/	Unkown
HY-185299	CCR2 antagonist 6	Antagonist	/	Unkown
HY-D3598	CCR2 ligand-2	Ligand	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991745	Anti-Mouse CCR2 Antibody (C2Mab-6)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccr2	NCBI	NCBI:729230