Ccr2 - chemokine (C-C motif) receptor 2 Gene

Mus musculus

Also known as Ckr2; Ccr2a; Ccr2b; Ckr2a; Ckr2b; mJe-r; Cmkbr2; Cc-ckr-2

Gene ID: 12772 | Gene type: protein coding

About Ccr2

Chromosome 9: 123,901,987-123,913,594 forward strand.GRCm39:CM001002.3

This gene has 4 transcripts (splice variants), 151 orthologues, 25 paralogues and is associated with 103 phenotypes. Broad expression in bladder adult (RPKM 3.5), mammary gland adult (RPKM 3.2) and 17 other tissues.

Summary

Enables C-C chemokine binding activity and C-C Chemokine Receptor activity. Involved in several processes, including leukocyte migration; positive regulation of cell migration; and regulation of cytokine production. Acts upstream of or within several processes, including cellular defense response; monocyte chemotaxis; and neutrophil clearance. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Coronavirus infectious disease and age related macular degeneration. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; aggressive periodontitis; coronary artery disease (multiple); glucose metabolism disease (multiple); and uveitis (multiple). Orthologous to human CCR2 (C-C motif Chemokine Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ccr2 Products(1)

mRNA	Protein	Name
NM_009915.2	NP_034045.1	C-C chemokine receptor type 2

Ccr2 Protein Structure

7tmA_CCR5_CCR2

0
100
200
300
373 a.a.

Protein Preferred Names

Protein Names

C-C chemokine receptor type 2

C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR)	C-C CKR-2
CCR-2	JE/FIC receptor
MCP-1 receptor	MIP-1 alphaR
chemoattractant protein-1 receptor	chemokine (C-C) receptor 2

Recombinant Ccr2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700541	CCR2 Protein, Mouse (N-His, C-Myc)	P51683 (M1-A55)	≥95%

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117621	PF-04634817	Antagonist	98.87%	Unkown
HY-117621A	PF-04634817 succinate	Antagonist	≥99.0%	Unkown

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14882	Cenicriviroc	Antagonist	99.01%	Phase 3
HY-14882A	Cenicriviroc Mesylate	Antagonist	99.04%	Phase 3
HY-13245	PF-4136309	Antagonist	99.59%	Phase 2
HY-109593	BMS-813160	Antagonist	99.93%	Phase 2
HY-50669A	MK-0812 Succinate	Antagonist	99.94%	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99781	Plozalizumab	Inhibitor	95.00%	Phase 2

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15418	RS 504393	Antagonist	99.43%	Unkown
HY-50674	INCB3344	Antagonist	99.73%	Unkown
HY-18611	RS102895 hydrochloride	Antagonist	99.87%	Unkown
HY-13406	TAK-779	Antagonist	99.73%	Unkown
HY-103362	CCR2 antagonist 4 hydrochloride	Antagonist	99.86%	Unkown
HY-15450A	INCB 3284	Antagonist	99.30%	Unkown
HY-18611A	RS102895	Antagonist	99.97%	Unkown
HY-112792	CCR2 antagonist 1	Antagonist	98.00%	Unkown
HY-101908	BMS CCR2 22	Antagonist	99.87%	Unkown
HY-50081	CCR2-RA-[R]	Antagonist	99.71%	Unkown
HY-103355	YM022	Antagonist	99.93%	Unkown
HY-101713	Ilacirnon	Inhibitor	99.87%	Unkown
HY-135891	AZD2423	Antagonist	99.46%	Unkown
HY-108323	CCR2 antagonist 4	Antagonist	99.89%	Unkown
HY-13499	JNJ-41443532	Inhibitor	98.79%	Unkown
HY-50674A	INCB3344 R-isomer		97.04%	Unkown
HY-50669	MK-0812	Antagonist	99.75%	Yes
HY-15450	INCB 3284 dimesylate	Antagonist	≥98.0%	Unkown
HY-110132	JNJ-27141491	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccr2	NCBI	NCBI:729230

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